2-羟基-5-[4-(羟甲基)苯基]苯甲醛 | 1098984-09-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-羟基-5-[4-(羟甲基)苯基]苯甲醛
• 英文名称: 2-hydroxy-5-[4-(hydroxymethyl)phenyl]benzaldehyde
• 英文别名: 5-(4-Hydroxymethylphenyl)salicylaldehyde；2-Formyl-4-(4-hydroxymethylphenyl)phenol
• CAS: 1098984-09-8
• 化学式: C₁₄H₁₂O₃
• 分子量: 228.247
• InChiKey: VJSWSPCDTGCFHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-羟基-5-[4-(羟甲基)苯基]苯甲醛 、 4-溴乙酰基-3-氟苯硼酸 在 potassium carbonate 作用下， 以 丁酮 为溶剂， 反应 20.25h， 以64%的产率得到[3-fluoro-4-({5-[4-(hydroxymethyl)phenyl]-1-benzofuran-2-yl}carbonyl)phenyl]boronic acid
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR INHIBITING GROUP II INTRON RNA
  [FR] COMPOSITIONS ET MÉTHODES POUR INHIBER DES ARN D'INTRON DE GROUPE II

  摘要：

  本发明提供了用于抑制II类内含子剪接的组合物和方法，用于治疗或预防与携带活跃II类内含子的生物体相关的疾病或紊乱。本发明还提供了用于抑制II类内含子剪接，以抑制、预防或减少携带活跃II类内含子的生物体生长的组合物和方法。

  公开号：

  WO2019147894A1

文献信息

• Inhibitors of protein kinase for the treatment of disease
  申请人：——

  公开号：US20030187007A1

  公开（公告）日：2003-10-02

  The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to phenol- and hydroxynaphthalene-based compounds and pharmaceutical compositions comprising these compounds.

  本发明部分涉及使用基于酚和羟基萘的化合物调节蛋白激酶功能的方法。这些方法涉及表达蛋白激酶的细胞。此外，该发明描述了使用本发明鉴定的化合物预防和治疗生物体中与蛋白激酶相关的异常情况的方法。此外，该发明涉及基于酚和羟基萘的化合物以及包含这些化合物的药物组合物。
• INHIBITORS OF PROTEIN KINASE FOR THE TREATMENT OF DISEASE
  申请人：LG Biomedical Institute

  公开号：EP1412327A2

  公开（公告）日：2004-04-28
• COMPOSITIONS AND METHODS FOR INHIBITING GROUP II INTRON RNA
  申请人：YALE UNIVERSITY

  公开号：US20210139512A1

  公开（公告）日：2021-05-13

  The present invention provides compositions and methods for inhibiting group II intron splicing for treating or preventing a disease or disorder associated with an organism harboring an active group II intron. The present invention also provides compositions and methods for inhibiting group II intron splicing for inhibiting, preventing or reducing growth of an organism harboring an active group II intron.
• [EN] INHIBITORS OF PROTEIN KINASE FOR THE TREATMENT OF DISEASE<br/>[FR] INHIBITEURS DE LA PROTEINE KINASE DESTINES AU TRAITEMENT D'UNE MALADIE
  申请人：LG BIOMEDICAL INST

  公开号：WO2002096867A2

  公开（公告）日：2002-12-05

  The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to phenol- and hydroxynaphthalene-based compounds and pharmaceutical compositions comprising these compounds.
• [EN] COMPOSITIONS AND METHODS FOR INHIBITING GROUP II INTRON RNA<br/>[FR] COMPOSITIONS ET MÉTHODES POUR INHIBER DES ARN D'INTRON DE GROUPE II
  申请人：UNIV YALE

  公开号：WO2019147894A1

  公开（公告）日：2019-08-01

  The present invention provides compositions and methods for inhibiting group II intron splicing for treating or preventing a disease or disorder associated with an organism harboring an active group II intron. The present invention also provides compositions and methods for inhibiting group II intron splicing for inhibiting, preventing or reducing growth of an organism harboring an active group II intron.

  本发明提供了用于抑制II类内含子剪接的组合物和方法，用于治疗或预防与携带活跃II类内含子的生物体相关的疾病或紊乱。本发明还提供了用于抑制II类内含子剪接，以抑制、预防或减少携带活跃II类内含子的生物体生长的组合物和方法。