(Z,4R,8S)-4-[tert-butyl(diphenyl)silyl]oxy-8-[(4-methoxyphenyl)methoxy]non-2-enal | 1228301-00-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z,4R,8S)-4-[tert-butyl(diphenyl)silyl]oxy-8-[(4-methoxyphenyl)methoxy]non-2-enal
• CAS: 1228301-00-5
• 化学式: C₃₃H₄₂O₄Si
• 分子量: 530.78
• InChiKey: ZNCNVMZOZJAPNH-MHYNGQFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.47
• 重原子数：
  38
• 可旋转键数：
  15
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Z,4R,8S)-4-[tert-butyl(diphenyl)silyl]oxy-8-[(4-methoxyphenyl)methoxy]non-2-enal 、 叔丁基二甲基(2-丙炔氧基)硅烷 在 (R,R)-(-)-2,6-bis[2-(hydroxyldiphenylmethyl)-1-pyrrolidinyl-methyl]-4-methylphenole 、 Dimethylzinc 作用下， 生成 (Z,4S,7R,11S)-1-[tert-butyl(dimethyl)silyl]oxy-7-[tert-butyl(diphenyl)silyl]oxy-11-[(4-methoxyphenyl)methoxy]dodec-5-en-2-yn-4-ol 、
  参考文献：
  名称：

  Asymmetric synthesis of (+)-chloriolide

  摘要：

  An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macrolactonization has been successfully employed to achieve the target molecule. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.028
• 作为产物：
  描述：

  (Z,4R,8S)-4-[tert-butyl(diphenyl)silyl]oxy-8-[(4-methoxyphenyl)methoxy]non-2-en-1-ol 在 戴斯-马丁氧化剂 作用下， 以93%的产率得到(Z,4R,8S)-4-[tert-butyl(diphenyl)silyl]oxy-8-[(4-methoxyphenyl)methoxy]non-2-enal
  参考文献：
  名称：

  Asymmetric synthesis of (+)-chloriolide

  摘要：

  An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macrolactonization has been successfully employed to achieve the target molecule. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.03.028

文献信息

• Asymmetric synthesis of (+)-chloriolide
  作者：Tapas Das、Nandan Jana、Samik Nanda

  DOI：10.1016/j.tetlet.2010.03.028

  日期：2010.5

  An asymmetric synthesis of 12-membered ring macrolide, chloriolide has been accomplished by adopting a linear strategy. Lipase-catalyzed enzymatic kinetic resolution (EKR), asymmetric alkynylation using Trost pro-phenol catalyst followed by Yamaguchi macrolactonization has been successfully employed to achieve the target molecule. (C) 2010 Elsevier Ltd. All rights reserved.