N-butyl-N'-p-toluoyl-guanidine | 88858-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-butyl-N'-p-toluoyl-guanidine
• 英文别名: N-Butyl-N'-p-toluoyl-guanidin；N-(4-methylbenzoyl)-N'-butylguanidine；N-(N'-butylcarbamimidoyl)-4-methylbenzamide
• CAS: 88858-22-4
• 化学式: C₁₃H₁₉N₃O
• 分子量: 233.313
• InChiKey: ALSYKIYWLYFZIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氯甲苯 在 乙醇 、 potassium carbonate 作用下， 生成 N-butyl-N'-p-toluoyl-guanidine
  参考文献：
  名称：

  Risk-resistance adaptation model for caregivers and their children with sickle cell syndromes

  摘要：

  This investigation examined the risk-resistance adaptation model for children with sickle cell disease and their primary caregivers. Participants were 55 children, ranging in age from 5 to 16 years with a mean age of 9 years 2 months, diagnosed with sickle cell disease and their primary caregivers, recruited from a university medical center Measures included adjustment (i.e. primary caregiver and child adjustment), risk factors (i.e. disease and disability, functional independence, and psychosocial stressors), resistance factors (i.e, intrapersonal health locus of control, social-ecological), and stress processing (coping). Primary caregivers' adjustment was associated with developmental coping, R-change(2) = .08, and child adaptation was associated with an internal health locus of control, R-change(2) = .22. An indirect effect of primary caregivers' coping on child adjustment was found through influence on primary caregivers' adjustment, R-change(2) = .11. The findings support research among other chronically ill populations that suggests an association between coping and disease adjustment. The results were interpreted to support the use of theoretically driven models in predicting the adaptation of children with chronic illness and adjustment in their caregivers.

  DOI：

  10.1007/bf02895780

文献信息

• Solution-Phase, parallel synthesis and pharmacological evaluation of acylguanidine derivatives as potential sodium channel blockers
  作者：Seetharamaiyer Padmanabhan、Ruth C Lavin、Paresh M Thakker、Jinqing Guo、Lu Zhang、Deke Moore、Michael E Perlman、Cassandra Kirk、Deborah Daly、Kathy J Burke-Howie、Teresa Wolcott、Suchitra Chari、David Berlove、James B Fischer、William F Holt、Graham J Durant、Robert N McBurney

  DOI：10.1016/s0960-894x(01)00644-8

  日期：2001.12

  Solution-phase synthesis of various acylguanidine derivatives and the evaluation of a small library of compounds as potential sodium channel blockers are described.

  描述了各种酰基胍衍生物的溶液相合成和作为潜在的钠通道阻滞剂的化合物小文库的评估。
• A GENERAL PROCEDURE FOR THE SYNTHESIS OF ACYLGUANIDINES DERIVED FROM ALIPHATIC AND AROMATIC AMINES
  作者：Seetharamaiyer Padmanabhan、Ruth C. Lavin、Paresh M. Thakkar、Graham J. Durant

  DOI：10.1081/scc-100105128

  日期：2001.1

  Condensation of aliphatic and aromatic amines with 1-aroyl- S-methylisothiourea in the presence of triethylamine affords acylguanidines in moderate to good yields. An improved procedure for the generation of 1-aroyl-S-methylisothiourea derivatives is described.

  在三乙胺的存在下，脂肪族和芳香族胺与 1-芳酰基-S-甲基异硫脲的缩合得到中等至良好产率的酰基胍。描述了一种用于生成 1-芳酰基-S-甲基异硫脲衍生物的改进程序。
• Pharmaceutically active compounds and methods of use
  申请人：Durant J. Graham

  公开号：US20060270741A1

  公开（公告）日：2006-11-30

  The present invention relates to pharmaceutically acceptable compounds, including acylguanidine compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or prophylaxis of neurological injury and neurodegenerative disorders.

  本发明涉及药学上可接受的化合物，包括酰基胍化合物，以及利用或包含一种或多种这样的化合物的治疗方法和制药组合物。本发明的化合物特别适用于治疗或预防神经损伤和神经退行性疾病。
• US7041702B1
  申请人：——

  公开号：US7041702B1

  公开（公告）日：2006-05-09
• Risk-resistance adaptation model for caregivers and their children with sickle cell syndromes
  作者：Ronald T. Brown、Richard Lambert、Danielle Devine、Kevin Baldwin、Robert Casey、Karla Doepke、Carolyn E. Ievers、Lewis Hsu、Iris Buchanan、James Eckman

  DOI：10.1007/bf02895780

  日期：2000.6

  This investigation examined the risk-resistance adaptation model for children with sickle cell disease and their primary caregivers. Participants were 55 children, ranging in age from 5 to 16 years with a mean age of 9 years 2 months, diagnosed with sickle cell disease and their primary caregivers, recruited from a university medical center Measures included adjustment (i.e. primary caregiver and child adjustment), risk factors (i.e. disease and disability, functional independence, and psychosocial stressors), resistance factors (i.e, intrapersonal health locus of control, social-ecological), and stress processing (coping). Primary caregivers' adjustment was associated with developmental coping, R-change(2) = .08, and child adaptation was associated with an internal health locus of control, R-change(2) = .22. An indirect effect of primary caregivers' coping on child adjustment was found through influence on primary caregivers' adjustment, R-change(2) = .11. The findings support research among other chronically ill populations that suggests an association between coping and disease adjustment. The results were interpreted to support the use of theoretically driven models in predicting the adaptation of children with chronic illness and adjustment in their caregivers.