N¹,N²-bis[4-(1-piperidinyl)-2-butynyl]phthalamide | 1385748-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹,N²-bis[4-(1-piperidinyl)-2-butynyl]phthalamide
• 英文别名: 1-N,2-N-bis(4-piperidin-1-ylbut-2-ynyl)benzene-1,2-dicarboxamide
• CAS: 1385748-60-6
• 化学式: C₂₆H₃₄N₄O₂
• 分子量: 434.582
• InChiKey: QYYOYSLDSMLYCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  64.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(4-(piperidin-1-yl)but-2-yn-1-yl)isoindoline-1,3-dione 在 一水合肼 、 盐酸 、 potassium carbonate 作用下， 以 乙醇 、 乙醚 为溶剂， 反应 3.0h， 以78%的产率得到4-(piperidin-1-yl)but-2-yn-1-amine
  参考文献：
  名称：

  Synthesis and biological evaluation of N 1,N 2-bis-[4-(t-amino)-2-butynyl]phthalamides as oxotremorine and acetylcholine antagonists

  摘要：

  A series of N (1),N (2)-bis-[4-(t-amino)-2-butynyl]phthalamides have been synthesized and investigated for the blocking of the motor effect of oxotremorine in intact mice and for their antagonistic activity towards acetylcholine on isolated guinea pig ileum preparations. All N (1),N (2)-bis-[4-(t-amino)-2-butynyl]phthalamides showed more selectivity as oxotremorine antagonists than atropine and less potent than atropine on peripheral cholinergic antagonistic activity.

  DOI：

  10.1007/s00044-012-0147-2

文献信息

• Synthesis and biological evaluation of N 1,N 2-bis-[4-(t-amino)-2-butynyl]phthalamides as oxotremorine and acetylcholine antagonists
  作者：Zuhair Muhi-eldeen、Elham Al-Kaissi、Hanan Ghantous

  DOI：10.1007/s00044-012-0147-2

  日期：2013.4

  A series of N (1),N (2)-bis-[4-(t-amino)-2-butynyl]phthalamides have been synthesized and investigated for the blocking of the motor effect of oxotremorine in intact mice and for their antagonistic activity towards acetylcholine on isolated guinea pig ileum preparations. All N (1),N (2)-bis-[4-(t-amino)-2-butynyl]phthalamides showed more selectivity as oxotremorine antagonists than atropine and less potent than atropine on peripheral cholinergic antagonistic activity.