4-(三氟甲基)苯甲醛水合物 | 85152-58-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(三氟甲基)苯甲醛水合物
• 英文名称: 4-(trifluoromethyl)benzaldehyde hydrate
• 英文别名: 4-(Trifluoromethyl)phenylmethanediol；[4-(trifluoromethyl)phenyl]methanediol
• CAS: 85152-58-5
• 化学式: C₈H₇F₃O₂
• 分子量: 192.138
• InChiKey: YKGUNGCZGKOKDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-(三氟甲基)苯甲醛水合物 以 水 为溶剂， 生成 对三氟甲基苯甲醛
  参考文献：
  名称：

  Structure-reactivity effects in the hydration of benzaldehydes

  摘要：

  DOI：

  10.1021/ja00347a033
• 作为产物：
  描述：

  对三氟甲基苯甲醛 生成 4-(三氟甲基)苯甲醛水合物
  参考文献：
  名称：

  Stewart, Ross, Canadian Journal of Chemistry, 1984, vol. 62, p. 907 - 910

  摘要：

  DOI：

文献信息

• Rhodium-catalyzed decarbonylation cross-coupling reactions of aromatic aldehydes and arylboronic acids via C C bond activation directed by a guide group chelation
  作者：Xiaobo Yu、Guanchen Liu、Shudong Geng

  DOI：10.1016/j.inoche.2020.108065

  日期：2020.9

  Abstract A rhodium-catalyzed decarbonylative cross-coupling reaction of benzoquinoline-10-carbaldehydes with arylboronic acids through chelation-assisted sp2 C−CHO bond activation has been developed. A variety of functional groups substituted phenylboronic acids or benzoquinoline-10-carbaldehydes are compatible with the reaction under the optimized reaction conditions, the corresponding 10-phenylbenzo[h]quinoline

  摘要 已经开发了铑催化的苯并喹啉-10-甲醛与芳基硼酸通过螯合辅助 sp2 C-CHO 键活化的脱羰交叉偶联反应。在优化的反应条件下，多种官能团取代的苯基硼酸或苯并喹啉-10-甲醛与反应相容，相应的10-苯基苯并[h]喹啉衍生物以中等至良好的收率获得。该方法为通过铑催化的 sp2 C-CHO 键活化合成 N-杂环联芳基化合物提供了一种有用的策略。
• Curcumol derivatives, the compositions containing the said derivatives, and the use of the same in the manufacture of medicaments
  申请人：Wang Shulong

  公开号：US20070191360A1

  公开（公告）日：2007-08-16

  The present invention provides curcumol derivatives of the following formula (I) or pharmaceutical acceptable salts thereof: wherein, Y is selected from the group consisting of ═CHR 2 , —CH 2 R 2 , ═O, —OH or —OR 1 ;R 1 is selected from H, R, RCO or HO 3 S; and R is selected from the group consisting of H; saturated or unsaturated linear C 1-10 hydrocarbon group and the like; R 2 is selected from the group consisting of F; Cl; Br; I; H; —OH; —OR; —HSO 3 and the like; with the proviso that both R 1 and R 2 are not H. The present invention also provides anti-tumor or antiviral pharmaceutical compositions comprising said derivatives or pharmaceutical acceptable salts thereof. The present invention further provides the use of said derivatives or pharmeceutical acceptable salts thereof in the preparation of a medicament for prophylaxis and/or treatment tumor or an antiviral medicament.

  本发明提供以下式（I）的姜黄醇衍生物或其药学上可接受的盐：其中，Y选自 ═CHR2，—CH2R2，═O，—OH或—OR1的群组；R1选自H，R，RCO或HO3S；R选自H；饱和或不饱和的线性C1-10烃基等群组；R2选自F，Cl，Br，I，H，—OH，—OR，—HSO3等群组；但要求R1和R2均不为H。本发明还提供包含上述衍生物或其药学上可接受的盐的抗肿瘤或抗病毒药物组合物。本发明还提供使用上述衍生物或其药学上可接受的盐制备预防和/或治疗肿瘤或抗病毒药物的药物。
• FLUORINATED AROMATIC ACETAL POLYMERS AND PHOTOSENSITIVE COMPOSITIONS CONTAINING SUCH POLYMERS
  申请人：Kodak Polychrome Graphics L.L.C.

  公开号：US20020146633A1

  公开（公告）日：2002-10-10

  A novel fluorinated aromatic acetal polymer comprises at least one unit of A and at least one unit of B or C, or at least one unit of each of A, B and C and optionally further comprises at least one unit of either D or E or at least one unit of each of D and E, wherein the units A and B and/or C, and optionally D and/or E are linked together by single covalent C-C bonds and have the formulae: 1 wherein R A is H or C 1 -C 11 alkyl, or an aryl group that does not contain fluorine, and R B and R C are an aryl groups that contain fluorine. The polymer is prepared by reacting a hydrolyzed polyvinyl acetate polymer or copolymer with at least one non-fluorinated aldehyde component, and at least one fluorinated aromatic component. The polymer is useful is preparing a photosensitive composition which comprises at least one diazo resin and at least one such fluorinated aromatic acetal polymer. Such a photosensitive composition may be applied to a support to form an imageable member which may be imaged to form a lithographic printing plates.p

  一种新型氟化芳香族缩醛聚合物包含至少一个 A 单元和至少一个 B 或 C 单元，或 A、B 和 C 中各自的至少一个单元，并可选地进一步包含至少一个 D 或 E 单元，或 D 和 E 中各自的至少一个单元，其中单元 A 和 B 和/或 C，以及可选的 D 和/或 E 通过单个共价 C-C 键连接在一起，并具有以下式子： 1 其中 R A 是 H 或 C 1 -C 11 烷基或不含氟的芳基，以及 R B 和 R C 是含氟的芳基。该聚合物的制备方法是将水解聚醋酸乙烯酯聚合物或共聚物与至少一种非氟化醛组分和至少一种氟化芳香组分反应。这种聚合物可用于制备光敏组合物，其中包括至少一种重氮树脂和至少一种此类氟化芳香族缩醛聚合物。这样的光敏组合物可涂在支撑物上形成可成像部件，该部件可成像以形成平版印刷板。
• US6458503B1
  申请人：——

  公开号：US6458503B1

  公开（公告）日：2002-10-01
• US7700584B2
  申请人：——

  公开号：US7700584B2

  公开（公告）日：2010-04-20