22-phenyl-23,24-dinor-chol-5-ene-3β,22β_F-diol | 103330-64-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 22-phenyl-23,24-dinor-chol-5-ene-3β,22β_F-diol
• 英文别名: 22-Phenyl-23,24-dinor-chol-5-en-3β,22β_F-diol；3β-Hydroxy-10.13-dimethyl-17β-((1S:2S)-2-hydroxy-1-methyl-2-phenyl-aethyl)-gonen-(5)；(20S:21S)-20-Methyl-21-phenyl-pregnen-(5)-diol-(3β.21)；(10R)-3c-Hydroxy-10r.13c-dimethyl-17c-((1S:2S)-2-hydroxy-1-methyl-2-phenyl-aethyl)-(8cH.9tH.14tH)-Δ⁵-tetradecahydro-1H-cyclopenta[a]phenanthren；(21S)-20β_F-Methyl-21-phenyl-pregnen-(5)-diol-(3β.21)；(3S,8S,9S,10R,13S,14S,17R)-17-[(1S,2S)-1-hydroxy-1-phenylpropan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 103330-64-9
• 化学式: C₂₈H₄₀O₂
• 分子量: 408.624
• InChiKey: OZKBXSYZYPYDKY-AERJHYKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  22-phenyl-23,24-dinor-chol-5-ene-3β,22β_F-diol 在 溴 、 溶剂黄146 作用下， 生成 (10R)-3-oxo-10r.13c-dimethyl-17c-((S)-2-oxo-1-methyl-2-phenyl-ethyl)-(8cH.9tH.14tH)-Δ⁴-tetradecahydro-1H-cyclopenta[a]phenanthrene
  参考文献：
  名称：

  Changing Water and Sewer Finance:Distributional Impacts and Effects on the Viability of Affordable Housing

  摘要：

  Usage-based charges finance an increasing share of water and sewer costs in the U.S. The shift has been especially sharp in New York City, where residential users traditionally did not pay usage-based charges. In this article, we examine the impact that a transition to universal metered billing would have on multifamily housing. We find that universal metering would result in large increases in water and sewer bills for many multifamily buildings in low-income neighborhoods. Comparing the predicted increases with the net operating income of landlords in low-income neighborhoods indicates that universal metering might pose a threat to the viability of much affordable housing.

  DOI：

  10.1080/01944360108976250
• 作为产物：
  描述：

  phenylmagnesium bromide 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 、 甲苯 作用下， 生成 22-phenyl-23,24-dinor-chol-5-ene-3β,22β_F-diol
  参考文献：
  名称：

  bisnor-5-cholenaldehyde的衍生物。

  摘要：

  DOI：

  10.1021/ja01200a035

文献信息

• The Dehydration of 22-Phenyl-3-methoxy-22-hydroxy-bisnor-5-cholene
  作者：F. W. Heyl、M. E. Herr、A. P. Centolella

  DOI：10.1021/ja01169a063

  日期：1949.1
• 3-substituted-22-monophenyl-bisnor-5, 20-choladienes and production of pregnenolone therefrom
  申请人：UPJOHN CO

  公开号：US02576937A1

  公开（公告）日：1951-12-04
• Cole; Julian, Journal of the American Chemical Society, 1945, vol. 67, p. 1369,1372
  作者：Cole、Julian

  DOI：——

  日期：——
• Steroid Studies. X.¹ Studies on the Configuration of 22-Hydroxycholesterol from Narthecium ossifragum Huds
  作者：Kyosuke Tsuda、Ryoichi Hayatsu

  DOI：10.1021/ja01531a034

  日期：1959.11
• Dehydration of steroid side-chain secondary alcohols
  申请人：UPJOHN CO

  公开号：US02589305A1

  公开（公告）日：1952-03-18