5-methyl-7-methylmercapto-3-phenylthiazolo<4,5-d>pyrimidin-2(3H)-thione | 141622-19-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-methyl-7-methylmercapto-3-phenylthiazolo<4,5-d>pyrimidin-2(3H)-thione
• 英文别名: 5-Methyl-7-methylsulfanyl-3-phenyl-thiazolo[4,5-d]pyrimidine-2-thione；5-methyl-7-methylsulfanyl-3-phenyl-[1,3]thiazolo[4,5-d]pyrimidine-2-thione
• CAS: 141622-19-7
• 化学式: C₁₃H₁₁N₃S₃
• 分子量: 305.448
• InChiKey: RRTSJGRIPSAHMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  112
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  7-chloro-5-methyl-3-phenylthiazolo<4,5-d>pyrimidin-2(3H)-thione 在 sodium hydroxide 、 sodium acetate 、 硫脲 作用下， 以 乙醇 为溶剂， 反应 3.08h， 生成 5-methyl-7-methylmercapto-3-phenylthiazolo<4,5-d>pyrimidin-2(3H)-thione
  参考文献：
  名称：

  El-Dean, Adel M. Kamal, Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 66, # 14, p. 21 - 28

  摘要：

  DOI：

文献信息

• Potential anti-microbials. II. Synthesis and in vitro anti-microbial evaluation of some thiazolo[4,5-d]pyrimidines
  作者：ESAM Badawey、SM Rida、AA Hazza、HTY Fahmy、YM Gohar

  DOI：10.1016/0223-5234(93)90002-v

  日期：1993.1

  Some thiazolo[4,5-d]pyrimidines were prepared in order to investigate their antimicrobial activity. A significant inhibitory effect was recorded for many compounds against Staphylococcus aureus ATCC 25923 (3, 6, 9a; MIC = 10-20 mug/ml), Escherichia coli ATCC 25922 (3,5,9b, MIC = 40 mug/ml) and Candida albicans DSM 70443 (6, MIC = 50 mug/ml).
• El-Dean, Adel M. Kamal, Phosphorus, Sulfur and Silicon and the Related Elements, 1992, vol. 66, # 14, p. 21 - 28
  作者：El-Dean, Adel M. Kamal

  DOI：——

  日期：——