Salicylaldehyd-selenosemicarbazon | 17222-65-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Salicylaldehyd-selenosemicarbazon
• 英文别名: N'-[(2-hydroxyphenyl)methylideneamino]carbamimidoselenoic acid
• CAS: 17222-65-0
• 化学式: C₈H₉N₃OSe
• 分子量: 242.139
• InChiKey: HHTISYBTBPNJNJ-UHFFFAOYSA-N

物化性质

• 沸点：
  391.9±44.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.47
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  70.64
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  trans-bis(triphenylphosphine)palladium dichloride 、 Salicylaldehyd-selenosemicarbazon 在 Et₃N 作用下， 以 甲苯 为溶剂， 以63%的产率得到
  参考文献：
  名称：

  环己酮硒亚氨基甲酰胺：方便的原料，用于制备官能化硒亚氨基甲酮及其Pt和Pd配合物

  摘要：

  在环己酮存在下，水合肼与KSeCN在酸性乙醇水溶液中反应，可得到高产率的环己酮硒亚氨基卡巴carb。通过用醛处理，将环己酮硒亚氨基甲酰胺转化成各种官能化的硒亚氨基甲唑酮。制备了水杨醛硒亚氨基卡巴zone及其1,2-萘基衍生物，并与某些Pd（II）和Pt（II）膦配合物反应，得到[M（L Se）（P）]类型的化合物，其中M = Pt和Pd ，L Se是双去质子化的亚硒酰胺，P是单齿膦。在这些络合物中，配体充当三齿双阴离子[Se–N–O] 2-配体，这已通过Pd衍生物的单晶X射线衍射证实。

  DOI：

  10.1016/j.jorganchem.2010.03.029
• 作为产物：
  描述：

  水杨醛 、 acetone selenosemicarbazone 在 水 、 溶剂黄146 作用下， 生成 Salicylaldehyd-selenosemicarbazon
  参考文献：
  名称：

  The Anticalcific Effect of Glutaraldehyde Detoxification on Bioprosthetic Aortic Wall Tissue in the Sheep Model

  摘要：

  Background: Increasing concentrations of glutaraldehyde (GA) lead to a decreased rather than increased calcification of bioprosthetic aortic wall tissue. This study determined to what extent the benefit of better cross-linking is masked by the intrinsic propensity of GA towards calcification. Materials and Methods: Porcine aortic roots were immediately fixed at the abattoir at three different concentrations of GA (0.2%, 1.0%, and 3.0% for 1 week at 4 C). Subsequently, roots underwent a GA extraction process using high volumes of Urazole solution (acetic acid buffer, pH 4.5, 37degreesC, 1 week) followed by NaBH4 reduction (2 days, 37 C). Roots were implanted in the distal aortic arch of young sheep for 6 weeks and 6 months. Calcium analysis was quantitatively done by atomic absorption spectrophotometry and qualitatively assessed by light microscopy on Von Kossa stains. Results: There was a distinct anticalcification effect of GA detoxification after 6 weeks (56.8% to 97.9%; 95% confidence interval [CI]), which stabilized on a more moderate level after 6 months of implantation (19.1% to 31.6%; 95% CI). The most pronounced effect of GA extraction was seen in 0.2% fixed tissue, where aortic wall calcification was mitigated by 97% and 32% after 6 weeks and 6 months, respectively. Mitigation of aortic wall calcification was 71% (6 weeks) and 21% (6 months) in the 3.0% GA group. The combined effect of higher cross-link density and detoxification achieved an 82% (6 weeks) and 48% (6 months) reduction of calcium levels in the 3.0% GA group. In long-term implants (6 months), detoxification alone on top of standard 0.2% GA fixation was as effective (from 174.1 +/- 11.9 mug/mg without detoxification to 119.3 +/- 19.3 mug/mg with detoxification) as 3.0% fixation (114.8 +/- 10.0 mug/mg without detoxification to 91.3 +/- 11.5 mug/mg with detoxification). Conclusion: We were able to determine in the circulatory sheep model to what degree the intrinsic procalcific effect of GA counteracts the protective effect of higher cross-link density. Our study also established that the effect of detoxification is particularly pronounced in commercial low-grade fixation.

  DOI：

  10.1111/j.1540-8191.2001.tb00551.x