2-phenylbenzofuran-4-yl benzoate | 24534-41-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 2-phenylbenzofuran-4-yl benzoate
• 英文别名: 4-benzoyloxy-2-phenyl-benzofuran；2-phenyl-4-benzoyloxy benzofuran；(2-Phenylbenzofuran-4-yl) benzoate；(2-phenyl-1-benzofuran-4-yl) benzoate
• CAS: 24534-41-6
• 化学式: C₂₁H₁₄O₃
• 分子量: 314.34
• InChiKey: QTXSWNSDRBDDEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-碘苯-1,3-二醇 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 生成 2-phenylbenzofuran-4-yl benzoate
  参考文献：
  名称：

  Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth

  摘要：

  A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falciparum and Tiypanosoma brucei parasites. Some of them exhibited good inhibitory activity on T. brucei proliferation. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.07.002

文献信息

• Reduction par les sels chromeux de bromures benzyliques ortho-o-acyles avec transposition du groupement acyle
  作者：B. Ledoussal、A. Gorgues、A. Le Coq

  DOI：10.1016/s0040-4020(01)87790-5

  日期：——

  σ-bonded organochromium (III) complexes resulting from the reduction of-O-acyl benzylic bromides with CrCl2., undergo an 1,5-transposition of the ester acyl functional group which allows, through selected experimental conditions either a selective access to the unmasked -hydroxybenl ketones or a new preparation of the 2-substituted benzo¦b¦furans . The scope and limitations of the method are presented

  由-O-酰基苄基溴化物经CrCl 2还原而形成的σ键合有机铬（III）配合物经历了酯酰基官能团的1,5-转移，这允许通过选择的实验条件或者选择性地获得非掩蔽的羟基苯甲酮或2-取代的苯并γ-b呋喃的新制备方法。介绍了该方法的范围和局限性。
• Chromium(II) salt mediated reductive transposition of an ester acyl group in ortho-O-acyl benzylic bromides: a ready access to unmasked ortho-hydroxybenzyl ketones and a new route to benzo[b]furans
  作者：Beno�t Ledoussal、Alain Gorgues、Andr� Le Coq

  DOI：10.1039/c39860000171

  日期：——

  The mono-σ-bonded organochromium(III) complexes (A) derived from (1) rearrange internally into (B) through an acyl ester group transposition, selected experimental conditions allowing either a good access to the unmasked ortho-hydroxybenzyl ketones (2) or a new route to the 2-substituted benzo[b]furans (3).

  衍生自（1）的单σ键合有机铬（III）配合物通过酰基酯基转移在内部重新排列为（B），选择的实验条件使得可以很好地接触未掩盖的邻羟基苄基酮（2）或新的途径取代2-取代的苯并[ b ]呋喃（3）。
• Process for the synthesis of derivatives of the benzofuran, chromene and
  申请人：Agence Nationale de Valorisation de la Recherche

  公开号：US04230624A1

  公开（公告）日：1980-10-28

  The invention relates to a process for the production of therapeutic compounds of the benzofuran, chromene and isochromene type of the general formula; ##STR1## in which formula, ##STR2## R.sub.1 and R.sub.3 =H, lower alkyl, aralkyl or cycloalkyl R.sub.2 =H or an organic radical and when D= ##STR3## R.sub.1 and R.sub.3 may represent an organic radical. The process comprising the cyclization in the liquid phase and in the presence of a base a compound of the formula; ##STR4## in which formula; R'=an alkyl, aryl or aralkyl radical and X.sup.- =an anion.

  该发明涉及一种用于生产苯并呋喃、色甲醛和异色甲醇类治疗化合物的过程，其通式为; 在该式中，R.sub.1 和 R.sub.3 =H、较低烷基、芳基烷基或环烷基，R.sub.2 =H 或有机基，当 D= 时，R.sub.1 和 R.sub.3 可表示有机基。该过程包括在液相中和在碱存在下进行环化的化合物； 在该式中； R'=烷基、芳基或芳基烷基基团，X.sup.- =阴离子。
• LEDOUSSAL, B.;GORGUES, A.;LE, COQ, A., J. CHEM. SOC. CHEM. COMMUN., 1986, N 2, 171-172
  作者：LEDOUSSAL, B.、GORGUES, A.、LE, COQ, A.

  DOI：——

  日期：——
• LEDOUSSAL, B.;GORGUES, A.;LE, COQ A., TETRAHEDRON, 43,(1987) N 24, 5841-5852
  作者：LEDOUSSAL, B.、GORGUES, A.、LE, COQ A.

  DOI：——

  日期：——