5-Phenyl-4-acetyl-pentansaeure-nitril | 91956-52-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Phenyl-4-acetyl-pentansaeure-nitril
• 英文别名: 4-benzyl-5-oxo-hexanenitrile；4-Benzyl-5-oxo-hexannitril；4-Benzyl-5-oxohexanenitrile
• CAS: 91956-52-4
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: PHIJSPDWWIZJII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 5-Phenyl-4-acetyl-pentansaeure-nitril
  参考文献：
  名称：

  Removal of bowel aerobic gram-negative bacteria is more effective than immunosuppression with cyclophosphamide and steroids to decrease natural α-Galactosyl IgG antibodies

  摘要：

  Abstract: Natural α‐Galactosyl (Gal) antibodies play an important role in the rejection of pig xenografts by humans and Old World monkeys. In this study we investigate the efficacy of two different strategies to reduce the serum level of natural anti‐Gal antibodies. On the one hand, removal of aerobic gram‐negative bacteria from the intestinal flora, because anti‐Gal antibodies appear to be produced as a result of the continuous sensitization by these microorganisms. On the other hand, we studied the effect on these antibodies of an immunosuppressive regimen of cyclophosphamide and steroids. Ten baboons were treated for three months with norfloxacin (Nor Group; n = 6) or cyclophosphamide and steroids (CyP Group; n = 4). A further four baboons did not receive any treatment (Control Group). Aerobic gram‐negative bacteria became negative in stools of the Nor Group after two weeks of treatment, and remained undetectable until week 7. Thereafter, a gradual increase on the fecal concentration of aerobic gram‐negative bacteria was observed despite the norfloxacin treatment. The mean anti‐Gal IgG in the Nor Group gradually declined from week 4 to 9 to a mean of 62.7 ± 18% of the baseline level, and during this period were significantly lower than in the CyP (P < 0.02) and the Control (P < 0.05) groups. No differences were observed between the three groups during the 16 weeks of follow‐up in serum levels of anti‐Gal IgM, hemolytic anti‐pig antibodies, total IgG, IgM and IgA. In conclusion, removal of normal aerobic gram‐negative bacteria from the intestinal flora is more effective than immunosuppression with CyP and steroids in reducing the level of natural anti‐Gal antibodies, although there is no discernible effect on IgM antibodies.

  DOI：

  10.1034/j.1399-3089.2001.00082.x

文献信息

• Yue et al., Huaxue Xuebao/Acta Chimica Sinica, 1959, vol. 25, p. 146,147
  作者：Yue et al.

  DOI：——

  日期：——
• Naeslund,G. et al., Acta Chemica Scandinavica (1947), 1962, vol. 16, p. 1324 - 1328
  作者：Naeslund,G. et al.

  DOI：——

  日期：——
• US5344983A
  申请人：——

  公开号：US5344983A

  公开（公告）日：1994-09-06
• Removal of bowel aerobic gram-negative bacteria is more effective than immunosuppression with cyclophosphamide and steroids to decrease natural α-Galactosyl IgG antibodies
  作者：Rafael Mañez、Francisco J. Blanco、Inmaculada Díaz、Alberto Centeno、Eduardo Lopez-Pelaez、Manuel Hermida、Hugh F. S. Davies、Andreas Katopodis

  DOI：10.1034/j.1399-3089.2001.00082.x

  日期：2001.2

  Abstract: Natural α‐Galactosyl (Gal) antibodies play an important role in the rejection of pig xenografts by humans and Old World monkeys. In this study we investigate the efficacy of two different strategies to reduce the serum level of natural anti‐Gal antibodies. On the one hand, removal of aerobic gram‐negative bacteria from the intestinal flora, because anti‐Gal antibodies appear to be produced as a result of the continuous sensitization by these microorganisms. On the other hand, we studied the effect on these antibodies of an immunosuppressive regimen of cyclophosphamide and steroids. Ten baboons were treated for three months with norfloxacin (Nor Group; n = 6) or cyclophosphamide and steroids (CyP Group; n = 4). A further four baboons did not receive any treatment (Control Group). Aerobic gram‐negative bacteria became negative in stools of the Nor Group after two weeks of treatment, and remained undetectable until week 7. Thereafter, a gradual increase on the fecal concentration of aerobic gram‐negative bacteria was observed despite the norfloxacin treatment. The mean anti‐Gal IgG in the Nor Group gradually declined from week 4 to 9 to a mean of 62.7 ± 18% of the baseline level, and during this period were significantly lower than in the CyP (P < 0.02) and the Control (P < 0.05) groups. No differences were observed between the three groups during the 16 weeks of follow‐up in serum levels of anti‐Gal IgM, hemolytic anti‐pig antibodies, total IgG, IgM and IgA. In conclusion, removal of normal aerobic gram‐negative bacteria from the intestinal flora is more effective than immunosuppression with CyP and steroids in reducing the level of natural anti‐Gal antibodies, although there is no discernible effect on IgM antibodies.