6-methoxytetralone

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 6-methoxytetralone
• 英文别名: 6-Methoxy-2-methyl-1-nitroso-1,2,3,4-tetrahydronaphthalene；6-methoxy-2-methyl-1-nitroso-1,2,3,4-tetrahydronaphthalene
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.257
• InChiKey: ARMSESWJDHYXMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-methoxytetralone 在 硫酸 、 1,3-bis[3,5-bis(trifluoromethyl)phenyl]urea 、 sodium nitrite 作用下， 以 乙醚 、 水 为溶剂， 反应 24.0h， 生成 1-(6-methoxy-2-methyl-3,4-dihydronaphthalen-1-yl)indoline
  参考文献：
  名称：

  Urea Activation of Nitrimines: A Mild, Metal-Free Approach to Sterically Hindered Enamines

  摘要：

  Nitrimines have been identified as impressive starting points for the syntheses of otherwise inaccessible, sterically encumbered enamines. The activation of nitrimines with urea catalysts for reaction with a variety of amines enables the formation of highly substituted enamines in high yield. The reactions benefit from mild, metal-free conditions, high functional group tolerance, and straightforward scale up.

  DOI：

  10.1021/ol402310b
• 作为产物：
  描述：

  6-甲氧基-2-甲基-3,4-二氢-1(2H)-萘酮 在 盐酸羟胺 、 sodium acetate trihydrate 作用下， 以 甲醇 、 水 为溶剂， 反应 12.0h， 以93%的产率得到6-methoxytetralone
  参考文献：
  名称：

  Urea Activation of Nitrimines: A Mild, Metal-Free Approach to Sterically Hindered Enamines

  摘要：

  Nitrimines have been identified as impressive starting points for the syntheses of otherwise inaccessible, sterically encumbered enamines. The activation of nitrimines with urea catalysts for reaction with a variety of amines enables the formation of highly substituted enamines in high yield. The reactions benefit from mild, metal-free conditions, high functional group tolerance, and straightforward scale up.

  DOI：

  10.1021/ol402310b

文献信息

• Urea Activation of Nitrimines: A Mild, Metal-Free Approach to Sterically Hindered Enamines
  作者：David M. Nickerson、Veronica V. Angeles、Anita E. Mattson

  DOI：10.1021/ol402310b

  日期：2013.10.4

  Nitrimines have been identified as impressive starting points for the syntheses of otherwise inaccessible, sterically encumbered enamines. The activation of nitrimines with urea catalysts for reaction with a variety of amines enables the formation of highly substituted enamines in high yield. The reactions benefit from mild, metal-free conditions, high functional group tolerance, and straightforward scale up.