2,3-bis(bromomethyl)-6-hydroxyquinoxaline | 33106-90-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2,3-bis(bromomethyl)-6-hydroxyquinoxaline
• 英文别名: 2,3-Bis(bromomethyl)quinoxalin-6-ol
• CAS: 33106-90-0
• 化学式: C₁₀H₈Br₂N₂O
• 分子量: 331.994
• InChiKey: AGCDOQKDJYTUID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-甲氧基邻苯二胺 在 三溴化硼 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 122.0h， 生成 2,3-bis(bromomethyl)-6-hydroxyquinoxaline
  参考文献：
  名称：

  Synthesis and antimicrobial activity of 2,3-bis(bromomethyl)quinoxaline derivatives

  摘要：

  We synthesized 12 derivatives of 2,3-bis(bromomethyl) quinoxaline with substituents at the 6-and/or 7-positions, and evaluated their activities against bacteria and fungi. Of the 12 compounds, nine (1a-h, 1j, and 1k) showed antibacterial activity. The derivative 1g, which bears a trifluoromethyl group at the 6-position, showed the highest activity against Gram-positive bacteria, while 1c, which has a fluoro-group at the 6-position, showed the widest antifungal activity spectrum. However, only the derivative with an ethyl ester substitution, 1k showed activity against Gram-negative bacteria. (C) 2012 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2011.12.002