3-chloromethyl-2,4-dimethyl-penta-1,3-diene | 85371-20-6

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: 3-chloromethyl-2,4-dimethyl-penta-1,3-diene
• 英文别名: 3-(Chloromethyl)-2,4-dimethylpenta-1,3-diene
• CAS: 85371-20-6
• 化学式: C₈H₁₃Cl
• mdl: MFCD19232405
• 分子量: 144.644
• InChiKey: VAJAZPDAQSZTDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  3-chloromethyl-2,4-dimethyl-penta-1,3-diene 在 仲丁基锂 、 magnesium 作用下， 生成 1-[2-(3-Isopropenyl-4-methyl-pent-3-enyl)-phenyl]-prop-2-en-1-ol
  参考文献：
  名称：

  Shea, Kenneth J.; Davis, Peter D., Angewandte Chemie, 1983, vol. 95, # 5, p. 422 - 423

  摘要：

  DOI：
• 作为产物：
  描述：

  (3-methyl-2-methylethenyl)-2-buten-1-ol 在 2,3,5-三甲基吡啶 、 甲基磺酰氯 、 lithium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.3h， 以64%的产率得到3-chloromethyl-2,4-dimethyl-penta-1,3-diene
  参考文献：
  名称：

  Diastereomeric atropisomers of the tricyclo[9.3.1.03,8]pentadecane ring system. Synthesis and structural studies

  摘要：

  DOI：

  10.1021/ja00276a041

文献信息

• The chemistry of C-aromatic taxane derivatives atropisomer control of reaction stereochemistry
  作者：Randy W. Jackson、Richard G. Higby、Jeffrey W. Gilman、Kenneth J. Shea

  DOI：10.1016/s0040-4020(01)91211-6

  日期：1992.1

  The atropselective synthesis of tricyclo [9.3.1.03,8] pentadecane ring systems is reported. Substrate conformation is utilized for the stereoselective elaboration of functional groups. The conformational dynamics of intermediates are also reported.

  报道了三环[9.3.1.0 3,8 ]十五烷环系统的对映选择性合成。底物构象用于官能团的立体选择性修饰。还报道了中间体的构象动力学。
• The [4+2], [2+2] strategy for the construction of the AB taxane ring system
  作者：Phannarath Phansavath、Corinne Aubert、Max Malacria

  DOI：10.1016/s0040-4039(97)10867-x

  日期：1998.3

  The construction of the AB taxane ring system through a [4+2] reaction and Co(I)-[2+2] cyclization is presented. For the first time, CpCo(CO)2 catalyzes the ring closure of strained polyunsaturated triynic compound into eight-membered ring.

  提出了通过[4 + 2]反应和Co（I）-[2 + 2]环化的AB紫杉烷环系统的构建。CpCo（CO）2首次将应变的多不饱和Triynic化合物的闭环催化成八元环。
• Polymeric photo active agents
  申请人：Hewlett-Packard Development Company, L.P.

  公开号：US10619030B2

  公开（公告）日：2020-04-14

  The present disclosure is drawn to a polymeric photo active agent which includes diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide modified with a polyether having from 2 to 200 ether groups.

  本公开涉及一种聚合物光活性剂，它包括用具有 2 至 200 个醚基的聚醚修饰的二苯基（2,4,6-三甲基苯甲酰基）氧化膦。
• New Efficient Construction of the ABC Core of the Taxoids via a Sequence of Consecutive Cobalt(I)-Mediated [2 + 2 + 2] and [4 + 2] Cyclizations
  作者：Marc Petit、Gaëlle Chouraqui、Phannarath Phansavath、Corinne Aubert、Max Malacria

  DOI：10.1021/ol025623r

  日期：2002.3.1

  [GRAPHICS]A new and efficient sequence of two consecutive cyclizations, a cobalt(I)-mediated [2 + 2 + 2] cyclotrimerization and a Diels-Alder reaction, is proposed to allow the formation of the ABC core of the taxoids in 65% overall yield, starting from an acyclic polyunsaturated precursor.
• POLYMERIC PHOTO ACTIVE AGENTS
  申请人：Hewlett-Packard Development Company, L.P.

  公开号：US20190233617A1

  公开（公告）日：2019-08-01

  The present disclosure is drawn to a polymeric photo active agent which includes diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide modified with a polyether having from 2 to 200 ether groups.