3-butenyldipropylamine | 959264-00-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-butenyldipropylamine
• 英文别名: Dipropylamine, N-(3-butenyl)-；N,N-dipropylbut-3-en-1-amine
• CAS: 959264-00-7
• 化学式: C₁₀H₂₁N
• 分子量: 155.283
• InChiKey: XXOALPAUJFHPOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-butenyldipropylamine 在 magnesium hydride 、 氯化锆(IV) 作用下， 以 四氢呋喃 为溶剂， 以18.2%的产率得到
  参考文献：
  名称：

  Angermund, Klaus; Bogdanovic, Borislav; Koppetsch, Gudrun, Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1986, vol. 41, # 4, p. 455 - 466

  摘要：

  DOI：
• 作为产物：
  描述：

  (dipropylamino)methoxymethane 在 potassium carbonate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 14.5h， 生成 3-butenyldipropylamine
  参考文献：
  名称：

  Reactions of Allylsilanes with Iminium Salts:  Ene Reactions with Inverse Electron Demand

  摘要：

  The N,N-dialkylmethyleneammonium hexachloroantimonates 1-SbCl6- react with allyltrimethylsilane (2a) in dichloromethane to give the alkylideneammonium ions 3 and 3' via ene reactions with inverse electron demand, where the allyltrimethylsilane (2a) behaves as enophile. Under the same conditions (2-methylallyl)trimethylsilane (2b) undergoes ordinary ene reactions with iminium ions, with the allylsilane 2b acting as the ene component. The different course of the ene reactions is explained by the varied steric strain in the pericyclic transition states 14-18. S(E)2' products, which are the main products under more nucleophilic reaction conditions, have only been detected in trace amounts.

  DOI：

  10.1021/jo960516u

文献信息

• Bimetallic Coordination Insertion Polymerization of Unprotected Polar Monomers: Copolymerization of Amino Olefins and Ethylene by Dinickel Bisphenoxyiminato Catalysts
  作者：Madalyn R. Radlauer、Aya K. Buckley、Lawrence M. Henling、Theodor Agapie

  DOI：10.1021/ja4004816

  日期：2013.3.13

  bisphenoxyiminato complexes based on highly substituted p- and m-terphenyl backbones were synthesized, and the corresponding atropisomers were isolated. In the presence of a phosphine scavenger, Ni(COD)2, the phosphine-ligated syn-dinickel complexes copolymerized α-olefins and ethylene in the presence of amines to afford 0.2-1.3% α-olefin incorporation and copolymerized amino olefins and ethylene with a similar

  合成了基于高度取代的对三联苯和间三联苯主链的双苯氧基亚氨基二镍配合物，并分离出相应的阻转异构体。在膦清除剂 Ni(COD)2 的存在下，膦连接的顺丁镍配合物在胺存在下共聚 α-烯烃和乙烯，得到 0.2-1.3% 的 α-烯烃结合和共聚氨基烯烃和乙烯类似的掺入范围（0.1-0.8%）。本刚性催化剂为极性单体的插入聚合提供了一种双金属策略，而不会掩盖杂原子基团。通过比较顺式和反阻转异构体以及对和间三联苯体系，研究了催化剂结构对反应性的影响。
• [EN] 5- AND 6-AZAINDOLE COMPOUNDS FOR INHIBITION OF BCR-ABL TYROSINE KINASES<br/>[FR] COMPOSÉS DE 5- ET 6-AZAINDOLE POUR L'INHIBITION DE TYROSINE KINASES BCR-ABL
  申请人：ENLIVEN THERAPEUTICS INC

  公开号：WO2022076975A1

  公开（公告）日：2022-04-14

  The present disclosure relates to compounds and compositions for inhibition of Bcr- Abl tyrosine kinases, methods of preparing said compounds and compositions, and their use in the treatment of various cancers, such as chronic myeloid leukemia (CML).

  本公开涉及抑制Bcr-Abl酪氨酸激酶的化合物和组合物，制备该化合物和组合物的方法，以及它们在治疗各种癌症，如慢性髓细胞白血病（CML）中的应用。
• ANGERMUND, K.;BOGDANOVIC, B.;KOPPETSCH, G.;KRUEGER, C.;MYNOTT, R.;SCHWICK+, Z. NATURFORSCH., 1986, 41, N 4, 455-466
  作者：ANGERMUND, K.、BOGDANOVIC, B.、KOPPETSCH, G.、KRUEGER, C.、MYNOTT, R.、SCHWICK+

  DOI：——

  日期：——
• Angermund, Klaus; Bogdanovic, Borislav; Koppetsch, Gudrun, Zeitschrift fur Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, 1986, vol. 41, # 4, p. 455 - 466
  作者：Angermund, Klaus、Bogdanovic, Borislav、Koppetsch, Gudrun、Krueger, Carl、Mynott, Richard、et al.

  DOI：——

  日期：——
• Reactions of Allylsilanes with Iminium Salts:  Ene Reactions with Inverse Electron Demand
  作者：Armin R. Ofial、Herbert Mayr

  DOI：10.1021/jo960516u

  日期：1996.1.1

  The N,N-dialkylmethyleneammonium hexachloroantimonates 1-SbCl6- react with allyltrimethylsilane (2a) in dichloromethane to give the alkylideneammonium ions 3 and 3' via ene reactions with inverse electron demand, where the allyltrimethylsilane (2a) behaves as enophile. Under the same conditions (2-methylallyl)trimethylsilane (2b) undergoes ordinary ene reactions with iminium ions, with the allylsilane 2b acting as the ene component. The different course of the ene reactions is explained by the varied steric strain in the pericyclic transition states 14-18. S(E)2' products, which are the main products under more nucleophilic reaction conditions, have only been detected in trace amounts.