(R)-<<(tetranitrofluorenylidene)amino>oxy>propionic acid | 50874-31-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (R)-<<(tetranitrofluorenylidene)amino>oxy>propionic acid
• 英文别名: (R)-2-(2,4,5,7-Tetranitrofluoren-9-ylideneaminooxy)propionic acid；R(-)2-(2,4,5,7-tetranitro-9-fluorenyloximino)propanoic acid；(R)-2-(2,4,5,7-tetranitro-fluoren-9-ylidenaminooxy)-propionic acid；(R)-2-(2,4,5,7-Tetranitro-fluoren-9-ylidenaminooxy)-propionsaeure；(-)-TAPA；(-)-Alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminoxy)propionic acid；(2R)-2-[(2,4,5,7-tetranitrofluoren-9-ylidene)amino]oxypropanoic acid
• CAS: 50874-31-2
• 化学式: C₁₆H₉N₅O₁₁
• 分子量: 447.274
• InChiKey: MQTMHRXULFJFOC-ZCFIWIBFSA-N

物化性质

• 熔点：
  196-199 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  242
• 氢给体数：
  1
• 氢受体数：
  12

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38

反应信息

• 作为反应物：
  描述：

  (R)-<<(tetranitrofluorenylidene)amino>oxy>propionic acid 、 (+/-)-sec-butyl-[1]naphthyl ether 生成 sec-butyl-[1]naphthyl ether
  参考文献：
  名称：

  α-(2,4,5,7-Tetranitro-9-fluorenylideneaminoöxy)-propionic Acid, a New Reagent for Resolution by Complex Formation¹

  摘要：

  DOI：

  10.1021/ja01592a034
• 作为产物：
  描述：

  甲醇 、 (R)-2-isopropylidenaminooxy-propionic acid 在 硫酸 作用下， 生成 (R)-<<(tetranitrofluorenylidene)amino>oxy>propionic acid
  参考文献：
  名称：

  Application of NMR spectroscopy of chiral association complexes. 13—electron donor-acceptor complexes between racemic carbazolo[3,4-c]carbazoles and an optically active acceptor

  摘要：

  AbstractStrong electron donor–acceptor (EDA) association between carbazolo[3,4‐c]carbazoles and an optically active tetranitrofluorenone derivative was detected by UV–visible spectroscopy and by 1H NMR shifts. 1H NMR splittings at low temperatures are due to diastereomeric association complexes and, thus, prove the chirality of carbazolocarbazoles.

  DOI：

  10.1002/mrc.1270200306

文献信息

• Camptothecin derivatives as chemoradiosensitizing agents
  申请人：Yang Li-Xi

  公开号：US20070093432A1

  公开（公告）日：2007-04-26

  Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.

  基于紫杉醇的化合物通过将该化合物与放射疗法结合在一起向哺乳动物体内施用，对治疗肿瘤具有益处，即使用放射性物质或来自主体外部源的辐射治疗肿瘤。通过在紫杉醇结构周围定位至少一个电子亲和基团来改性基于紫杉醇的化合物，以增强它们与放射疗法结合的价值。还披露了新的基于紫杉醇的化合物，可通过单独或与放射疗法结合使用这些新化合物来治疗癌症。
• CAMPTOTHECIN DERIVATIVES AS CHEMORADIOSENSITIZING AGENTS
  申请人：YANG Li-Xi

  公开号：US20080318873A1

  公开（公告）日：2008-12-25

  Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.

  基于喜树碱的化合物可用于治疗哺乳动物主体中的肿瘤，通过将该化合物与放射治疗结合给予主体治疗，即使用放射性物质或来自主体外部的辐射治疗肿瘤。将至少一个电子亲和基团定位于喜树碱结构周围，以增强其与放射治疗结合的价值而改性基于喜树碱的化合物。揭示了新的基于喜树碱的化合物，可通过单独或与放射治疗结合给予治疗，用于治疗癌症。
• 634. The preparation of optically active phosphorus compounds
  作者：M. Green、R. F. Hudson

  DOI：10.1039/jr9580003129

  日期：——
• The Synthesis and Resolution of Hexahelicene¹
  作者：Melvin S. Newman、Daniel Lednicer

  DOI：10.1021/ja01599a060

  日期：1956.9
• Correlation between the stability and structure of diastereomeric charge-transfer complexes in solution. (P)-[7]Thiaheterohelicene and (S)- and (R)-[[(tetranitrofluorenylidene)amino]oxy]propionic acid pairs
  作者：Hiroko Nakagawa、Hisao Tanaka、Kohichi Yamada、Hiroshi Kawazura

  DOI：10.1021/j100210a013

  日期：1982.6