7,8-dihydroxyisoquinoline-3-carboxylic acid methyl ester hydrochloride | 142822-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 7,8-dihydroxyisoquinoline-3-carboxylic acid methyl ester hydrochloride
• 英文别名: 3-Isoquinolinecarboxylic acid, 7,8-dihydroxy-, methyl ester, hydrochloride；methyl 7,8-dihydroxyisoquinoline-3-carboxylate;hydrochloride
• CAS: 142822-88-6
• 化学式: C₁₁H₉NO₄*ClH
• 分子量: 255.658
• InChiKey: YGQBEVKPTRQMAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.85
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  79.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 5-bromo-7,8-dihydroxytetrahydroisoquinoline-3-carboxylate hydrochloride 在 palladium on activated charcoal 盐酸 、 manganese(IV) oxide 、 硫酸 、 氢气 、 溶剂黄146 作用下， 以 甲醇 、 甲苯 为溶剂， 25.0 ℃ 、275.79 kPa 条件下， 反应 5.5h， 生成 7,8-dihydroxyisoquinoline-3-carboxylic acid methyl ester hydrochloride
  参考文献：
  名称：

  Burke, Terrence R.; Russ, Pamela L.; Marquez, Victor E., Heterocycles, 1992, vol. 34, # 4, p. 757 - 764

  摘要：

  DOI：

文献信息

• A METHOD FOR THE TREATMENT OF HYPERPROLIFERATIVE EPITHELIAL SKIN DISEASES BY TOPICAL APPLICATION OF HYDROXYLATED AROMATIC PROTEIN CROSS-LINKING COMPOUNDS
  申请人：THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP0809493A1

  公开（公告）日：1997-12-03
• US5610185A
  申请人：——

  公开号：US5610185A

  公开（公告）日：1997-03-11
• [EN] POLYHYDROXYLATED NAPHTHYL 2-CARBOXYLATE, AND QUINOLYL AND ISOQUINOLYL 3-CARBOXYLATE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS<br/>[FR] DERIVES DE 2-CARBOXYLATE DE NAPHTYLE POLYHYDROXYLE ET DE 3-CARBOXYLATE DE QUINOLYLE ET D'ISOQUINOLYLE UTILISES COMME INHIBITEURS DE LA PROTEINE-TYROSINE-KINASE
  申请人：THE GOVERNMENT OF THE UNITED STATES as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：WO1994003432A1

  公开（公告）日：1994-02-17

  (EN) Polyhydroxylated naphthyl 2-carboxylate, and isoquinoline and quinoline 3-carboxylate derivatives are provided which possess protein tyrosine kinase inhibitory activity. Pharmaceutical compositions containing the compounds as well as methods of treating neoplastic and immune diseases, which diseases require protein tyrosine kinase for cell proliferation, are also provided.(FR) L'invention concerne des dérivés de 2-carboxylate de naphtyle polyhydroxylé et de 3-carboxylate d'isoquinoléine et de quinoléine possédant une efficacité d'inhibition de la protéine-tyrosine-kinase. L'invention concerne également des compositions pharmaceutiques contenant les composés, ainsi que des procédés de traitement de maladies néoplasiques et immunes, lesdites maladies nécessitant la protéine-tyrosine-kinase pour la prolifération cellulaire.
• [EN] A METHOD FOR THE TREATMENT OF HYPERPROLIFERATIVE EPITHELIAL SKIN DISEASES BY TOPICAL APPLICATION OF HYDROXYLATED AROMATIC PROTEIN CROSS-LINKING COMPOUNDS<br/>[FR] PROCEDE POUR TRAITER LES LESIONS EPITHELIALES HYPERPROLIFERATIVES DE LA PEAU PAR APPLICATION TOPIQUE DE COMPOSES DE RETICULATION DE PROTEINES AROMATIQUES HYDROXYLES
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：WO1996025159A1

  公开（公告）日：1996-08-22

  (EN) The present invention relates to a method of treating hyperproliferative epithelial lesions by topical administration. The method prevents growth and actively cross-links these aberrant cells, thereby killing the cells. The present invention is useful in control and prevention of hyperproliferative epithelial disorders, such as HPV-infected cell lesions, actinic keratosis, melanomas, and malignant and pre-malignant carcinomas.(FR) Cette invention se rapporte à un procédé pour traiter les lésions épithéliales hyperprolifératives de la peau par administration topique. Ce procédé empêche la croissance et entraîne la réticulation active de ces cellules aberrantes, afin de les détruire. Cette invention permet de combattre et prévenir les troubles épithéliaux hyperprolifératifs, telles que les lésions cellulaires infectées par HPV, la kératose actinique, les mélanomes et les carcinomes malins et prémalins.
• Burke, Terrence R.; Russ, Pamela L.; Marquez, Victor E., Heterocycles, 1992, vol. 34, # 4, p. 757 - 764
  作者：Burke, Terrence R.、Russ, Pamela L.、Marquez, Victor E.

  DOI：——

  日期：——