2-溴-2-茚-1-酮 | 50870-60-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 中文名称: 2-溴-2-茚-1-酮
• 英文名称: 2-bromo-2-indene-1-one
• 英文别名: 2-bromoindenone；bromoindenone；2-bromoinden-1-one
• CAS: 50870-60-5
• 化学式: C₉H₅BrO
• 分子量: 209.042
• InChiKey: HJFISYRTQFOWNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-溴-2-茚-1-酮 在 baker's yeast 、 葡萄糖 作用下， 以 乙醇 、 水 为溶剂， 反应 24.0h， 以75%的产率得到(1S,2R)-2-bromo-2,3-dihydro-1H-inden-1-ol
  参考文献：
  名称：

  On the baker's yeast mediated transformation of α-bromoenones. Synthesis of (1S,2R)-2-bromoindan-1-ol and (2S,3S)-3-bromo-4-phenylbutan-2-ol

  摘要：

  Fermenting baker's yeast converts alpha-bromo substituted enones 7 and 10 into enantiomerically pure (1S,2R)2-bromoindan-1-ol 3 and (2S,3S)-3-bromo-4-phenylbutan-2-ol 11, respectively, through the intermediacy of the corresponding saturated ketones. Structurally related 16 provides the (2R)-allylic alcohol 17 prevalently. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00128-1
• 作为产物：
  描述：

  2,2-二溴-1-茚酮 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以63%的产率得到2-溴-2-茚-1-酮
  参考文献：
  名称：

  On the baker's yeast mediated transformation of α-bromoenones. Synthesis of (1S,2R)-2-bromoindan-1-ol and (2S,3S)-3-bromo-4-phenylbutan-2-ol

  摘要：

  Fermenting baker's yeast converts alpha-bromo substituted enones 7 and 10 into enantiomerically pure (1S,2R)2-bromoindan-1-ol 3 and (2S,3S)-3-bromo-4-phenylbutan-2-ol 11, respectively, through the intermediacy of the corresponding saturated ketones. Structurally related 16 provides the (2R)-allylic alcohol 17 prevalently. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(98)00128-1

文献信息

• [EN] INDENONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME<br/>[FR] DÉRIVÉ D'INDÉNONE ET COMPOSITION PHARMACEUTIQUE LE COMPRENANT
  申请人：KOREA RES INST CHEM TECH

  公开号：WO2011030955A1

  公开（公告）日：2011-03-17

  An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.

  式（1）的吲哚酮衍生物能够增强成骨细胞的活性，抑制破骨细胞的骨吸收作用，含有该吲哚酮衍生物或其药用盐的药用组合物可用于预防或治疗骨质疏松等骨病。
• Indenone Derivative and Pharmaceutical Composition Comprising Same
  申请人：Heo Jung Nyoung

  公开号：US20120214991A1

  公开（公告）日：2012-08-23

  An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.

  式（1）的吲哚酮衍生物能够有效增强成骨细胞的活性，抑制破骨细胞的骨吸收作用，含有该吲哚酮衍生物或其药学上可接受的盐的药物组合物对预防或治疗骨疾病如骨质疏松症具有益处。
• Indenone derivative and pharmaceutical composition comprising same
  申请人：Heo Jung Nyoung

  公开号：US08877747B2

  公开（公告）日：2014-11-04

  An indenone derivative of formula (1) is effective in enhancing the activity of osteoblastic cells and inhibiting bone resorption by osteoclastic cells, and a pharmaceutical composition comprising the indenone derivative or a pharmaceutically acceptable salt thereof is useful for preventing or treating bone diseases such as osteoporosis.

  公式（1）的吲哚酮衍生物能够有效提高成骨细胞的活性，抑制破骨细胞的骨吸收，并且含有该吲哚酮衍生物或其药学上可接受的盐的制药组合物可用于预防或治疗骨质疏松等骨疾病。
• Sket, Boris; Zupan, Marko, Collection of Czechoslovak Chemical Communications, 1988, vol. 53, # 8, p. 1745 - 1752
  作者：Sket, Boris、Zupan, Marko

  DOI：——

  日期：——
• Diels-Alder Reactions of Cyclopropenone Ketals: A Concise Tropolone Annulation Applicable to Rubrolone C Ring Introduction
  作者：Dale L. Boger、Yan Zhu

  DOI：10.1021/jo00091a040

  日期：1994.6

  A concise tropolone annulation applicable to rubrolone C ring introduction is detailed based on the room-temperature [4 + 2] cycloaddition reaction of the cyclopropenone ketal 10 with the oxygenated diene 9. Conversion of the sensitive [4 + 2] cycloadduct 11 to the norcaradiene 18, low temperature electrocyclic rearrangement to a cycloheptatrienone ketal, and tautomerization to 12 provided a fully oxygenated tropolone analogous to that found in rubrolone.