N-(4-(benzo[d]thiazol-2-yl)-3-methylphenyl)-2-chloroacetamide | 1408130-34-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: N-(4-(benzo[d]thiazol-2-yl)-3-methylphenyl)-2-chloroacetamide
• CAS: 1408130-34-6
• 化学式: C₁₆H₁₃ClN₂OS
• 分子量: 316.811
• InChiKey: DVCKWSAYQHLWPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.45
• 重原子数：
  21.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  41.99
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  N-(4-(benzo[d]thiazol-2-yl)-3-methylphenyl)-2-chloroacetamide 、 苯酚 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以65%的产率得到N-(4-(benzo[d]thiazol-2-yl)-3-methylphenyl)-2-phenoxyacetamide
  参考文献：
  名称：

  Synthesis of some N-[4-(benzothiazole-2yl) phenyl]-2-aryloxyacetamide derivatives and their anticancer activities

  摘要：

  In this study, some N-[4-(Benzothiazole-2-yl)phenyl]-2-aryloxyacetamide derivatives were prepared by reacting N-[4-(benzothiazole-2yl)phenyl]-2-chloroacetamide and different substituent phenol or thiophenol derivatives. The anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, namely 25 and 38, showed notable anticancer activity.

  DOI：

  10.3109/14756366.2011.599030
• 作为产物：
  描述：

  4-氨基-2-甲基苯甲酸 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.58h， 生成 N-(4-(benzo[d]thiazol-2-yl)-3-methylphenyl)-2-chloroacetamide
  参考文献：
  名称：

  Synthesis of some N-[4-(benzothiazole-2yl) phenyl]-2-aryloxyacetamide derivatives and their anticancer activities

  摘要：

  In this study, some N-[4-(Benzothiazole-2-yl)phenyl]-2-aryloxyacetamide derivatives were prepared by reacting N-[4-(benzothiazole-2yl)phenyl]-2-chloroacetamide and different substituent phenol or thiophenol derivatives. The anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, namely 25 and 38, showed notable anticancer activity.

  DOI：

  10.3109/14756366.2011.599030