fluoren-9-one O-acetyloxime | 21160-07-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: fluoren-9-one O-acetyloxime
• 英文别名: fluoren-9-one acetyloxime；fluoren-9-on-(O-acetyl oxime )；Fluoren-9-on-(O-acetyl-oxim)；Fluorenonoximacetat；(Fluoren-9-ylideneamino) acetate
• CAS: 21160-07-6
• 化学式: C₁₅H₁₁NO₂
• 分子量: 237.258
• InChiKey: DQOITARARXXHJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  pentacarbonyl(1-ethoxy-3-phenylpropyn-1-ylidene)tungsten 、 fluoren-9-one O-acetyloxime 以 甲苯 为溶剂， 反应 18.0h， 以31%的产率得到5'-ethoxy-3'-phenylspiro[fluorene-9,2'-pyrrole]
  参考文献：
  名称：

  Addition of Oxime Derivatives to Alkynyl Fischer Carbene Complexes

  摘要：

  The addition of oxime derivatives to alkynyl Fischer carbene complexes has been explored through a combined experimental and computational approach. Up to four different heterocycles with diverse regiochemistry and ring size were found, depending on the starting ketone. The reaction mechanism was studied by DFT methods.

  DOI：

  10.1021/om300570q
• 作为产物：
  描述：

  9-芴酮肟 、 乙酸酐 生成 fluoren-9-one O-acetyloxime
  参考文献：
  名称：

  Wegerhoff, Justus Liebigs Annalen der Chemie, 1889, vol. 252, p. 36

  摘要：

  DOI：

文献信息

• Camptothecin derivatives as chemoradiosensitizing agents
  申请人：Yang Li-Xi

  公开号：US20070093432A1

  公开（公告）日：2007-04-26

  Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.

  基于紫杉醇的化合物通过将该化合物与放射疗法结合在一起向哺乳动物体内施用，对治疗肿瘤具有益处，即使用放射性物质或来自主体外部源的辐射治疗肿瘤。通过在紫杉醇结构周围定位至少一个电子亲和基团来改性基于紫杉醇的化合物，以增强它们与放射疗法结合的价值。还披露了新的基于紫杉醇的化合物，可通过单独或与放射疗法结合使用这些新化合物来治疗癌症。
• CAMPTOTHECIN DERIVATIVES AS CHEMORADIOSENSITIZING AGENTS
  申请人：YANG Li-Xi

  公开号：US20080318873A1

  公开（公告）日：2008-12-25

  Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.

  基于喜树碱的化合物可用于治疗哺乳动物主体中的肿瘤，通过将该化合物与放射治疗结合给予主体治疗，即使用放射性物质或来自主体外部的辐射治疗肿瘤。将至少一个电子亲和基团定位于喜树碱结构周围，以增强其与放射治疗结合的价值而改性基于喜树碱的化合物。揭示了新的基于喜树碱的化合物，可通过单独或与放射治疗结合给予治疗，用于治疗癌症。
• The Reaction of Ketoximes with Hypervalent Iodine Reagents: Beckmann Rearrangement and Hydrolysis to Ketones
  作者：Tomohiro Maegawa、Yasuyoshi Miki、Ryohei Oishi、Ayumi Maekawa、Kazutoshi Segi、Hiromi Hamamoto、Akira Nakamura

  DOI：10.1055/a-1835-2188

  日期：2022.9

  We investigated the reaction of ketoximes with hypervalent iodine reagents. A combination of PhI(OAc)2 and BF3·Et2O promoted the Beckmann rearrangement of ketoximes, thus yielding the corresponding amides. From a detailed investigation of the reaction, we determined that the Beckmann rearrangement is preceded by acetylation of the hydroxy group of the ketoxime in situ, accelerating the Beckmann rearrangement

  我们研究了酮肟与高价碘试剂的反应。PhI(OAc) 2和BF 3 ·Et 2 O的组合促进了酮肟的贝克曼重排，从而产生了相应的酰胺。通过对反应的详细研究，我们确定贝克曼重排之前是酮肟的羟基原位乙酰化，加速了贝克曼重排。我们证实乙酰化酮肟与BF 3 ·Et 2 O 发生贝克曼重排。酮肟与Koser 试剂[PhI(OH)OTs] 在四氢呋喃存在下发生水解，在室温下以高产率提供相应的酮温度。
• Kawase,M.; Kikugawa,Y., Journal of the Chemical Society. Perkin transactions I, 1979, p. 643 - 645
  作者：Kawase,M.、Kikugawa,Y.

  DOI：——

  日期：——
• N-Substituted Imines by the Copper-Catalyzed <i>N</i>-Imination of Boronic Acids and Organostannanes with <i>O</i>-Acyl Ketoximes
  作者：Songbai Liu、Ying Yu、Lanny S. Liebeskind

  DOI：10.1021/ol070561w

  日期：2007.5.1

  Catalytic quantities of copper(I) or copper(II) sources catalyze the N-imination of boronic acids and organostannanes through reaction with oxime O-carboxylates under nonbasic conditions. This method tolerates various functional groups and takes place efficiently using aryl, heteroaryl, and alkenyl boronic acids and stannanes.