N-benzyl-N-methyl-2-methylallylamine | 64824-85-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-N-methyl-2-methylallylamine
• 英文别名: N-benzyl-N,2-dimethylprop-2-en-1-amine；Methyl-benzyl-methallylamin
• CAS: 64824-85-7
• 化学式: C₁₂H₁₇N
• 分子量: 175.274
• InChiKey: LZFFEXINDCZKKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  ethyl N-benzyl-N-methylglycinate 在 甲基锂 、 silica gel 作用下， 以 四氯化碳 为溶剂， 反应 6.17h， 生成 N-benzyl-N-methyl-2-methylallylamine
  参考文献：
  名称：

  Trisubstituted (stannylmethyl)lithium as a methylene double anion equivalent. Reaction with esters

  摘要：

  DOI：

  10.1021/jo00241a016

文献信息

• Electrochemical Synthesis of Allylic Amines from Terminal Alkenes and Secondary Amines
  作者：Diana J. Wang、Karina Targos、Zachary K. Wickens

  DOI：10.1021/jacs.1c11763

  日期：2021.12.29

  electrophilic adduct between thianthrene and the alkene substrates. Treatment of these adducts with aliphatic amine nucleophiles and base provides allylic amine products in high yield. This synthetic strategy is also amenable to functionalization of feedstock gaseous alkenes at 1 atm. In the case of 1-butene, high Z-selective crotylation is observed. This strategy, however, is not limited to the synthesis of

  烯丙基胺是合成各种具有生物活性的胺产品的重要合成目标。目前的烯丙基 C-H 胺化策略在可行的N取代基方面仍然有限。在此，我们公开了一种新的电化学方法，通过偶联两种丰富的起始材料：仲胺和未活化的烯烃来制备脂肪族烯丙胺。这种氧化转化通过在噻蒽和烯烃底物之间电化学产生亲电加合物而进行。用脂肪胺亲核试剂和碱处理这些加合物以高产率提供烯丙基胺产物。这种合成策略也适用于原料气态烯烃在 1 个大气压下的官能化。在 1-丁烯的情况下，高Z观察到选择性巴豆酰化。然而，这种策略并不局限于简单构建块的合成；复杂的生物活性分子既适合作为烯烃偶联配偶体，也适合作为胺偶联配偶体。初步的机理研究表明乙烯基蒽盐是关键的反应中间体。
• SUBSTITUTED INTERNAL VINYL-BORONIC ACIDS AND BORONIC ACID DERIVATIVES
  申请人：Math Shivanand K.

  公开号：US20120041193A1

  公开（公告）日：2012-02-16

  Disclosed herein are vinyl-bromides, vinyl-boronic acids and vinyl-boronic acid derivatives useful as synthetic intermediates for the preparation of therapeutic agents. Also disclosed are methods of synthesis of vinyl-bromides, vinyl-boronic acids and vinyl-boronic acid derivatives.

  本文披露了乙烯基溴化物、乙烯基硼酸和乙烯基硼酸衍生物，它们可用作合成中间体，用于制备治疗剂。还披露了合成乙烯基溴化物、乙烯基硼酸和乙烯基硼酸衍生物的方法。
• ANTI-PULMONARY TUBERCULOSIS NITROIMIDAZOLE DERIVATIVE
  申请人：Medshine Discovery Inc.

  公开号：EP3252059A1

  公开（公告）日：2017-12-06

  Disclosed is a substituted nitroimidazole derivative, which is mainly used for treating related diseases caused by mycobacterial infections, such as Mycobacterium tuberculosis, especially being suitable for diseases caused by resistant Mycobacterium tuberculosis.

  本发明公开了一种取代的硝基咪唑衍生物，主要用于治疗结核分枝杆菌等分枝杆菌感染引起的相关疾病，尤其适用于耐药结核分枝杆菌引起的疾病。
• γ-Functionalised β-methylene organolithium compounds from 3-chloro-2-(chloromethyl)propene: Synthetic applications
  作者：Diego J Ramón、Miguel Yus

  DOI：10.1016/s0040-4020(01)80206-4

  日期：1993.1

  The reaction of functionalised methallylic chlorides 1 with an excess of lithium powder and a catalytic amount of naphthalene (8 mol %) in the presence of a carbonyl compound (Barbier-type conditions) at -78-degrees-C leads, after hydrolysis with water, to the corresponding polyfunctionalised compounds 2. Starting materials 1 are easily available from 3-chloro-2-(chloromethyl)propene by nucleophilic substitution.
• Trisubstituted (stannylmethyl)lithium as a methylene double anion equivalent. Reaction with esters
  作者：Tadashi Sato、Hiroharu Matsuoka、Tsutomu Igarashi、Masafumi Minomura、Eigoro Murayama

  DOI：10.1021/jo00241a016

  日期：1988.3