ethyl 3-(2-furylthio)propanoate | 127505-59-3

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: ethyl 3-(2-furylthio)propanoate
• 英文别名: ethyl 3-(furylthio)propanoate；ethyl 3-(furan-2-ylsulfanyl)propanoate
• CAS: 127505-59-3
• 化学式: C₉H₁₂O₃S
• 分子量: 200.258
• InChiKey: KNVFUQXGJIIFHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  64.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 3-(2-furylthio)propanoate 生成 3-(2-furylthio)-1-nitropropane
  参考文献：
  名称：

  分子内一氧化氮环化成呋喃的区域和立体选择性

  摘要：

  分子内一氧化氮环加成到官能化呋喃中的过程是完全的区域化学控制，但非对映选择性低。

  DOI：

  10.1016/s0040-4039(01)80569-4
• 作为产物：
  描述：

  3-溴丙酸乙酯 、 lithium 2-furyl thiolate 生成 ethyl 3-(2-furylthio)propanoate
  参考文献：
  名称：

  分子内一氧化氮环化成呋喃的区域和立体选择性

  摘要：

  分子内一氧化氮环加成到官能化呋喃中的过程是完全的区域化学控制，但非对映选择性低。

  DOI：

  10.1016/s0040-4039(01)80569-4

文献信息

• Substituted dibenzoxazepine compounds
  申请人：G. D. Searle & Co.

  公开号：US05378840A1

  公开（公告）日：1995-01-03

  The present invention provides dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

  本发明提供了一种 Formula I 的二苯并噁唑烷化合物：##STR1##，这些化合物可用作治疗疼痛的止痛剂，包括在药物组合物中含有 Formula I 化合物的治疗有效量与药用载体的药物组合物，以及一种消除或减轻动物疼痛的方法，包括向动物施用 Formula I 化合物的治疗有效量。
• Substituted dibenzoxapine compounds, pharmaceutical compositions and
  申请人：G. D. Searle & Co.

  公开号：US05464830A1

  公开（公告）日：1995-11-07

  The present invention provides dibenzoxazepine compounds, of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

  本发明提供了二苯并噁唑化合物，化学式为I：##STR1## 该化合物可用作镇痛剂，用于治疗疼痛，药物组合物包括化合物I的治疗有效量与药物可接受载体的组合，以及一种用于消除或缓解动物疼痛的方法，包括向动物施用化合物I的治疗有效量。
• Substituted dibenzoxazepine compounds and methods for treating
  申请人：G.D. Searle & Co.

  公开号：US05576315A1

  公开（公告）日：1996-11-19

  The present invention provides dibenzoxazepine compounds of Formula I: ##STR1## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

  本发明提供了一种二苯并噁唑化合物，其化学式为I：##STR1## 该化合物可用作镇痛剂治疗疼痛，药物组合物包括一种化合物I的治疗有效量和药学上可接受的载体，以及一种用于消除或缓解动物疼痛的方法，包括向动物投与化合物I的治疗有效量。
• Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
  申请人：G.D. Searle & Co.

  公开号：EP0512400A1

  公开（公告）日：1992-11-11

  The present invention provides dibenzoxazepine compounds of Formula I: which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.

  本发明提供了式 I 的二苯并氧氮杂卓化合物： 可用作治疗疼痛的镇痛剂；包含治疗有效量的式 I 化合物与药学上可接受的载体的药物组合物；以及消除或改善动物疼痛的方法，该方法包括对动物施用治疗有效量的式 I 化合物。
• Regio- and stereocontrol in the intramolecular nitrile oxide cycloaddition to 2-furylthiol- and 2-furylmethanethiol derivatives.
  作者：Rita Annunziata、Mauro Cinquini、Franco Cozzi、Laura Raimondi、Giulia Licini

  DOI：10.1016/s0040-4020(01)80910-8

  日期：——

  A series of 2-furyl and 2-furylmethyl substituted nitrosulphides with a proper chain length were prepared and showed to undergo a totally regiocontrolled intramolecular furan-nitrile oxide cycloaddition to give cis-fused products in high yield. Insertion of a stereocenter on the cycloaddends did not allow satisfactory control of the absolute stereochemistry of the reaction. Enantiomerically enriched products (e.e. less-than-or-equal-to 95%) were obtained by a kinetic resolution process involving oxidation of the sulphide cycloadducts to the corresponding sulphoxides.