6-chloro-1-naphthaldehyde | 116632-02-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-chloro-1-naphthaldehyde
• 英文别名: 6-Chlor-[1]naphthaldehyd；6-Chloronaphthalene-1-carbaldehyde
• CAS: 116632-02-1
• 化学式: C₁₁H₇ClO
• 分子量: 190.629
• InChiKey: RTJQARCLKRKHOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  6-chloro-1-naphthaldehyde 在 2-氨基苯磺酸 、 [双(三氟乙酰氧基)碘]苯 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 作用下， 以 1,2-二氯乙烷 为溶剂， 以81%的产率得到6-chloro-8-hydroxy-1-naphthaldehyde
  参考文献：
  名称：

  Palladium-Catalyzed Regiospecific peri- and ortho-C–H Oxygenations of Polyaromatic Rings Mediated by Tunable Directing Groups

  摘要：

  DOI：

  10.1021/acs.orglett.0c03701
• 作为产物：
  描述：

  6-氯萘-1-羧酸 在 氯化亚砜 作用下， 生成 6-chloro-1-naphthaldehyde
  参考文献：
  名称：

  取代的α-二烷基氨基烷基-1-萘甲醇; 格氏试剂合成一些丙醇胺。

  摘要：

  DOI：

  10.1021/jo01173a003

文献信息

• Benzamidine derivatives
  申请人：SANKYO COMPANY, LIMITED

  公开号：US20040248981A1

  公开（公告）日：2004-12-09

  Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: 1 wherein R 1 represents a hydrogen atom, a halogen atom, an alkyl group or a hydroxyl group; R 2 represents a hydrogen atom, a halogen atom or an alkyl group, R 3 represents a hydrogen atom, an optionally substituted alkyl group, an aralkyl group, an optionally substituted alkanoyl group or an optionally substituted alkylsulfonyl group, R 4 and R 5 are the same as or different from each other and each represent a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkoxy group, a carboxyl-group, an alkoxycarbonyl group or an optionally substituted carbamoyl group, and R 6 represents a substituted pyrrolidine group or substituted piperidine group.

  公式（I）中的苯甲酰胺衍生物或其药学上可接受的盐表现出优异的抑制因子Xa的活性，可用于治疗或预防血液凝固障碍：其中R1代表氢原子，卤原子，烷基或羟基；R2代表氢原子，卤原子或烷基，R3代表氢原子，可选取代的烷基，芳基烷基，可选取代的烷酰基或可选取代的烷基磺酰基，R4和R5相同或不同，每个代表氢原子，卤原子，可选取代的烷基，烷氧基，羧基，烷氧羰基或可选取代的氨基甲酰基，而R6代表取代的吡咯烷基或取代的哌嗪烷基。
• Process for producing cyclic thioether and synthetic intermediate thereof
  申请人：Tomori Hiroshi

  公开号：US20050165037A1

  公开（公告）日：2005-07-28

  A process for producing cyclic thioether compounds and their synthetic intermediates. The process produces a compound represented by formula (5): wherein G 1 is an alkylene group, R 1 is a thiol protecting group, R 2 is hydrogen or an amino protecting group, and Ar is an aryl group or a 5- to 7-membered heteroaryl group.

  一种生产环硫醚化合物及其合成中间体的方法。该方法产生一个由公式（5）表示的化合物：其中G1是烷基，R1是硫醇保护基，R2是氢或氨基保护基，Ar是芳基或5-至7-成员杂芳基。
• ISOXAZOLE DERIVATIVES
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0885891A1

  公开（公告）日：1998-12-23

  The isoxazole derivatives having the following general formula: [wherein R1 represents an optionally substituted aryl group or aromatic heterocyclic group; R2 represents a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, a cycloalkenyl group, an alkoxy group, a cyano group, a carboxyl group, an alkanoyl group, an alkoxycarbonyl group or an optionally substituted carbamoyl group; R3 represents an optionally substituted amino group or a saturated heterocyclic group; X represents an oxygen atom or a sulfur atom; n is an integer of from 2 to 6] has an excellent monoamine oxidase inhibitory activity, and is useful as a therapeutic agent or a preventive agent against nervous diseases such as depression.

  具有以下通式的异噁唑衍生物： [其中 R1 代表任选取代的芳基或芳香杂环基团；R2 代表氢原子、卤素原子、任选取代的烷基、烯基、炔基、环烷基、环烯基、烷氧基、氰基、羧基、烷酰基、烷氧羰基或任选取代的氨基甲酰基；R3 代表任选取代的氨基或饱和杂环基团；X 代表氧原子或硫原子；n 为 2 至 6 的整数]具有极佳的单胺氧化酶抑制活性，可用作治疗剂或预防剂，防治抑郁症等神经疾病。
• PROCESS FOR PRODUCING CYCLIC THIOETHER AND SYNTHETIC INTERMEDIATE THEREOF
  申请人：Sankyo Company, Limited

  公开号：EP1533314A1

  公开（公告）日：2005-05-25

  The present invention provides a process for producing cyclic thioether compounds and their synthetic intermediates. [Means for Solution] A compound represented by general formula (5): [wherein G1: alkylene, R1: a thiol protecting group, R2: hydrogen or an amino protecting group, and Ar: aryl group and so forth].

  本发明提供了一种生产环状硫醚化合物及其合成中间体的工艺。 [解决方法］ 由通式（5）代表的化合物： [其中 G1：亚烷基；R1：硫醇保护基；R2：氢或氨基保护基；Ar：芳基等]。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE SULFOXIDE
  申请人：Sankyo Company, Limited

  公开号：EP1557420A1

  公开（公告）日：2005-07-27

  [Object] The present invention provides a process for preparing optically active cyclic sulfoxides. [Means for solution] A process for preparing an optically active cyclic sulfoxide, which is characterized by reacting a cyclic thioether with cumene hydroperoxide or isopropylcumyl hydroperoxide in the presence of alcohol, water or a mixture of water and alcohol and in the presence of a complex of an optically active tartaric acid diester and a titanium (IV) alkoxide in an inert solvent.

  目的 本发明提供了一种制备光学活性环状氧化硫的工艺。 [解决方法］ 一种制备光学活性环状氧化硫的工艺，其特征在于：在醇、水或水和醇的混合物存在下，以及在光学活性酒石酸二酯和钛(IV)烷氧化物的络合物存在下，在惰性溶剂中，使环状硫醚与过氧化氢己烯或过氧化氢异丙苯反应。