bromoacetaldehyde dibenzylacetal | 2020-38-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bromoacetaldehyde dibenzylacetal
• 英文别名: Brom-acetaldehyd-dibenzylacetal；2-Brom-1.1-dibenzyloxy-aethan；2-bromoethanal dibenzyl acetal；(2-bromo-1-phenylmethoxyethoxy)methylbenzene
• CAS: 2020-38-4
• 化学式: C₁₆H₁₇BrO₂
• 分子量: 321.214
• InChiKey: SMACYULEKOJORC-UHFFFAOYSA-N

物化性质

• 沸点：
  190-195 °C(Press: 2 Torr)
• 密度：
  1.2181 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  bromoacetaldehyde dibenzylacetal 在 臭氧 作用下， 以 甲醇 为溶剂， 生成 5,5-bis(phenylmethoxy)pentan-2-one
  参考文献：
  名称：

  Cyclopentanoid synthesis via directed cationic cyclizations. Efficient generation and rearrangement of the intermediate cyclohexyl cation

  摘要：

  DOI：

  10.1021/jo00255a052
• 作为产物：
  描述：

  乙酸乙烯酯 在 溴 作用下， 生成 bromoacetaldehyde dibenzylacetal
  参考文献：
  名称：

  Ketene Acetals. XI. The Pyrolysis of Ketene Acetals and Orthoesters

  摘要：

  DOI：

  10.1021/ja01263a001

文献信息

• Stereoselective Addition of Titanium Enolates to Functionalized Acetals: A Novel Approach to the γ-Amino Acid of Bistramides and FR252921
  作者：Pedro Romea、Fèlix Urpí、Erik Gálvez、Ricard Parelló

  DOI：10.1055/s-0028-1087351

  日期：2008.12

  Dialkyl acetals containing other functional groups can participate in stereoselective coupling reactions with chiral titanium enolates. Such an approach provides the protected γ-amino acid present in bistramides and FR252921 in a highly efficient manner.

  含有其他功能团的二烷基乙缩醛可以与手性钛烯醇盐参与立体选择性耦合反应。这种方法高效地提供了在双三肽和FR252921中存在的保护γ-氨基酸。
• Use of organophosphorous compounds for producing a medicament for treating infections
  申请人：——

  公开号：US20030144249A1

  公开（公告）日：2003-07-31

  The invention relates to the use of organophosphorus compounds of the general formula (I) 1 wherein B is selected from the group which consists of group 2 and group R 1 —N═A—  (III) and wherein A is selected from the group which consists of an alkyleneamine residue, an alkenyleneamine residue, a hydroxyalkyleneamine residue, an alkyleneimine residue, an alkenyleneimine residue and a hydroxyalkyleneimine residue, wherein the nitrogen atom is located in the chain which links the phosphorus atom with the nitrogen atom of the group 3 or group R 1 —N═, for the therapeutic and prophylactic treatment of infections in humans and animals caused by viruses, bacteria, fungi and parasites and pharmaceutical preparations which contain these compounds as the active ingredient, and to the use thereof as a fungicide, bactericide and herbicide in plants.

  本发明涉及使用具有通式（I）的有机磷化合物，其中B从由群2和群R1-N═A-（III）组成的群中选择，其中A从由烷基胺基，烯基胺基，羟基烷基胺基，烷基亚胺基，烯基亚胺基和羟基烷基亚胺基组成的群中选择，其中氮原子位于将磷原子与群3或群R1-N═的氮原子链接的链中，用于治疗和预防由病毒，细菌，真菌和寄生虫引起的人类和动物感染以及含有这些化合物作为活性成分的制药制剂，以及在植物中作为杀真菌剂，杀菌剂和除草剂的用途。
• Enantioselective enzymatic synthesis of the anti-viral agent lamivudine (3TC™)
  作者：John Milton、Stephen Brand、Martin F. Jones、Christopher M. Rayner

  DOI：10.1016/0040-4039(95)01380-z

  日期：1995.9

  A novel enzymatic resolution of alpha-acetoxysulfides has been used as the key step in the synthesis of the important antiviral nucleoside analogue lamivudine. The synthesis proceeds via a configurationally stable hemithioacetal which cyclises in situ to form the required oxathiolane nucleus, which can then be converted into the target nucleoside in 4 steps.
• McElvain; Anthes; Shapiro, Journal of the American Chemical Society, 1942, vol. 64, p. 2529
  作者：McElvain、Anthes、Shapiro

  DOI：——

  日期：——
• Mamedov,S.; Agaev,A.S., Journal of Organic Chemistry USSR (English Translation), 1965, vol. 1, # 1, p. 67 - 68
  作者：Mamedov,S.、Agaev,A.S.

  DOI：——

  日期：——