4-methoxy-5,6,7,8-tetrahydro-[1]naphthylamine | 117461-79-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 4-methoxy-5,6,7,8-tetrahydro-[1]naphthylamine
• 英文别名: 8-Amino-5-methoxy-1.2.3.4-tetrahydro-naphthalin；4-Methoxy-5,6,7,8-tetrahydro-1-naphthalenylamine；4-methoxy-5,6,7,8-tetrahydronaphthalen-1-amine
• CAS: 117461-79-7
• 化学式: C₁₁H₁₅NO
• 分子量: 177.246
• InChiKey: QGYLGAVUSZYRMV-UHFFFAOYSA-N

物化性质

• 熔点：
  61 °C
• 沸点：
  340.3±42.0 °C(Predicted)
• 密度：
  1.090±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methoxy-5,6,7,8-tetrahydro-[1]naphthylamine 在 盐酸 、 N,N-二乙基苯胺 作用下， 以 甲醇 为溶剂， 反应 336.0h， 生成 1,2,3,4,7,8,9,10-octahydro-3-hydroxy-6-methoxybenzquinoline
  参考文献：
  名称：

  Malesani, Giorgio; Ferlin, Maria Grazia; Chiarelotto, Gianfranco, Gazzetta Chimica Italiana, 1988, vol. 118, # 1, p. 31 - 34

  摘要：

  DOI：
• 作为产物：
  描述：

  4-amino-5,6,7,8-tetrahydronaphthalen-1-ol 在 盐酸 、 乙醇 、 alkaline solution 作用下， 生成 4-methoxy-5,6,7,8-tetrahydro-[1]naphthylamine
  参考文献：
  名称：

  来自4-甲氧基-1-萘胺的药学上感兴趣的化合物。

  摘要：

  DOI：

  10.1021/jo01175a005

文献信息

• 一类苯磺酰肼化合物、制备方法及其用途
  申请人：佛山市赛维斯医药科技有限公司

  公开号：CN104592066B

  公开（公告）日：2016-04-06

  本发明涉及与2型糖尿病相关的药物领域。具体而言，本发明涉及一类含苯磺酰肼结构的GPR119激动剂、其制备方法、以及在制备2型糖尿病药物中的应用。其中，R选自C1-C3的烷基。
• Oxidation dyeing process using a composition comprising a monoaminobenzene and a metal catalyst
  申请人：L'OREAL

  公开号：US10251827B2

  公开（公告）日：2019-04-09

  The invention relates to a process for dyeing keratin fibers, comprising the use of one or more metal catalysts and of a composition (A) comprising: —one or more oxidizing agents, and —at least one monoaminobenzene of formula (I), or an addition salt or solvate thereof in which the radicals R1 to R5 represent, independently of each other: a hydrogen atom; a halogen atom, a C1-C6 alkyl radical, a C1-C6 alkoxy radical, a carboxylic radical (—COOH), a sulfonic radical (—S03 H); two of the adjacent radicals R1 to R5 possibly forming, with the carbon atoms that bear them, a saturated or unsaturated 5- to 7-membered ring, optionally comprising from 1 to 2 heteroatoms, preferably oxygen, the said ring being optionally fused with a saturated or unsaturated 5- to 6-membered ring; on condition that at least one of the radicals R1 to R5 represents an optionally substituted alkoxy radical and preferably at least one of the other radicals R1 to R5 is a hydrogen atom.

  本发明涉及一种角蛋白纤维染色工艺，包括使用一种或多种金属催化剂和一种组合物（A），组合物（A）包括： -一种或多种氧化剂，和 -至少一种式（I）的单胺苯，或其加成盐或溶液，其中自由基 R1 至 R5 各自代表：氢原子、卤素原子、C1-C6 烷基、C1-C6 烷氧基、羧基 (-COOH)、磺酸基 (-S03 H)；R1 至 R5 中相邻的两个基团可与含有它们的碳原子形成饱和或不饱和的 5 至 7 元环，可选择包含 1 至 2 个杂原子，最好是氧，所述环可选择与饱和或不饱和的 5 至 6 元环融合；条件是 R1 至 R5 自由基中至少有一个代表任选取代的烷氧基，且 R1 至 R5 自由基中至少有一个是氢原子。
• MALESANI, GIORGIO;FERLIN, MARIA GRAZIA;CHIARELOTTO, GIANFRANCO;DALLE, CAR+, GAZZ. CHIM. ITAL., 118,(1988) N 1, 31-34
  作者：MALESANI, GIORGIO、FERLIN, MARIA GRAZIA、CHIARELOTTO, GIANFRANCO、DALLE, CAR+

  DOI：——

  日期：——
• OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING A MONOAMINOBENZENE AND A METAL CATALYST
  申请人：L'OREAL

  公开号：US20160128922A1

  公开（公告）日：2016-05-12

  The invention relates to a process for dyeing keratin fibres, comprising the use of one or more metal catalysts and of a composition (A) comprising: —one or more oxidizing agents, and —at least one monoaminobenzene of formula (I), or an addition salt or solvate thereof in which the radicals R1 to R5 represent, independently of each other: a hydrogen atom; a halogen atom, a C1-C6 alkyl radical, a C1-C6 alkoxy radical, a carboxylic radical (—COOH), a sulfonic radical (—SO3 H); two of the adjacent radicals R1 to R5 possibly forming, with the carbon atoms that bear them, a saturated or unsaturated 5- to 7-membered ring, optionally comprising from 1 to 2 heteroatoms, preferably oxygen, the said ring being optionally fused with a saturated or unsaturated 5- to 6-membered ring; on condition that at least one of the radicals R1 to R5 represents an optionally substituted alkoxy radical and preferably at least one of the other radicals R1 to R5 is a hydrogen atom.
• [EN] OXIDATION DYEING PROCESS USING A COMPOSITION COMPRISING A MONOAMINOBENZENE AND A METAL CATALYST<br/>[FR] PROCÉDÉ DE COLORATION PAR OXYDATION À L'AIDE D'UNE COMPOSITION COMPRENANT UN MONOAMINOBENZÈNE ET UN CATALYSEUR MÉTALLIQUE
  申请人：OREAL

  公开号：WO2014202787A1

  公开（公告）日：2014-12-24

  The invention relates to a process for dyeing keratin fibres, comprising the use of one or more metal catalysts and o f a composition (A) comprising : - one or more oxidizing agents, and - at least one monoaminobenzene of formula (I), or an addition salt or solvate thereof in which the radicals R1 to R5 represent, independently of each other: a hydrogen atom; a halogen atom, a C1-C6 alkyl radical, a C1-C6 alkoxy radical, a carboxylic radical (-COOH), a sulfonic radical (-S03 H); two of the adjacent radicals R1 to R5 possibly forming, with the carbon atoms that bear them, a saturated or unsaturated 5- to 7-membered ring, optionally comprising from 1 to 2 heteroatoms, preferably oxygen, the said ring being optionally fused with a saturated or unsaturated 5- to 6- membered ring; on condition that at least one of the radicals R1 to R5 represents an optionally substituted alkoxy radical and preferably at least one of the other radicals R1 to R5 is a hydrogen atom.