((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-(4-nitro-benzyl)-propyl-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: ((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-(4-nitro-benzyl)-propyl-amine
• 英文别名: (2R)-5-methoxy-N-[(4-nitrophenyl)methyl]-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine
• 化学式: C₂₁H₂₆N₂O₃
• 分子量: 354.449
• InChiKey: OQFVFESDHDATCZ-LJQANCHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  58.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (R)-(+)-2-(N-benzylamino)-5-methoxytetralin 在 palladium on activated charcoal 盐酸 、 氢气 、 sodium cyanoborohydride 、 potassium carbonate 、 溶剂黄146 作用下， 以 甲醇 、 乙腈 为溶剂， 生成 ((R)-5-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-(4-nitro-benzyl)-propyl-amine
  参考文献：
  名称：

  Derivatives of (R)-2-amino-5-methoxytetralin: Antagonists and inverse agonists at the dopamine D2a receptor

  摘要：

  A series of N-arylmethyl substituted (R)-5-methoxy-2-(propylamino)tetralins has been prepared and evaluated for affinity and efficacy at dopamine (DA) D-2A receptors. The novel compounds appeared to be antagonists or inverse agonists. (R)-2-[(Benzyl)propylamino]-5-methoxytetralin (7) was characterized as a potent inverse agonists at DA D-2A receptors in a [S-35]GTP gamma S binding assay. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00345-5

文献信息

• Derivatives of (R)-2-amino-5-methoxytetralin: Antagonists and inverse agonists at the dopamine D2a receptor
  作者：Berit Backlund Höök、Cecilia Brege、Tero Linnanen、Åsa Mikaels、Åsa Malmberg、Anette M. Johansson

  DOI：10.1016/s0960-894x(99)00345-5

  日期：1999.8

  A series of N-arylmethyl substituted (R)-5-methoxy-2-(propylamino)tetralins has been prepared and evaluated for affinity and efficacy at dopamine (DA) D-2A receptors. The novel compounds appeared to be antagonists or inverse agonists. (R)-2-[(Benzyl)propylamino]-5-methoxytetralin (7) was characterized as a potent inverse agonists at DA D-2A receptors in a [S-35]GTP gamma S binding assay. (C) 1999 Elsevier Science Ltd. All rights reserved.