3-(Benzylsulfanylmethyl)-7-methyl-2-(4-pyridyl)imidazo[1,2-a]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 3-(Benzylsulfanylmethyl)-7-methyl-2-(4-pyridyl)imidazo[1,2-a]pyridine
• 英文别名: 3-(benzylsulfanylmethyl)-7-methyl-2-pyridin-4-ylimidazo[1,2-a]pyridine
• 化学式: C₂₁H₁₉N₃S
• 分子量: 345.468
• InChiKey: DIOWNVFAEUPOMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7-methyl-2-pyridin-4-ylimidazo[1,2-a]pyridine 在 sodium acetate 作用下， 以 水 、 溶剂黄146 为溶剂， 反应 8.0h， 生成 3-(Benzylsulfanylmethyl)-7-methyl-2-(4-pyridyl)imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Influence of 2-Substituent on the Activity of Imidazo[1,2-a] Pyridine Derivatives Against Human Cytomegalovirus

  摘要：

  The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by H-1 and C-13 NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00347-9

文献信息

• Influence of 2-Substituent on the Activity of Imidazo[1,2-a] Pyridine Derivatives Against Human Cytomegalovirus
  作者：Sylvie Mavel、Jean-Louis Renou、Christophe Galtier、Hassan Allouchi、Robert Snoeck、Graciella Andrei、Erik De Clercq、Jan Balzarini、Alain Gueiffier

  DOI：10.1016/s0968-0896(01)00347-9

  日期：2002.4

  The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by H-1 and C-13 NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent. (C) 2002 Elsevier Science Ltd. All rights reserved.