1,4-diisocyanatocubane | 116635-16-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,4-diisocyanatocubane
• CAS: 116635-16-6
• 化学式: C₁₀H₆N₂O₂
• 分子量: 186.17
• InChiKey: FTTKSBDVBMKJRQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  58.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,4-diisocyanatocubane 在 二甲基二环氧乙烷 作用下， 以 水 、 丙酮 为溶剂， 反应 1.0h， 以85%的产率得到1,4-dinitrocubane
  参考文献：
  名称：

  Conversion of isocyanates to nitro compounds with dimethyldioxirane in wet acetone

  摘要：

  DOI：

  10.1021/jo00257a030
• 作为产物：
  描述：

  1,4-cubanedicarboxylic acid dichloride 在 叠氮基三甲基硅烷 作用下， 以 四氯化碳 、 氯仿 为溶剂， 反应 2.0h， 生成 1,4-diisocyanatocubane
  参考文献：
  名称：

  Conversion of isocyanates to nitro compounds with dimethyldioxirane in wet acetone

  摘要：

  DOI：

  10.1021/jo00257a030

文献信息

• EATON, PHILIP E.;WICKS, GENE E., J. ORG. CHEM., 53,(1988) N 22, C. 5353-5355
  作者：EATON, PHILIP E.、WICKS, GENE E.

  DOI：——

  日期：——
• Polymers for implantable devices exhibiting shape-memory effects
  申请人：Stankus John

  公开号：US20090035350A1

  公开（公告）日：2009-02-05

  The present invention is directed to polymeric compositions comprising a biodegradable copolymer that possesses shape-memory properties and implantable devices (e.g., drug-delivery stents) formed of materials (e.g., a coating) containing such compositions. The polymeric compositions can also contain at least one non-fouling moiety, at least additional biocompatible polymer, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric compositions are formulated to possess good mechanical, physical and biological properties. Moreover, implantable devices formed of materials comprising such compositions can be delivered to the treatment site in a conveniently compressed size and then can expand to dimensions appropriate for their medical functions.
• US9066992B2
  申请人：——

  公开号：US9066992B2

  公开（公告）日：2015-06-30
• [EN] POLYMERS FOR IMPLANTABLE DEVICES EXHIBITING SHAPE-MEMORY EFFECTS<br/>[FR] POLYMÈRES POUR DISPOSITIFS IMPLANTABLES À MÉMOIRE DE FORME
  申请人：ABBOTT CARDIOVASCULAR SYSTEMS

  公开号：WO2009020797A2

  公开（公告）日：2009-02-12

  The present invention is directed to polymeric compositions comprising a biodegradable copolymer that possesses shape-memory properties and implantable devices (e.g., drug-delivery stents) formed of materials (e.g., a coating) containing such compositions. The polymeric compositions can also contain at least one non-fouling moiety, at least additional biocompatible polymer, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric compositions are formulated to possess good mechanical, physical and biological properties. Moreover, implantable devices formed of materials comprising such compositions can be delivered to the treatment site in a conveniently compressed size and then can expand to dimensions appropriate for their medical functions.
• Conversion of isocyanates to nitro compounds with dimethyldioxirane in wet acetone
  作者：Philip E. Eaton、Gene E. Wicks

  DOI：10.1021/jo00257a030

  日期：1988.10