2,3,5,7-四羟基-1,4-萘二酮 | 604-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 2,3,5,7-四羟基-1,4-萘二酮
• 英文名称: spinochrome B
• 英文别名: 2,3,5,7-Tetrahydroxy-[1,4]naphthochinon；2,3,5,7-Tetrahydroxy-1,4-naphthalenedione；2,3,5,7-tetrahydroxynaphthalene-1,4-dione
• CAS: 604-46-6
• 化学式: C₁₀H₆O₆
• 分子量: 222.154
• InChiKey: RWRKDUHFUYRCIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,3,5,7-四羟基-1,4-萘二酮 在 双氧水 、 potassium carbonate 、 溶剂黄146 、 丙酮 作用下， 生成 3,5-二甲氧基邻苯二甲酸
  参考文献：
  名称：

  Okajima, Scientific Papers of the Institute of Physical and Chemical Research (Japan), 1959, vol. 53, p. 356,372

  摘要：

  DOI：
• 作为产物：
  描述：

  3,5-Dimethoxy-2,7-dioxo-1a.2.7.7a-tetrahydro-oxirenonaphthalin 在 sodium hydroxide 、 三氯化铝 、 硫酸 、 sodium chloride 作用下， 生成 2,3,5,7-四羟基-1,4-萘二酮
  参考文献：
  名称：

  204.自然产生的醌。第五部分Spinochromes E和N

  摘要：

  DOI：

  10.1039/jr9610001008

文献信息

• Synthesis of juglone derivatives
  作者：H. Singh、T.L. Folk、P.J. Scheuer

  DOI：10.1016/0040-4020(69)80052-9

  日期：——

  A number of hydroxyjuglones were prepared by the Thiele-Winter reaction onjuglone derivatives and by hydroxylation with ethanol-hydrochloric acid: 2-hydroxy, 3-hydroxy, 2,7-dihydroxy, 3,7-di-hydroxy, 6-acetyl-2-hydroxy, and 6-acetyl-3-hydroxyjuglone. By reductive acetylation of hydroxyjuglones, followed by Fries rearrangement and oxidative hydrolysis several acetyljuglones, and from them ethyljuglones

  通过Thiele-Winter反应onjuglone衍生物并用乙醇-盐酸进行羟基化反应，制得了许多羟基juglones：2-羟基，3-羟基，2,7-二羟基，3,7-二羟基，6-乙酰基-2 -羟基和6-乙酰基-3-羟基juglone。通过对羟基juglones进行还原性乙酰化，然后进行弗里斯重排和氧化水解，从而合成了几个乙酰juglones，并通过硼氢化钠还原从中合成了乙基juglones：3-乙酰基-2-羟基，6-乙酰基-2,3-二羟基，6-乙酰基- 2,7-二羟基和6-乙酰基-2,3,7-三羟基胡胶。先前已从海胆棘中分离出几种新合成的化合物。
• Method of preventing polymer-scale formation
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP0320227A2

  公开（公告）日：1989-06-14

  A method of preventing polymer scales from sticking in a polymerization vessel during the polymerization of a monomer having an ethylenically double bond, wherein said polymerization is carried out in a polymerization vessel of which the inner wall and other parts with which said monomer comes into contact during polymerization are previously first coated with (a) a coating solution comprising a cationic dye and the resulting coating is then coated with (b) a coating solution comprising at least one component selected from the group consisting of anionic polymeric compounds, amphoteric polymeric compounds and hydroxyl group-containing organic compounds. Polymer scale formation can be effectively prevented.

  一种在具有乙烯双键的单体聚合过程中防止聚合物鳞片粘附在聚合容器中的方法，其中所述聚合在聚合容器中进行，聚合容器的内壁和在聚合过程中与所述单体接触的其他部分之前先涂有(a)由阳离子染料组成的涂层溶液，然后在所得涂层上涂有(b)由至少一种从阴离子聚合物化合物、两性聚合物化合物和含羟基有机化合物组成的组中选出的组分组成的涂层溶液。可有效防止聚合物结垢。
• PERITONEAL THERAPEUTIC FLUID
  申请人：Opterion Health AG

  公开号：EP3120842A1

  公开（公告）日：2017-01-25

  Peritoneal therapeutic fluid comprising one or more of a biocompatibility enhancing agent (BCA) that is selected from the group consisting of a polyphenolic compound, a metabolite of a polyphenolic compound which is obtained by metabolization in the human or animal body, a salt or a glycoside of a polyphenolic compound.

  含有一种或多种生物相容性增强剂（BCA）的腹膜治疗液，这种生物相容性增强剂选自多酚类化合物、多酚类化合物在人或动物体内代谢产生的代谢产物、多酚类化合物的盐或糖苷组成的组。
• AQUEOUS SOLUTION COMPRISING A POLYPHENOL
  申请人：Opterion Health AG

  公开号：EP3120838A1

  公开（公告）日：2017-01-25

  Aqueous solution, comprising, in dissolved state, - at least one polyphenolic compound (e. g. resveratrol or piceid) - at least one saccharide (e. g. glucose or icodextrin), and method for increasing the solubility of a polyphenolic compound in water

  水溶液，以溶解状态包含 - 至少一种多酚类化合物（如白藜芦醇或 piceid） - 至少一种糖类（如葡萄糖或冰糖糊精）、 以及提高多酚类化合物在水中溶解度的方法
• Formulation and process for modulating wound healing
  申请人：BioMendics, LLC

  公开号：US10426742B2

  公开（公告）日：2019-10-01

  Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I): wherein: L represents a linker selected from —C≡C—, (a tolan), —CH═CH— (a stilbene, preferably trans); or —CRa═CRb— a stilbene derivative; where Ra and Rb are independently H or phenyl optionally substituted with —(R3)p or —(R4)q; R1 to R4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3′, 4, 4′, and/or 5, 5′; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≥1. Each R1 to R2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.

  本发明公开了通过调节自噬促进伤口愈合的方法和化合物。用于调节自噬的制剂包括选自具有一般结构 (I) 的化合物的第一调节化合物 (FAM)： 其中L 代表选自-C≡C-（甲苯）、-CH═CH-（二苯乙烯，最好是反式）或-CRa═CRb-二苯乙烯衍生物的连接体；其中 Ra 和 Rb 独立地是 H 或任选被-(R3)p 或-(R4)q 取代的苯基； R1至R4是独立的取代基，位于苯基环的任何可用位置，优选位于3，3′、4，4′和/或5，5′；m、n、p和q分别独立地为0、1、2或3，代表环的取代基数目，但m或n中至少有一个必须≥1。每个 R1 至 R2 独立地选自本文所述的取代基，包括但不限于羟基、烷氧基、卤代、卤代甲基和苷。制剂还可包括本文所述的辅助自噬调节化合物（AAM）。制剂可包括由化合物本身或以其它方式形成的水凝胶，并可包括盐和/或复合物。