2,2-dimethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3,7-dicarboxylic acid | 30757-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,2-dimethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3,7-dicarboxylic acid
• 英文别名: 2,2-dimethyl-5-oxo-3H-[1,3]thiazolo[3,2-a]pyridine-3,7-dicarboxylic acid
• CAS: 30757-79-0
• 化学式: C₁₁H₁₁NO₅S
• 分子量: 269.278
• InChiKey: RGSJYLLBPWWCNY-UHFFFAOYSA-N

物化性质

• 沸点：
  533.0±50.0 °C(Predicted)
• 密度：
  1.61±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,2-dimethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3,7-dicarboxylic acid 在 溴 作用下， 以 氯仿 为溶剂， 生成 6,8-dibromo-2,2-dimethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3,7-dicarboxylic acid
  参考文献：
  名称：

  合成并合成新的噻唑洛[3,2-a]-吡啶酮

  摘要：

  描述了通过α-氨基-β-巯基羧酸与柠檬酸反应合成2，3-二氢噻唑并[3，2-a]吡啶酮-（5）-3,7-二羧酸和-3-羧酸。化合物的结构由其分解，光谱行为和其他性质证实。

  DOI：

  10.1016/s0040-4020(01)97756-7
• 作为产物：
  描述：

  DL-青霉胺 、 柠檬酸 生成 2,2-dimethyl-5-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyridine-3,7-dicarboxylic acid
  参考文献：
  名称：

  合成并合成新的噻唑洛[3,2-a]-吡啶酮

  摘要：

  描述了通过α-氨基-β-巯基羧酸与柠檬酸反应合成2，3-二氢噻唑并[3，2-a]吡啶酮-（5）-3,7-二羧酸和-3-羧酸。化合物的结构由其分解，光谱行为和其他性质证实。

  DOI：

  10.1016/s0040-4020(01)97756-7

文献信息

• Luminescent compositions and applications thereof
  申请人：THE PENN STATE RESEARCH FOUNDATION

  公开号：US10648917B2

  公开（公告）日：2020-05-12

  In one aspect, methods of sensing are described herein. In some embodiments, a method of sensing includes disposing a fluorophore in a biological environment, wherein the fluorophore includes a dioxo-pyridine ring (DPR) or a thiazolopyridine acid (TPA). The method further includes exposing the biological environment to electromagnetic radiation having a wavelength corresponding to an excitation wavelength of the fluorophore, detecting light emitted by the fluorophore, and correlating the light emitted by the fluorophore to a presence or absence of an analyte within the biological environment in an amount above a minimum detection threshold. The presence of the analyte can increase or decrease the amount of light emitted by the fluorophore. The presence of the analyte may also shift the peak emission wavelength or alter the fluorescence lifetime of the fluorophore. The analyte, in some embodiments, includes hydrogen ions, halide ions, and/or halogens.

  在一个方面，本文描述了传感方法。在一些实施例中，传感方法包括在生物环境中放置荧光团，其中荧光团包括二氧吡啶环（DPR）或噻唑吡啶酸（TPA）。该方法还包括将生物环境暴露于电磁辐射中，电磁辐射的波长与荧光团的激发波长相对应，检测荧光团发出的光，并将荧光团发出的光与生物环境中分析物的存在或不存在相关联，分析物的量超过最小检测阈值。分析物的存在可增加或减少荧光团发出的光量。被分析物的存在还可能移动峰值发射波长或改变荧光团的荧光寿命。在某些实施方案中，分析物包括氢离子、卤化物离子和/或卤素。
• Luminescent Compositions And Applications Thereof
  申请人：THE PENN STATE RESEARCH FOUNDATON

  公开号：US20180088053A1

  公开（公告）日：2018-03-29

  In one aspect, methods of sensing are described herein. In some embodiments, a method of sensing comprises disposing a fluorophore in a biological environment, wherein the fluorophore comprises a dioxo-pyridine ring (DPR) or a thiazolopyridine acid (TPA). The method further comprises exposing the biological environment to electromagnetic radiation having a wavelength corresponding to an excitation wavelength of the fluorophore, detecting light emitted by the fluorophore, and correlating the light emitted by the fluorophore to a presence or absence of an analyte within the biological environment in an amount above a minimum detection threshold. The presence of the analyte can increase or decrease the amount of light emitted by the fluorophore. The presence of the analyte may also shift the peak emission wavelength or alter the fluorescence lifetime of the fluorophore. The analyte, in some embodiments, comprises hydrogen ions, halide ions, and/or halogens.
• [EN] LUMINESCENT COMPOSITIONS AND APPLICATIONS THEREOF<br/>[FR] COMPOSITIONS LUMINESCENTES ET LEURS APPLICATIONS
  申请人：PENN STATE RES FOUND

  公开号：WO2016164437A1

  公开（公告）日：2016-10-13

  In one aspect, methods of sensing are described herein. In some embodiments, a method of sensing comprises disposing a fluorophore in a biological environment, wherein the fluorophore comprises a dioxo-pyridine ring (DPR) or a thiazolopyridine acid (TPA). The method further comprises exposing the biological environment to electromagnetic radiation having a wavelength corresponding to an excitation wavelength of the fluorophore, detecting light emitted by the fluorophore, and correlating the light emitted by the fluorophore to a presence or absence of an analyte within the biological environment in an amount above a minimum detection threshold. The presence of the analyte can increase or decrease the amount of light emitted by the fluorophore. The presence of the analyte may also shift the peak emission wavelength or alter the fluorescence lifetime of the fluorophore. The analyte, in some embodiments, comprises hydrogen ions, halide ions, and/or halogens.