6-[[2-(dimethylamino)ethylamino]methylidene]cyclohexa-2,4-dien-1-one | 135663-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 6-[[2-(dimethylamino)ethylamino]methylidene]cyclohexa-2,4-dien-1-one
• 英文别名: N-(2'-Dimethylaminoethyl)salicylideneimine；2-[(2-dimethyl-aminoethylimino)methyl]phenol；2-[((E)-2-(dimethylamino)ethylimino)methyl]phenol
• CAS: 135663-17-1
• 化学式: C₁₁H₁₆N₂O
• 分子量: 192.261
• InChiKey: FLKVGXMTKORZSX-FMIVXFBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.37
• 重原子数：
  14.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  35.83
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  硫氰酸铵 、 nickel diacetate 、 6-[[2-(dimethylamino)ethylamino]methylidene]cyclohexa-2,4-dien-1-one 以 甲醇 为溶剂， 生成 (2-((2-(dimethylamino)ethylimino)methyl)phenolato)(thiocyanato)nickel(II)
  参考文献：
  名称：

  On the different coordination of NiII, ZnII and CdII cations in their model Schiff base complexes – Single crystal X-ray and solid state NMR studies

  摘要：

  Three model metal complexes: Ni(NCS)L, Zn-2(NCS)(2)L-2 and Cd-2(NCS)(2)L-2, consisting of the SCN- anion(s) and L = 2-[(2-dimethylaminoethylimino)-methyl]-phenolate, have been studied by X-ray diffraction and solid state NMR spectroscopy. The metal cations in these complexes have different coordination modes: Ni2+ is almost square-planar, the Zn2+ cation in Zn-2(NCS)(2)L-2 is pentacoordinated, whereas Cd2+ is penta- and hexacoordinated in [Cd-2(NCS)(2)L-2]. The different coordination of the metal cations influences the chemical shifts of the metal cations and also the nitrogen atoms. These chemical shifts can be correlated with the M-N and M-O bond lengths (M = Ni2+, Zn2+, Cd2+). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.09.020
• 作为产物：
  描述：

  水杨醛 、 N,N-二甲基乙二胺 以 乙醇 为溶剂， 生成 6-[[2-(dimethylamino)ethylamino]methylidene]cyclohexa-2,4-dien-1-one
  参考文献：
  名称：

  带有含ONN供体原子集的席夫碱配体的of（V）和rh（V）氧配合物的合成和表征。的分子结构的反式-二氯氧代[1-（8'-quinolyliminomethyl）-2- naphtholato- NN ' ø ]锝（Ⅴ）

  摘要：

  锝（六坐标络合物V）和铼（V含有MO）3+（M =锝或Re）芯从[代替MoCl合成4 ] -通过使用含有三齿席夫碱配体的配体交换反应ONN供体原子集。通式[MOCl 2 L n ] [ n = 1-4; L 1＝ 1-（8′-喹啉基亚甲基）-2-萘甲酸酯，L 2＝N-（8′-喹啉基）水杨酸酯，L 3＝ 3-甲氧基-N-（8′-喹啉基）水杨酸酯，L 4＝N-（2'-二甲基氨基乙基）水杨基亚硝酸盐]通过物理化学测量和[TcOCl 2 L 1 ]通过X射线衍射分析进行表征。最后一个络合物中的配位环境是一个扭曲的八面体，其N 2 O配体-原子组和氧-氧占据了赤道平面，并且两个氯原子在轴向位置分别是反式的。该复合物在单斜空间群P 2 1 / a中结晶，其中a = 23.262（8），b = 7.301（4），c = 11.444（5）Å，β= 98.98（5）°和Z=4。对于2 693个观察到的反射，该结构已精炼为R

  DOI：

  10.1039/dt9900002225

文献信息

• [EN] PHOTOSENSITIZER PARTICLES FOR MEDICAL IMAGING AND/OR PHOTODYNAMIC THERAPY<br/>[FR] PARTICULES DE PHOTOSENSIBILISATEUR DESTINÉES À L'IMAGERIE MÉDICALE ET/OU À LA THÉRAPIE PHOTODYNAMIQUE
  申请人：DCB USA LLC

  公开号：WO2014189796A1

  公开（公告）日：2014-11-27

  Photosensitizer particle contrast agents are suitable for medical imaging and/or photodynamic therapy. The photosensitizer particle contrast agent has a shell and a core encased by the shell. The shell consists essentially of multiple photosensitizer conjugates. Each photosensitizer conjugate consists of a photosensitizer and at least one biodegradable polymer covalently bound to the photosensitizer. The core has an echogenic contrast-enhancing material loaded therein. The photosensitizer of at least one of the multiple photosensitizer conjugates has a magnetic contrast-enhancing agent, e.g., a paramagnetic ion, chelated thereto. Methods for medical imaging use imaging compositions containing the photosensitizer particle contrast agents.

  光敏剂颗粒对比剂适用于医学成像和/或光动力疗法。光敏剂颗粒对比剂具有一个被壳包裹的壳和核心。壳主要由多个光敏剂结合物组成。每个光敏剂结合物由光敏剂和至少一个与光敏剂共价结合的可生物降解聚合物组成。核心中装载有增强超声对比的材料。多个光敏剂结合物中至少一个的光敏剂具有磁性增强对比剂，例如，螯合到其中的顺磁离子。用于医学成像的方法使用含有光敏剂颗粒对比剂的成像组合物。
• PHOTOSENSITIZER PARTICLES FOR MEDICAL IMAGING AND/OR PHOTODYNAMIC THERAPY
  申请人：DCB-USA LLC

  公开号：US20160082127A1

  公开（公告）日：2016-03-24

  Disclosed herein are photosensitizer particle contrast agents suitable for medical imaging and/or photodynamic therapy. The photosensitizer particle contrast agent has a shell and a core encased by the shell. The shell consists essentially of multiple photosensitizer conjugates. Each photosensitizer conjugate consists of a photosensitizer and at least one biodegradable polymer covalently bound to the photosensitizer. According to certain examples, the core has an echogenic contrast-enhancing material loaded therein. In alternative examples, the photosensitizer of at least one of the multiple photosensitizer conjugates has a magnetic contrast-enhancing agent, e.g., a paramagnetic ion, chelated thereto. Also disclosed herein are methods for medical imaging which use imaging compositions containing the photosensitizer particle contrast agents taught in the present disclosure.

  本文揭示了适用于医学成像和/或光动力疗法的光敏剂颗粒对比剂。该光敏剂颗粒对比剂具有一个由壳和核组成的外壳。壳主要由多种光敏剂结合物组成。每个光敏剂结合物由光敏剂和至少一种生物可降解聚合物共价结合于光敏剂上组成。根据某些示例，核内装有超声对比增强材料。在另一些示例中，至少一种多种光敏剂结合物的光敏剂具有磁性对比增强剂，例如配位到其中的顺磁离子。本文还揭示了使用本文所教授的光敏剂颗粒对比剂制备的成像组成物进行医学成像的方法。
• Comparative DNA-/BSA-binding, DNA cleavage, and cytotoxic properties of copper(II) amino/salicyl-phenolate Schiff bases (phen) complexes that induce generation of phenoxyl radicals
  作者：Anjaneyulu Mamindla、Manikandan Varadhan、Radhakrishnan Kartikeyan、Anbalagan Amuthamozhi、Mohammad Abdulkader Akbarsha、Venugopal Rajendiran

  DOI：10.1016/j.poly.2023.116534

  日期：2023.10

  A series of mixed-ligand Cu(II) complexes of the type [Cu(L1-5)(diimine)(H2O)](ClO4) (1–5) and [Cu(L6)(diimine)](ClO4) (6), where HL1-HL4 are aminophenolate Schiff base ligands viz., 2-(benzylideneamino)phenol (HL1, 1), 2-(4-fluorobenzylideneamino)phenol (HL2, 2), 2-(4-chlorobenzylideneamino)phenol (HL3, 3), and 2-(4-nitrobenzylideneamino)phenol (HL4, 4) whereas HL4 and HL5 are salicyl-phenolate Schiff

  一系列类型为 [Cu(L 1-5 )(二亚胺)(H 2 O)](ClO 4 ) ( 1 – 5 ) 和 [Cu(L 6 )(二亚胺)的混合配体 Cu(II) 配合物](ClO 4 ) ( 6 )，其中HL 1 - HL 4是氨基酚席夫碱配体，即 2-(亚苄基氨基)苯酚(HL 1 , 1)、2-(4-氟亚苄基氨基)苯酚(HL 2 , 2)、2-(4-氯亚苄基氨基)苯酚(HL 3 , 3)和2-(4-硝基亚苯亚甲基氨基)苯酚(HL 4 , 4)而HL 4和HL 5是水杨基酚盐希夫碱配体，即 2-((苯基亚氨基)甲基)苯酚(HL 5 , 5)和 ( E )-2-(((2-(二甲基氨基)乙基)亚氨基)已分离出作为主要配体的二亚胺1,10-菲咯啉 (phen) (H L 6 , 6)和作为辅助配体的二亚胺 1,10-菲咯啉 (phen)。希夫 碱 配 体 及其混合 配 体螯合物 通过光谱技术（紫外-可见光、红外、质量、1
• Sun; Kong; Yang, Polish Journal of Chemistry, 2006, vol. 80, # 9, p. 1457 - 1463
  作者：Sun、Kong、Yang、You

  DOI：——

  日期：——
• Metal Containing Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts
  申请人：Dow Corning Corporation

  公开号：US20150337190A1

  公开（公告）日：2015-11-26

  A composition is capable of curing via condensation reaction. The composition uses a new condensation reaction catalyst. The new condensation reaction catalyst is used to replace conventional tin catalysts. The composition can react to form a gum, gel, rubber, or resin.