N-(5-chlorobenzo[b]thiophen-3-ylmethyl)-N-hydroxy-formamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: N-(5-chlorobenzo[b]thiophen-3-ylmethyl)-N-hydroxy-formamide
• 英文别名: N-[(5-chloro-1-benzothiophen-3-yl)methyl]-N-hydroxyformamide
• 化学式: C₁₀H₈ClNO₂S
• 分子量: 241.698
• InChiKey: AZTOCSSWELIPBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  68.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-溴甲基-5-氯苯并噻吩 、 甲酸对硝基苯酯 生成 N-(5-chlorobenzo[b]thiophen-3-ylmethyl)-N-hydroxy-formamide
  参考文献：
  名称：

  Solid-Phase Synthesis of N-Formylhydroxylamines (Reverse/Retro-Hydroxamates)

  摘要：

  [GRAPHICS]N-Formy1hydroxylamines, also known as reverse- or retro-hydroxamates, have become of significant interest in the recent past as inhibitors of metalloenzymes. Although solution-phase synthetic routes to such compounds have been reported, these are often lengthy and involve purification at each stage. Herein, novel three-step solid-phase synthetic approaches are described that enable libraries of such compounds to be produced in a convergent and efficient manner using commercially available starting materials.

  DOI：

  10.1021/ol0513995

文献信息

• Solid-Phase Synthesis of <i>N-</i>Formylhydroxylamines (Reverse/Retro-Hydroxamates)
  作者：Steve Price、Susan E. Osbourn

  DOI：10.1021/ol0513995

  日期：2005.8.1

  [GRAPHICS]N-Formy1hydroxylamines, also known as reverse- or retro-hydroxamates, have become of significant interest in the recent past as inhibitors of metalloenzymes. Although solution-phase synthetic routes to such compounds have been reported, these are often lengthy and involve purification at each stage. Herein, novel three-step solid-phase synthetic approaches are described that enable libraries of such compounds to be produced in a convergent and efficient manner using commercially available starting materials.