2-异丙基四氢-2H-吡喃-4-羧酸 | 77554-89-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 中文名称: 2-异丙基四氢-2H-吡喃-4-羧酸
• 英文名称: 2-isopropyltetrahydropyran-4-carboxylic acid
• 英文别名: 2-Isopropyl-tetrahydropyran-4-carbonsaeure；2-Isopropyltetrahydro-2H-pyran-4-carboxylic acid；2-propan-2-yloxane-4-carboxylic acid
• CAS: 77554-89-3
• 化学式: C₉H₁₆O₃
• 分子量: 172.224
• InChiKey: OANZNLSVCHRGLN-UHFFFAOYSA-N

物化性质

• 沸点：
  285.7±33.0 °C(Predicted)
• 密度：
  1.064±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  2-异丙基四氢-2H-吡喃-4-羧酸 、 氯化亚砜 以77%的产率得到
  参考文献：
  名称：

  KUROYAN R. A.; MARKOSYAN A. I.; VARTANYAN S. A., AJKAKAN KIMIAKAN AMSAGIR, ARM. XIM. ZH., 1981, 34, HO 1, 52-55

  摘要：

  DOI：

文献信息

• [EN] PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES<br/>[FR] PRÉPARATION ET UTILISATIONS DE DÉRIVÉS DE PYRIMIDINONE
  申请人：CANCER RESEARCH TECH LTD

  公开号：WO2018055402A1

  公开（公告）日：2018-03-29

  The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: (Formula (I)) wherein X, R1, R2, and n are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.

  本发明涉及式(I)的化合物，以及其盐和溶剂合物，其作为细胞分裂周期7（Cdc7）激酶酶活性的抑制剂：（式(I)）其中X，R1，R2和n如本文所定义。本发明还涉及制备这些化合物的方法，包括它们的药物组合物，以及它们在治疗增殖性疾病（如癌症）以及其他涉及Cdc7激酶活性的疾病或病况中的用途。
• [EN] SUBSTITUTED PYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS<br/>[FR] PYRAZOLES SUBSTITUÉS SERVANT DE BLOQUEURS DE CANAL CALCIQUE DE TYPE N
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2014028803A1

  公开（公告）日：2014-02-20

  The present invention relates to compounds of Formula (I), wherein X1, X2, X3, X4, R1, R2, R3, and Q are as defined herein, useful as N-type calcium channel blockers.

  本发明涉及式(I)化合物，其中X1、X2、X3、X4、R1、R2、R3和Q如本文所述定义，用作N型钙通道阻断剂。
• SUBSTITUTED PYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS
  申请人：Janssen Pharmaceutica NV

  公开号：US20140163031A1

  公开（公告）日：2014-06-12

  The present invention relates to compounds of Formula (I), wherein X 1 , X 2 , X 3 , X 4 , R 1 , R 2 , R 3 , and Q are as defined herein, useful as N-type calcium channel blockers.

  本发明涉及式(I)的化合物，其中X1、X2、X3、X4、R1、R2、R3和Q的定义如本文所述，作为N型钙通道阻滞剂有用。
• Preparation and uses of pyrimidinone derivatives
  申请人：Cancer Research Technology Limited

  公开号：US10919896B2

  公开（公告）日：2021-02-16

  The present invention relates to compounds of formula (I), and salts and solvates thereof, that function as inhibitors of cell division cycle 7 (Cdc7) kinase enzyme activity: wherein X, R1, R2, and n are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which Cdc7 kinase activity is implicated.

  本发明涉及作为细胞分裂周期 7（Cdc7）激酶酶活性抑制剂的式 (I) 化合物及其盐和溶液： 其中 X、R1、R2 和 n 各自如本文所定义。本发明还涉及这些化合物的制备工艺、包含这些化合物的药物组合物，以及它们在治疗增殖性疾病（如癌症）和其他涉及 Cdc7 激酶活性的疾病或病症中的用途。
• PREPARATION AND USES OF PYRIMIDINONE DERIVATIVES
  申请人：Cancer Research Technology Limited

  公开号：EP3515903A1

  公开（公告）日：2019-07-31