2-methoxyisoquinoline-1,3(2H,4H)-dione | 22367-15-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 2-methoxyisoquinoline-1,3(2H,4H)-dione
• 英文别名: 2-Methoxy-4H-isoquinoline-1,3-dione
• CAS: 22367-15-3
• 化学式: C₁₀H₉NO₃
• 分子量: 191.186
• InChiKey: HHKIUDKKXUHHKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methoxyisoquinoline-1,3(2H,4H)-dione 在 硼烷 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以68%的产率得到N-甲氧基异喹啉酮
  参考文献：
  名称：

  通过Rh（III）催化的类胡萝卜素插入CH活化/环化一锅级联合成N-甲氧基异喹啉二酮。

  摘要：

  在这里，已经实现了一种新的，温和且通用的方法，该方法可通过Rh（III）催化的区域选择性类胡萝卜素插入反应，通过N-甲氧基苯甲酰胺与α-重氮基的Meldrum酸进行CH活化/环化，一锅级联合成各种N-甲氧基异喹啉二酮。还证明了开发的Rh（III）催化作用的扩展，以构建市售药物Edaravone的新类似物。

  DOI：

  10.1039/c4cc08407a
• 作为产物：
  描述：

  苯甲酰氯 在 bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] 、 potassium carbonate 、 双三氟甲烷磺酰亚胺银盐 作用下， 以 水 、 乙酸乙酯 、 1,2-二氯乙烷 为溶剂， 反应 5.0h， 生成 2-methoxyisoquinoline-1,3(2H,4H)-dione
  参考文献：
  名称：

  Ir(III)-Catalyzed Carbenoid Functionalization of Benzamides: Synthesis of N-Methoxyisoquinolinediones and N-Methoxyisoquinolinones

  摘要：

  A mild and efficient Ir(III)-catalyzed C-H carbenoid functionalization strategy has been developed to access. N-methoxyisoquinolinediones and N-methoxyisoquinolinones. The reaction proceeds efficiently in high yield at room temperature over a broad range of substrates without requirement of any additional oxidants or a base.

  DOI：

  10.1021/acs.orglett.6b01072

文献信息

• Iridium(III)-Catalyzed Regioselective Carbenoid Insertion C-H Alkylation by α-Diazotized Meldrum's Acid
  作者：Honggui Lv、William L. Xu、Kunhua Lin、Jingjing Shi、Wei Yi

  DOI：10.1002/ejoc.201601212

  日期：2016.12

  straightforward protocol for IrIII-catalyzed regioselective carbenoid insertion C–H alkylation mediated by α-diazotized Meldrum's acid was developed. The assistance of external additives and oxidants was not needed, and the developed IrIII catalysis proceeds in a highly efficient manner (e.g., mild reaction conditions, short reaction times and excellent regioselectivity) and demonstrates good compatibility

  开发了一种实用且直接的协议，用于由 α-重氮化的 Meldrum 酸介导的 IrIII 催化的区域选择性卡宾插入 C-H 烷基化。不需要外部添加剂和氧化剂的帮助，所开发的 IrIII 催化以高效的方式进行（例如，温和的反应条件、短的反应时间和出色的区域选择性），并与几种特殊底物（例如有价值的 N- (2-嘧啶基)吲哚、苯基吡啶和市售药物依达拉奉及其类似物，从而为之前快速构建相应烷基化产物的方法提供了很好的补充。
• RUBBER COMPOSITION AND VULCANIZATION AID
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20170130028A1

  公开（公告）日：2017-05-11

  A rubber composition comprising a compound having one or more groups represented by formula (X) and a rubber component is provided. wherein ring W 1 represents a cyclic group having at least one selected from the group consisting of —C(═O)— and —C(═S)—; N 10 represents a nitrogen atom; the at least one selected from the group consisting of —C(═O)— and —C(═S)— in the ring W 1 and N 10 are conjugated; and Z 1 represents —O— or —S—.

  提供一种橡胶组合物，包括具有一个或多个由式（X）表示的基团和橡胶组分，其中环W1代表具有至少一种从羰基和硫代基组成的群中选出的环；N10代表氮原子；环W1和N10中所选的至少一种从羰基和硫代基组成的群是共轭的；Z1代表氧或硫。
• 1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides used as anti-inflammatory
  申请人：Pfizer Inc.

  公开号：US03998954A1

  公开（公告）日：1976-12-21

  1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides, nuclear unsubstituted and substituted, are prepared by reacting the appropriate homophthalimide with potassium cyanate. Secondary carboxamides are prepared by reacting homophthalimide with appropriate isocyanates, and tertiary carboxamides are prepared by aminolysis of 4-carbalkoxy compounds, which are in turn prepared by alcoholysis of the corresponding 4-carboxanilides. Corresponding 5,6,7,8-tetrahydro compounds are similarly prepared. The various 2-substituted homophthalimides are prepared by reacting homophthalic acid with appropriate amine. The 4-carboxamides are anti-inflammatory agents.

  1,3(2H,4H)-二氧化异喹啉-4-羧酰胺，核未取代和取代的，是通过将适当的同苯二酰亚胺与氰酸钾反应制备的。次级羧酰胺是通过将同苯二酰亚胺与适当的异氰酸酯反应制备的，而三级羧酰胺则是通过4-羧基烷氧基化合物的氨解反应制备的，这些化合物又是通过相应的4-羧基苯甲酰胺的醇解制备的。相应的5,6,7,8-四氢化合物也是类似地制备的。各种2-取代同苯二酰亚胺是通过将同苯二甲酸与适当的胺反应制备的。4-羧酰胺是抗炎药物。
• Rubber composition and vulcanization aid
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US10287419B2

  公开（公告）日：2019-05-14

  A rubber composition comprising a compound having one or more groups represented by formula (X) and a rubber component is provided. wherein ring W1 represents a cyclic group having at least one selected from the group consisting of —C(═O)— and —C(═S)—; N10 represents a nitrogen atom; the at least one selected from the group consisting of —C(═O)— and —C(═S)— in the ring W1 and N10 are conjugated; and Z1 represents —O— or —S—.

  提供了一种橡胶组合物，该组合物由具有一个或多个由式 (X) 表示的基团的化合物和橡胶成分组成。 其中环 W1 代表环状基团，该环状基团至少有一个选自-C(═O)- 和-C(═S)- 组成的组；N10 代表氮原子；环 W1 和 N10 中至少一个选自-C(═O)- 和-C(═S)- 组成的组是共轭的；Z1 代表-O- 或-S-。
• Imide Compound and Chemically Amplified Resist Composition Containing The Same
  申请人：TAKEMOTO Ichiki

  公开号：US20100028807A1

  公开（公告）日：2010-02-04

  An imide compound represented by the formula (I): wherein R 1 represents a C1-C20 aliphatic hydrocarbon group etc., W 1 represents —CO—O— etc., Q 1 and Q 2 each independently represent a fluorine atom etc., and A represents a group represented by the formula (I-1): wherein A 1 represents —CH 2 —CH 2 — etc., and a chemically amplified resist composition containing the same.