(1S,2S,3Z)-3-ethylidene-2-methylcyclobutane-1-carbonitrile | 134111-62-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1S,2S,3Z)-3-ethylidene-2-methylcyclobutane-1-carbonitrile
• CAS: 134111-62-9；134175-94-3；134175-95-4；134175-96-5；134235-04-4；134235-05-5；134235-06-6；134235-07-7
• 化学式: C₈H₁₁N
• 分子量: 121.182
• InChiKey: KLYAKPKDFKJSPC-JHVZROJUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (1S,2S,3Z)-3-ethylidene-2-methylcyclobutane-1-carbonitrile 、 臭氧 生成 (1S,2S)-2-methyl-3-oxocyclobutane-1-carbonitrile
  参考文献：
  名称：

  PASTO, DANIEL J.;SUGI, KIYOAKI D., J. ORG. CHEM., 56,(1991) N2, C. 3795-3801

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-戊二烯 、 丙烯腈 、 对苯二酚 以29%的产率得到
  参考文献：
  名称：

  PASTO, DANIEL J.;SUGI, KIYOAKI D., J. ORG. CHEM., 56,(1991) N2, C. 3795-3801

  摘要：

  DOI：

文献信息

• Cycloaddition reactions of 1,3-dimethylallene. Assignment of stereochemistry of the cycloadducts and interpretation of product distributions
  作者：Daniel J. Pasto、Kiyoaki D. Sugi、James L. Malandra

  DOI：10.1021/jo00012a007

  日期：1991.6

  The structures of the cycloadducts formed in the (2 + 2) cycloaddition reactions of 1,3-dimethylallene (13DMA) with 1,1-dichloro-2,2-difluoroethene (1122), acrylonitrile (ACN), methyl acrylate (MAC), N-phenylmaleimide (NPMI), and diethyl fumarate (DEF) and maleate (DEM) and the product distributions have been interpreted on the basis of favored conformations for diradical formation and ring closure to the cycloadducts. The stereochemistry of the ring substitution in the cycloadducts derived from ACN and MAC has been assigned on the basis of the relative chemical shifts of H-2, the relative magnitudes of the vicinal coupling constants between H-1 and H-2, the relative magnitudes of the cross-ring coupling constants between H-1 and H-3 and H-4, which are highly dependent on the conformations of the substituted methylenecyclobutane ring systems, and, in the case of the ACN cycloadducts, the results of NOE studies. The stereochemistry about the exocyclic double bonds in the cycloadducts derived from 13DMA with 1122, ACN, and MAC has been assigned on the basis of the relative magnitudes of the allylic and homoallylic coupling constants between H-1, H-3, and H-4 with H-5 and CH3b, the interpretation of which is based on the results of conformational studies carried out by molecular mechanics and ab initio MO calculations on methylenecyclobutane (28), pseudoaxial and pseudoequatorial 2-methyl-methylenecyclobutane (29a and 29e), ethylidenecyclobutane (30), and pseudoaxial and pseudoequatorial 2-methylethylidenecyclobutane (31a and 31e). The results of these calculations indicate that with 29 the pseudoaxial conformation 29a is significantly populated, while with 31 the pseudoaxial conformation 31a should be overwhelmingly populated. The trends in the relative chemical shifts and the magnitudes of the vicinal and long-range coupling constants observed in the NMR spectra of the cycloadducts derived from the reaction of 13DMA with NPMI and DEF have allowed for the assignment of the stereochemistry about the exocyclic double bonds and the ring substitution of the cycloadducts formed in these reactions. The product distributions formed in the cycloaddition reactions of 13DMA with ACN and NPMI have been analyzed by molecular mechanics calculations on the conformational preferences for formation of the diradical intermediates and on the conformational preferences of the diradical intermediates which lead directly to cycloadduct formation. The predictions of the molecular mechanics calculations are in agreement with the observed configurations in the cycloadducts formed from (R)-(-)-13DMA and ACN and consistent with the observed product distributions. Detailed analyses of the observed product distributions in the cycloaddition reactions of 13DMA with the various radicophiles lead to the conclusions that in the cycloaddition reaction with 1122 the anti,anti diradical intermediate is preferentially formed, while in the cycloadditions reactions with ACN, MAC, and NPMI the anti,syn diradical intermediates are preferentially formed. The differences in stereochemical preferences are discussed in terms of possible differences in the degree of development of the transition states for diradical intermediate formation with different dominant steric interactions.The cycloaddition with DEM produces only trans diester products and also results in the isomerization of DEM to DEF. These data imply the reversible formation of the diradical intermediates from DEF and DEM, as well as internal rotation occurring competitive with ring closure.
• Stereochemical features of the [2 + 2] cycloaddition reactions of chiral allenes. 1. The cycloaddition of chiral 1,3-dimethylallene with the monosubstituted alkenes acrylonitrile and methyl acrylate
  作者：Daniel J. Pasto、Kiyoaki D. Sugi

  DOI：10.1021/jo00012a008

  日期：1991.6

  The various stereochemical features of the (2 + 2) cycloaddition reactions of symmetrically and unsymmetrically 1,3-disubstituted allenes with 1,1- and 1,2-disubstituted and monosubstituted alkenes are discussed. Experimental studies have been carried out for the case of the cycloaddition reaction of a symmetrically substituted chiral allene (1,3-dimethylallene, 13DMA) with the monosubstituted alkenes acrylonitrile (ACN) and methyl acrylate (MAC). The cycloaddition reaction of an excess of enantioenriched 13DMA with ACN produces four optically active cycloadducts, two retaining only a small amount of the enantiomeric excess (ee) of the starting 13DMA, and two cycloadducts retaining a significantly higher level of the ee of the starting 13DMA. The recovered unreacted 13DMA possesses within experimental error the same ee as that of the starting 13DMA, implying irreversible formation of the diradical intermediates. The results are discussed in terms of the preferred conformation of approach of the ACN and 13DMA to the activated complexes for the formation of the diradical intermediates, the preferred conformations of the intermediate diradicals and their intrinsic total asymmetry, possible racemization modes of the intermediates, and the effect of the regioselectivity of ring closure to form the cycloadducts. The ee's of the cycloadducts derived with MAC are significantly higher than those of the cycloadducts derived with ACN, which is attributed to a greater diastereoselectivity in progressing to the activated complexes with MAC.