| 1380586-96-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• CAS: 1380586-96-8
• 化学式: C₆₄H₁₀₈N₅O₈
• 分子量: 1075.59
• InChiKey: SQIKXIFRBINRLU-GERSPUQRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.52
• 重原子数：
  77.0
• 可旋转键数：
  14.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  118.16
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  、 三氟乙酸 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Cationic Lipids Containing Cyclen and Ammonium Moieties as Gene Delivery Vectors

  摘要：

  In this study, two novel cationic lipids containing protonated cyclen and quaternary ammonium moieties were designed and synthesized as non‐viral gene delivery vectors. The structures of the two lipids differ in their hydrophobic region (cholesterol or diosgenin). Cationic liposomes were easily prepared from the lipids individually or from the mixtures of each cationic lipid and dioleoylphosphatidylethanolamine. Several studies including DLS, gel retardation assay, and ethidium bromide intercalation assay suggest that these amphiphilic molecules are able to bind and compact DNA into nanometer particles which can be used as non‐viral gene delivery agents. Our results from in vitro transfection show that in association with dioleoylphosphatidylethanolamine, two cationic lipids can induce effective gene transfection in human embryonic kidney 293 cells, although the gene transfection efficiencies of two cationic lipids were found to be lower than that of lipofectamine 2000TM. Besides, different cytotoxicity was found for two lipoplexes. This study demonstrates that the title cationic lipids have large potential to be efficient non‐viral gene vectors.

  DOI：

  10.1111/j.1747-0285.2012.01355.x
• 作为产物：
  描述：

  胆固醇 在 sodium carbonate 、 三乙胺 、 potassium iodide 作用下， 以 二氯甲烷 、 氯仿 、 二甲基亚砜 、 乙腈 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Cationic Lipids Containing Cyclen and Ammonium Moieties as Gene Delivery Vectors

  摘要：

  In this study, two novel cationic lipids containing protonated cyclen and quaternary ammonium moieties were designed and synthesized as non‐viral gene delivery vectors. The structures of the two lipids differ in their hydrophobic region (cholesterol or diosgenin). Cationic liposomes were easily prepared from the lipids individually or from the mixtures of each cationic lipid and dioleoylphosphatidylethanolamine. Several studies including DLS, gel retardation assay, and ethidium bromide intercalation assay suggest that these amphiphilic molecules are able to bind and compact DNA into nanometer particles which can be used as non‐viral gene delivery agents. Our results from in vitro transfection show that in association with dioleoylphosphatidylethanolamine, two cationic lipids can induce effective gene transfection in human embryonic kidney 293 cells, although the gene transfection efficiencies of two cationic lipids were found to be lower than that of lipofectamine 2000TM. Besides, different cytotoxicity was found for two lipoplexes. This study demonstrates that the title cationic lipids have large potential to be efficient non‐viral gene vectors.

  DOI：

  10.1111/j.1747-0285.2012.01355.x