1-methyl-3-propyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-d]pyrimidin-5,7-dione | 848126-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 1-methyl-3-propyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-d]pyrimidin-5,7-dione
• 英文别名: 1-Methyl-3-propyl-1,4-dihydro-pyrazolo[4,3-d]pyrimidine-5,7-dione；1-methyl-3-propyl-4H-pyrazolo[4,3-d]pyrimidine-5,7-dione
• CAS: 848126-89-6
• 化学式: C₉H₁₂N₄O₂
• 分子量: 208.22
• InChiKey: BTVNETPEFLYJKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-methyl-3-propyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-d]pyrimidin-5,7-dione 在 N,N-二甲基甲酰胺 三氯氧磷 作用下， 反应 16.0h， 生成 5,7-dichloro-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidine
  参考文献：
  名称：

  Novel compounds useful for the treatment of degenerative & inflammatory diseases

  摘要：

  本发明涉及一种抑制PDE1A的化合物，PDE1A是参与调节软骨降解、关节退化以及涉及此类降解和/或炎症的疾病的磷酸二酯酶。

  公开号：

  US20080242661A1
• 作为产物：
  描述：

  4-氨基-1-甲基-3-正丙基-1H-吡唑-5-羧酰胺 在 溶剂黄146 作用下， 以 苯 为溶剂， 反应 4.0h， 生成 1-methyl-3-propyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-d]pyrimidin-5,7-dione
  参考文献：
  名称：

  Reddy, N. Ram; Reddy, P. Pratap, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004, vol. 43, # 10, p. 2165 - 2169

  摘要：

  DOI：

文献信息

• [EN] NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES<br/>[FR] NOUVEAUX COMPOSÉS UTILES POUR LE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES
  申请人：GALAPAGOS NV

  公开号：WO2009071707A1

  公开（公告）日：2009-06-11

  The present invention relates to compounds that are inhibitors of PDElA, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation, and particularly, to a compound according to formula (I), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof or isotopic variants thereof, stereoisomers or tautomers thereof. The invention extends to compositions, including pharmaceutical compositions, and corresponding uses thereof, and methods of prophylaxis and treatment involving the same.

  本发明涉及一类抑制PDElA的化合物，PDElA是一种参与软骨降解、关节退化以及涉及该降解和/或炎症的疾病调控的磷酸二酯酶，特别是一种符合以下式（I）的化合物，或其药学上可接受的盐、水合物、溶剂合物或前药，或其同位素变体、立体异构体或互变异构体。该发明涉及包括药物组合物在内的组合物，以及其相应的用途，涉及预防和治疗的方法。
• [EN] PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES<br/>[FR] NOUVEAUX COMPOSÉS UTILES POUR LE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES
  申请人：GALAPAGOS NV

  公开号：WO2009071706A1

  公开（公告）日：2009-06-11

  The present invention relates to compounds that are inhibitors of PDElA, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation, and particularly, to a compound according to formula I: or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof or isotopic variants thereof, stereoisomers or tautomers thereof. The invention extends to compositions, including pharmaceutical compositions, and corresponding uses thereof, and methods of prophylaxis and treatment involving the same.

  本发明涉及一种抑制PDElA的化合物，PDElA是参与调节软骨降解、关节退化以及涉及此类降解和/或炎症的疾病的磷酸二酯酶，特别是根据式I的化合物：或其药学上可接受的盐、水合物、溶剂合物或前药，或其同位素变体、立体异构体或互变异构体。本发明还涉及包括药物组合物在内的组合物，以及其相应的用途和涉及相同的预防和治疗方法。
• [EN] 5,7-DIAMINOPYRAZOLO`4,3-D!PYRIMIDINES USEFUL IN THE TREATMENT OF HYPERTENSION<br/>[FR] 5,7-DIAMINOPYRAZOLO`4,3-D!PYRIMIDINES UTILES POUR LE TRAITEMENT DE L'HYPERTENSION
  申请人：PFIZER LTD

  公开号：WO2004096810A1

  公开（公告）日：2004-11-11

  This invention relates to compounds of formula (I).

  这项发明涉及到式(I)的化合物。
• [EN] NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES<br/>[FR] NOUVEAUX COMPOSÉS UTILES DANS LE TRAITEMENT DE MALADIES DÉGÉNÉRATIVES ET INFLAMMATOIRES
  申请人：GALAPAGOS NV

  公开号：WO2008071650A2

  公开（公告）日：2008-06-19

  [EN] The present invention relates to compounds that are inhibitors of PDElA, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation.
  [FR] La présente invention concerne des composés qui sont des inhibiteurs de la PDEIA, une phosphodiestérase qui est impliquée dans la modulation de la dégradation du cartilage, la dégénérescence des articulations et des maladies comprenant une telle dégradation et/ou inflammation.
• [EN] ANTIVIRAL PYRIMIDINES<br/>[FR] PYRIMIDINES ANTIVIRALES
  申请人：PROGENICS PHARM INC

  公开号：WO2010118367A2

  公开（公告）日：2010-10-14

  Disclosed herein are novel compounds comprising substituted pyrimidines, pyrazolopyrimtdines, and imidazolopyrimidines, the syntheses thereof, and compositions thereof, including pharmaceutical compositions, comprising the novel pyrimidines, pyrazolopyrimtdines, imidazolpyrimidines and related compounds. Such compounds function to inhibit entry of viruses of the Flaviviridae family, including Hepatitis C virus (HCV), into cells that are susceptible to virus infection. These compounds are useful for the treatment, therapy and/or prophylaxis of viral diseases and infection, including HCV infection.