Bis-(4-cyanamidophenyl)-methan | 30070-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bis-(4-cyanamidophenyl)-methan
• 英文别名: 4,4'-methylene-bis-(phenylcyanamide)；Cyanamide, (methylenedi-4,1-phenylene)bis-；[4-[[4-(cyanoamino)phenyl]methyl]phenyl]cyanamide
• CAS: 30070-39-4
• 化学式: C₁₅H₁₂N₄
• 分子量: 248.287
• InChiKey: CDUBEKURLDHASH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  71.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Bis-(4-cyanamidophenyl)-methan 在 盐酸 、 盐酸羟胺 、 potassium carbonate 作用下， 以 乙醚 、 乙醇 为溶剂， 生成 2-[4-[[4-[[Amino-(hydroxyamino)methylidene]amino]phenyl]methyl]phenyl]-1-hydroxyguanidine;hydrochloride
  参考文献：
  名称：

  Aromatic Bis-N-hydroxyguanidinium Derivatives: Synthesis, Biophysical, and Biochemical Evaluations

  摘要：

  In this paper we report the synthesis of a new family of hydroxyguanidinium aromatic derivatives (4a-g) as potential minor groove binders and cytotoxic agents. Their DNA affinity was evaluated by thermal denaturation experiments using salmon sperm DNA. The antiproliferative effects of derivatives 4a, 4d, and 4f were evaluated in human promyelocytic HL-60, breast carcinoma MCF-7, and neuroblastoma Kelly cell lines using the AlamarBlue viability assay, and IC50 values were obtained. All three compounds were active in the HL-60 cell line. In particular, 4b exhibits antiproliferative effects in all three cell lines while 4d reduced HL-60 and Kelly viability. Both 4b and 4d produced considerable antiproliferative activity in the Kelly cell line. Derivative 4d was chosen for further cell cycle and apoptosis studies using flow cytometric analysis of cellular DNA content.

  DOI：

  10.1021/jm301358s
• 作为产物：
  描述：

  4,4'-二氨基二苯甲烷 生成 Bis-(4-cyanamidophenyl)-methan
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• N-cyanocarboxylic acid amides, processes for their preparation and their
  申请人：Ciba-Geigy Corporation

  公开号：US04618712A1

  公开（公告）日：1986-10-21

  N-Cyanocarboxlic acid amide derivatives which contain two or three ##STR1## groupings in the molecule are obtained by reacting 1 mol of a dicyanodiamine with 2 mols of a carboxylic acid anhydride or 1 mol of a dicyandiamine salt with 2 mols of a carboxylic acid halide or 1 mol of a dihalogeno compound with 2 mols of an N-cyanocarboxylic acid amide salt, or by reacting 1 mol of a carboxylic acid dichloride or trichloride with 2 or, respectively, 3 mols of a cyanamide or 1 mol of a carboxylic acid dicyandiamide or tricyantriamide salt with 2 or 3 mols of an alkylating agent. The N-cyanocarboxylic acid amide derivatives according to the invention are useful hardeners for epoxide resins.

  通过将1摩尔的二氰二胺与2摩尔的羧酸酐或1摩尔的二氰二胺盐与2摩尔的羧酸卤化物或1摩尔的二卤化合物与2摩尔的N-氰基羧酸酰胺盐反应，或者通过将1摩尔的羧酸二氯化物或三氯化物与2或3摩尔的氰胺或1摩尔的羧酸二氰二胺或三氰三胺盐与2或3摩尔的烷基化剂反应，可以获得分子中含有两个或三个##STR1##基团的N-氰基羧酸酰胺衍生物。根据本发明的N-氰基羧酸酰胺衍生物是环氧树脂的有用硬化剂。
• Epoxy resin compositions containing N-cyanocarboxylic acid amides as
  申请人：Ciba-Geigy Corporation

  公开号：US04721770A1

  公开（公告）日：1988-01-26

  N-Cyanocarboxylic acid amide derivatives which contain two or three ##STR1## groupings in the molecule are useful as hardeners for epoxide resins.

  分子中含有两个或三个##STR1##基团的N-氰基羧酸酰胺衍生物可作为环氧树脂的硬化剂。
• Thermosetting resin composition, prepolymer thereof and cured article thereof
  申请人：Hitachi, Ltd.

  公开号：EP0078039A1

  公开（公告）日：1983-05-04

  A thermosetting resin composition comprising (A) at least one dicyanamide compound and (B) at least one polyvalent imide having one or more unsaturated bonds and, if necessary (C) at least one polymerizable compound of epoxy compounds, phenolic compounds and triallyl isocyanurate compounds, and a prepolymer thereof obtained by subjecting the composition to a preliminary reaction with heating to the B stage can give a cured product having excellent heat resistance of class C and flexibility.

  一种热固性树脂组合物，包含(A) 至少一种二氰胺化合物和(B) 至少一种具有一个或多个不饱和键的多价亚胺，必要时还包含(C) 至少一种环氧化合物、酚类化合物和三烯丙基异氰尿酸酯化合物中的可聚合化合物，以及通过将该组合物加热至 B 阶段进行初步反应而得到的预聚物，可以得到具有 C 级优异耐热性和柔韧性的固化产品。
• N-Cyancarbonsäureamide, Verfahren zu deren Herstellung und deren Verwendung
  申请人：CIBA-GEIGY AG

  公开号：EP0088047A1

  公开（公告）日：1983-09-07

  N-Cyancarbonsäureamidderivate, welche die Gruppierung zwei- oder dreimal im Molekül enthalten, der Formeln I bis III oder nach mehreren Methoden hergestellt. Die erfindungsgemässen N-Cyancarbonsäureamidderivate der Formeln I bis III stellen wertvolle Härtungsmittel für Epoxidharze dar.

  式 I 至式 III 的 N-氰基甲酰胺衍生物在分子中含有 2 或 3 个基团，或通过多种方法制备。 根据本发明，式 I 至式 III 的 N-氰基甲酰胺衍生物是环氧树脂的重要固化剂。
• Heat-resistant resin, thermosetting composition affording the same and prepolymer thereof
  申请人：HITACHI, LTD.

  公开号：EP0102052A2

  公开（公告）日：1984-03-07

  A polymer having excellent heat resistance and mechanical properties and comprising chemical structural units of the following formulae [I] and [II]: (polymer unit having an isomelamine ring) (polymer unit having a normal melamine ring) wherein A and B each represents an at least divalent organic group having at least one aromatic ring and m and n each represents a number of at least 1.

  一种具有优异耐热性和机械性能的聚合物，由下式[I]和[II]的化学结构单元组成： (具有异戊胺环的聚合物单元） (具有一个普通三聚氰胺环的聚合物单元） 其中 A 和 B 分别代表至少具有一个芳香环的二价有机基团，m 和 n 分别代表至少为 1 的数字。