2-((2-(diethylamino)ethyl)(propyl)amino)ethan-1-ol | 96464-41-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-((2-(diethylamino)ethyl)(propyl)amino)ethan-1-ol
• 英文别名: 2-[[2-(Diethylamino)ethyl]propylamino]ethanol；2-[2-(diethylamino)ethyl-propylamino]ethanol
• CAS: 96464-41-4
• 化学式: C₁₁H₂₆N₂O
• 分子量: 202.34
• InChiKey: SMMHLSCDIDLXGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-((2-(diethylamino)ethyl)(propyl)amino)ethan-1-ol 在 氯化亚砜 作用下， 生成 N-(2-Chloro-ethyl)-N',N'-diethyl-N-propyl-ethane-1,2-diamine
  参考文献：
  名称：

  与“混合”配体的五配位。第七部分 具有N 2 OP，N 2 SP和NOAs 2供体组的不对称三脚架配体的钴（II）和镍（II）配合物

  摘要：

  不对称'三角架'配体ñ - [2-（二苯基膦基）乙基] - ñ - （2-甲氧基乙基） - ñ ' ñ ' - diethylthylenediamine（我;供体集合N 2 OP）和ñ - [2-（二苯基膦基）乙基） - ñ - [2-（甲硫基）乙基] - ñ ' ñ '-diethylethylenediamine（II;供体组N 2，SP）形式的钴（II）和镍（II）与通式配合物[MLX] BPH 4（X =卤素或NCS）。钴（二）络合物在固态和溶液中都是高自旋和五坐标的，可能是三角双锥体。具有L =（I），X = 1或NCS的[NiLX] BPh 4配合物是低自旋的，并且在固态下可能具有五坐标，且方锥体立体化学变形。认为所有其他镍配合物均具有正方形平面结构，其中配体L与NNP供体组相连。源自配体NN-双-（2-二苯基-砷基乙基）-2-甲氧基乙胺（III；供体组NOAs 2）的配合物[Ni（NOAs

  DOI：

  10.1039/j19710001487
• 作为产物：
  描述：

  2-(2-二乙基氨基乙基氨基)乙醇 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2-((2-(diethylamino)ethyl)(propyl)amino)ethan-1-ol
  参考文献：
  名称：

  A New Method for the Preparation of Piperazines. II. Preparation ofN,N′-Disubstituted Piperazines

  摘要：

  DOI：

  10.1246/bcsj.34.655

文献信息

• COMPOUND, SALT THEREOF AND LIPID PARTICLES
  申请人：FUJIFILM Corporation

  公开号：EP3805198A1

  公开（公告）日：2021-04-14

  An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents -NR1- or -O-, R1 represents a hydrogen atom, a hydrocarbon group, or the like, R2 and R3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R4, R5, R6, R7, R8, R9, R10, R11, and R12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R4 and R5, R10 and R5, R5 and R12, R4 and R6, R5 and R6, R6 and R7, R6 and R10, R12 and R7, and R7 and R8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a + b is equal to or greater than 1, and c + d is equal to or greater than 1.

  本发明的目的是提供一种化合物或其盐类构成的脂质微粒，该脂质微粒可实现较高的核酸包封率和核酸的良好递送，并提供可实现较高的核酸包封率和核酸的良好递送的脂质微粒。根据本发明的一个方面，提供了一种由式（1）代表的化合物或其盐。 式中，X代表-NR1-或-O-，R1代表氢原子、烃基或类似物，R2和R3各自独立地代表氢原子、烃基或类似物，R4、R5、R6、R7、R8、R9、R10、R11和R12各自独立地代表氢原子或烷基、R4和R5之间任意一对或多对的基团、R10 和 R5、R5 和 R12、R4 和 R6、R5 和 R6、R6 和 R7、R6 和 R10、R12 和 R7 以及 R7 和 R8 中的任意一对或多对基团可彼此相连，形成可包含 O 原子的 4 至 7 元环，a、b、c 和 d 各自独立地代表 0 至 3 的整数，a + b 等于或大于 1，c + d 等于或大于 1。
• COMPOUND OR SALT THEREOF AND LIPID PARTICLES
  申请人：FUJIFILM Corporation

  公开号：US20210085604A1

  公开（公告）日：2021-03-25

  An object of the present invention is to provide a compound or a salt thereof constituting lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids, and to provide lipid particles that can achieve a high nucleic acid encapsulation rate and excellent delivery of nucleic acids. According to an aspect of the present invention, a compound represented by Formula (1) or a salt thereof is provided. In the formula, X represents —NR 1 — or —O—, R represents a hydrogen atom, a hydrocarbon group, or the like, R 2 and R 3 each independently represent a hydrogen atom, a hydrocarbon group, or the like, R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , and R 12 each independently represent a hydrogen atom or an alkyl group, groups in any one or more pairs among R 4 and R 5 , R 10 and R 5 , R 5 and R 12 , R 4 and R 6 , R 5 and R 6 , R 6 and R 7 , R 6 and R 10 , R 12 and R 7 , and R 7 and R 8 may be linked to each other to form a 4- to 7-membered ring which may contain an O atom, a, b, c, and d are each independently represent an integer of 0 to 3, a+b is equal to or greater than 1, and c+d is equal to or greater than 1.
• A New Method for the Preparation of Piperazines. II. Preparation of<i>N</i>,<i>N</i>′-Disubstituted Piperazines
  作者：Kazuo Nakajima

  DOI：10.1246/bcsj.34.655

  日期：1961.5
• Five-co-ordination with ‘hybrid’ ligands. Part VII. Cobalt(<scp>II</scp>) and nickel(<scp>II</scp>) complexes with asymmetric tripod ligands having N₂OP, N₂SP, and NOAs₂donor sets
  作者：R. Morassi、L. Sacconi

  DOI：10.1039/j19710001487

  日期：——

  -N′N′-diethylethylenediamine (II; donor set N2SP) form cobalt(II) and nickel(II) complexes with general formula [MLX]BPh4(X = halogen or NCS). The cobalt(II) complexes are high-spin and five-co-ordinate, probably trigonal bipyramidal, both in the solid state and in solution. The [NiLX]BPh4 complexes with L =(I), X = l or NCS are low-spin and probably five-co-ordinate in the solid state with a distorted

  不对称'三角架'配体ñ - [2-（二苯基膦基）乙基] - ñ - （2-甲氧基乙基） - ñ ' ñ ' - diethylthylenediamine（我;供体集合N 2 OP）和ñ - [2-（二苯基膦基）乙基） - ñ - [2-（甲硫基）乙基] - ñ ' ñ '-diethylethylenediamine（II;供体组N 2，SP）形式的钴（II）和镍（II）与通式配合物[MLX] BPH 4（X =卤素或NCS）。钴（二）络合物在固态和溶液中都是高自旋和五坐标的，可能是三角双锥体。具有L =（I），X = 1或NCS的[NiLX] BPh 4配合物是低自旋的，并且在固态下可能具有五坐标，且方锥体立体化学变形。认为所有其他镍配合物均具有正方形平面结构，其中配体L与NNP供体组相连。源自配体NN-双-（2-二苯基-砷基乙基）-2-甲氧基乙胺（III；供体组NOAs 2）的配合物[Ni（NOAs