2-Morpholino-4-hydrazino-chinazolin | 93086-46-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-Morpholino-4-hydrazino-chinazolin
• 英文别名: 4-hydrazino-2-morpholin-4-yl-quinazoline；(2-Morpholin-4-ylquinazolin-4-yl)hydrazine
• CAS: 93086-46-5
• 化学式: C₁₂H₁₅N₅O
• 分子量: 245.284
• InChiKey: JDTPWJYBMSUVCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  76.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-Morpholino-4-hydrazino-chinazolin 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 1.0h， 以47%的产率得到Tetrazolo-4-morpholino-chinazolin
  参考文献：
  名称：

  Amidinoyl isothiocyanates in the synthesis of condensed heterocycles: Tetrazolo-azidoazomethine tautomerism in substituted tetrazolo[1,5-c]quinazolines

  摘要：

  Isomerization of available amidinoyl isothiocyanates has been elaborated into a viable synthetic approach to sec. amine substituted tetrazolo[1,5-c]quinazolines. The method involves isomerization to quinazoline-4-thiones, their hydrazinolysis, followed by a nitrosation to give the title tetrazoloquinazolines. Infrared spectra of both solid samples and their solutions were used to assess the stability of the tetrazole ring.

  DOI：

  10.1007/bf00815923
• 作为产物：
  描述：

  2-morpholin-4-yl-3H-quinazoline-4-thione 在 一水合肼 作用下， 以 乙醇 为溶剂， 以65%的产率得到2-Morpholino-4-hydrazino-chinazolin
  参考文献：
  名称：

  Stankovsky, Stefan; Sokyrova, Maria, Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 8, p. 1795 - 1799

  摘要：

  DOI：

文献信息

• Postovskii,I.Ya.; Goncharova,I.N., Journal of general chemistry of the USSR, 1963, vol. 33, p. 2274 - 2280
  作者：Postovskii,I.Ya.、Goncharova,I.N.

  DOI：——

  日期：——
• STAKOVSKY, S.;SOKYROVA, M., COLLECT. CZECH. CHEM. COMMUN., 1984, 49, N 8, 1795-1799
  作者：STAKOVSKY, S.、SOKYROVA, M.

  DOI：——

  日期：——
• Stankovsky, Stefan; Sokyrova, Maria, Collection of Czechoslovak Chemical Communications, 1984, vol. 49, # 8, p. 1795 - 1799
  作者：Stankovsky, Stefan、Sokyrova, Maria

  DOI：——

  日期：——
• Amidinoyl isothiocyanates in the synthesis of condensed heterocycles: Tetrazolo-azidoazomethine tautomerism in substituted tetrazolo[1,5-c]quinazolines
  作者：Štefan Stankovsky、Katarina Špirkova

  DOI：10.1007/bf00815923

  日期：1991.10

  Isomerization of available amidinoyl isothiocyanates has been elaborated into a viable synthetic approach to sec. amine substituted tetrazolo[1,5-c]quinazolines. The method involves isomerization to quinazoline-4-thiones, their hydrazinolysis, followed by a nitrosation to give the title tetrazoloquinazolines. Infrared spectra of both solid samples and their solutions were used to assess the stability of the tetrazole ring.