层孔菌素A | 1403-56-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 层孔菌素A
• 英文名称: fomecin A
• 英文别名: 2,3,4-trihydroxy-6-(hydroxymethyl)benzaldehyde
• CAS: 1403-56-1
• 化学式: C₈H₈O₅
• mdl: MFCD01726512
• 分子量: 184.149
• InChiKey: MGMUFSXXHCQPGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 海关编码：
  2912499000

反应信息

• 作为反应物：
  描述：

  层孔菌素A 、 alkaline earth salt of/the/ methylsulfuric acid 生成 fomecin A tetraacetate
  参考文献：
  名称：

  Syntheses of fomecins A and B, antibiotics produced by the basidiomycete Fomes juniperinus.

  摘要：

  从没食子酸开始合成了由基枝霉菌 Fomes juniperinus SCHRENK 产生的酚类抗生素 Fomecins A 和 B。

  DOI：

  10.1248/cpb.28.1971
• 作为产物：
  描述：

  6-bromomethyl-2,3,4-trihydroxybenzaldehyde 在 platinum(IV) oxide selenium(IV) oxide 、 氢气 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 生成 层孔菌素A
  参考文献：
  名称：

  Syntheses of fomecins A and B, antibiotics produced by the basidiomycete Fomes juniperinus.

  摘要：

  从没食子酸开始合成了由基枝霉菌 Fomes juniperinus SCHRENK 产生的酚类抗生素 Fomecins A 和 B。

  DOI：

  10.1248/cpb.28.1971

文献信息

• Syntheses and antimicrobial activities of fomecins A and B, asperugin, and related compounds.
  作者：KUNIO HAYASHI、KATSUYA TOKURA、KEI OKABE、KIYOE YAMAMOTO、KATSUYA TAWARA

  DOI：10.1248/cpb.30.2860

  日期：——

  Fomecins A and B, phenolic antibiotics produced by the basidiomycete Fomes juniperinus SCHRENK, and asperugin, a metabolite of Aspergillus rugulosus, were synthesized from gallic acid. Various congeners were also prepared. Their antibacterial and antifungal activities were tested in vitro and some of the products were found to exhibit moderate antifungal activities.

  从没食子酸中合成了由基枝霉菌 Fomes juniperinus SCHRENK 产生的酚类抗生素 Fomecins A 和 B 以及曲霉代谢产物 Asperugin。还制备了各种同系物。对它们的抗菌和抗真菌活性进行了体外测试，发现其中一些产品具有中等程度的抗真菌活性。
• IRE-1alpha INHIBITORS
  申请人：MannKind Corporation

  公开号：US20140080832A1

  公开（公告）日：2014-03-20

  Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

  直接抑制IRE-1α活性的化合物、前药及其药学上可接受的盐。这些化合物和前药可用于治疗与未折叠蛋白应答相关的疾病，并可作为单一药物或联合治疗的组分。
• Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
  申请人：Proteotech Inc.

  公开号：EP1808169A2

  公开（公告）日：2007-07-18

  Polyhydroxylated aromatic compounds, and compositions containing them, are useful for the treatment of amyloidosis, especially Alzheimer's disease, and for the treatment of diseases characterized by α-synuclein fibril formation, especially Lewy body disease and Parkinson's disease.

  多羟基芳香族化合物和含有它们的组合物可用于治疗淀粉样变性病，特别是阿尔茨海默病，以及治疗以α-突触核蛋白纤维形成为特征的疾病，特别是路易体病和帕金森病。
• IRE-1A Inhibitors
  申请人：MannKind Corporation

  公开号：EP2520561A1

  公开（公告）日：2012-11-07

  Methods of treating disorders associated with unfolded protein response and methods of inhibiting IRE-1α activity are provided.

  提供了治疗与未折叠蛋白反应有关的疾病的方法和抑制 IRE-1α 活性的方法。
• Compositions containing hydroxy aromatic aldehydes and their use in treatments
  申请人：——

  公开号：US20030157154A1

  公开（公告）日：2003-08-21

  Disclosed are pharmaceutical and cosmetic compositions containing hydroxy aromatic aldehyde compounds. The disclosed compositions are useful as topical therapeutics for treating inflammatory dermatologic conditions. The disclosed compositions are also useful in transdermal and other systemic dose forms for treating other inflammatory conditions in mammals.

  所公开的是含有羟基芳香醛化合物的药物和化妆品组合物。所公开的组合物可作为局部治疗剂用于治疗皮肤炎症。所公开的组合物还可以透皮或其他全身剂量形式用于治疗哺乳动物的其他炎症。