Aminomesembran | 94861-36-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Aminomesembran
• 英文别名: 3a-(3,4-dimethoxy-phenyl)-1-methyl-octahydro-indol-6-ylamine；3a-(3,4-dimethoxyphenyl)-1-methyl-3,4,5,6,7,7a-hexahydro-2H-indol-6-amine
• CAS: 94861-36-6
• 化学式: C₁₇H₂₆N₂O₂
• 分子量: 290.406
• InChiKey: XUXKBUJTXROVQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  47.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-cyano-N'-(3,5-dichlorophenyl)-O-phenylisourea 、 Aminomesembran 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 0.08h， 生成 N-cyano-N'-(3,5-dichlorophenyl)-N''-[(3aS,6R,7aS)-3a-(3,4-dimethoxyphenyl)-1-methyloctahydro-1H-indol-6-yl]guanidine 、 N-cyano-N'-(3,5-dichlorophenyl)-N''-[(3aR,6S,7aR)-3a-(3,4-dimethoxyphenyl)-1-methyloctahydro-1H-indol-6-yl]guanidine
  参考文献：
  名称：

  [EN] Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R)
  [FR] UREE-OCTAHYDROINDOLES SUBSTITUES UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR 1 DE L'HORMONE CONCENTRANT LA MELANINE (MCH1R)

  摘要：

  该发明涉及通式（I）的化合物，其中R0、R1、R2、R3、R4、R5、R6、R7、R8、R9、Ar和X如描述中所定义，或其药学上可接受的盐、水合物、几何异构体、消旋体、互变异构体、光学异构体、N-氧化物及其前药形式。这些化合物可用于治疗或预防与MCH1R受体相关的疾病，并用于调节食欲。该发明还涉及该用途以及包含通式（I）化合物的药物配方。

  公开号：

  WO2005051381A1

文献信息

• [EN] SUBSTITUTED UREA-OCTAHYDROINDOLS AS ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR 1 (MCH1R)<br/>[FR] UREE-OCTAHYDROINDOLES SUBSTITUES UTILISES EN TANT QU'ANTAGONISTES DU RECEPTEUR 1 DE L'HORMONE DE CONCENTRATION DE LA MELANINE (MCH1R)
  申请人：BIOVITRUM AB

  公开号：WO2005051380A1

  公开（公告）日：2005-06-09

  The invention relates to compounds of the general formula (I). (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, and X are as defined in the description, or pharmaceutically acceptable salts, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).

  该发明涉及通式（I）的化合物。其中R1、R2、R3、R4、R5、R6、R7、R8和X如描述中所定义，或药用盐、水合物、几何异构体、拉克酸盐、互变异构体、光学异构体、N-氧化物及其前药形式。这些化合物可用于治疗或预防与MCH1R受体相关的疾病，并用于调节食欲。该发明还涉及该用途以及包含通式（I）化合物的药物配方。
• New compounds
  申请人：Browning Andrew

  公开号：US20050239841A1

  公开（公告）日：2005-10-27

  The invention relates to compounds of the general formula (I) wherein R 0 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , Ar, and X are as defined in the description, or a pharmaceutically acceptable salt, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).

  本发明涉及一般式（I）的化合物，其中R0，R1，R2，R3，R4，R5，R6，R7，R8，R9，Ar和X如描述中所定义，或其药学上可接受的盐，水合物，几何异构体，外消旋体，互变异构体，光学异构体，N-氧化物和前药形式。该化合物可用于治疗或预防与MCH1R受体相关的疾病，并用于调节食欲。本发明还涉及此类用途，以及包含式（I）化合物的制药配方。
• Compounds
  申请人：Browning Andrew

  公开号：US20050192339A1

  公开（公告）日：2005-09-01

  The invention relates to compounds of the general formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and X are as defined in the description, or pharmaceutically acceptable salts, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).

  本发明涉及通式(I)的化合物，其中R1、R2、R3、R4、R5、R6、R7、R8和X如描述中所定义，或其药学上可接受的盐、水合物、几何异构体、外消旋体、互变异构体、光学异构体、N-氧化物和前药形式。这些化合物可用于治疗或预防与MCH1R受体有关的疾病，并用于调节食欲。本发明还涉及这种用途以及包含通式(I)化合物的制药配方。