1,3,3-三甲基-1,3-二氢-2H-吡咯并[2,3-b]吡啶-2-酮 | 127555-22-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 中文名称: 1,3,3-三甲基-1,3-二氢-2H-吡咯并[2,3-b]吡啶-2-酮
• 英文名称: 1,3,3-trimethyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one
• 英文别名: 1,3,3-trimethylpyrrolo[2,3-b]pyridin-2-one
• CAS: 127555-22-0
• 化学式: C₁₀H₁₂N₂O
• 分子量: 176.218
• InChiKey: MDYXRVRZZPXLLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 fac-tris(2-phenylpyridinato-N,C2')iridium(III) 、 N,N-二异丙基乙胺 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 60.0h， 以65%的产率得到1,3,3-三甲基-1,3-二氢-2H-吡咯并[2,3-b]吡啶-2-酮
  参考文献：
  名称：

  可见光光氧化还原催化芳基碘的分子内1，5-H转移反应：一种合成天然产物支架的简明方法

  摘要：

  描述了通过光催化由未活化的芳基碘化物产生的芳基的分子内1，5-H转移反应。这种转变的特点是操作简便，产量高，反应温和...

  DOI：

  10.1039/c6cc02007k

文献信息

• Intramolecular 1,5-H transfer reaction of aryl iodides through visible-light photoredox catalysis: a concise method for the synthesis of natural product scaffolds
  作者：Jian-Qiang Chen、Yun-Long Wei、Guo-Qiang Xu、Yong-Min Liang、Peng-Fei Xu

  DOI：10.1039/c6cc02007k

  日期：——

  The intramolecular 1,5-H transfer reaction of the aryl radicals generated from unactivited aryl iodides by photocatalysis is described. The features of this transformation are operational simplicity, excellent yields, mild reaction...

  描述了通过光催化由未活化的芳基碘化物产生的芳基的分子内1，5-H转移反应。这种转变的特点是操作简便，产量高，反应温和...
• Heterobicyclic compounds having antiinflammatory activity
  申请人：Schering Corporation

  公开号：US05182289A1

  公开（公告）日：1993-01-26

  Heterobicyclic and heterocyclic intermediate compounds and their use in treating inflammation, hyperproliferative skin conditions such as psoriasis and allergy are disclosed.

  异双环和杂环中间化合物及其在治疗炎症、过度增生性皮肤病（如牛皮癣）和过敏中的应用被揭示。
• 1H-IMIDAZO[4,5-C]QUINOLINONE DERIVATIVES
  申请人：Furet Pascal

  公开号：US20140005163A1

  公开（公告）日：2014-01-02

  The invention relates to the use of 1H-imidazo[4,5-c]quinolinone derivatives and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1H-imidazo[4,5-c]quinolinone derivatives for use in the treatment of protein and/or lipid kinase dependent diseases; a method of treatment against said diseases, comprising administering the 1H-imidazo[4,5-c]quinolinone derivatives to a warm-blooded animal, especially a human; pharmaceutical preparations comprising an 1H-imidazo[4,5-c]quinolinone derivative, especially for the treatment of a protein and/or lipid kinase dependent disease; novel 1H-imidazo[4,5-c]quinolinone derivatives; and a process for the preparation of the novel 1H-imidazo[4,5-c]quinolinone derivatives.

  本发明涉及使用1H-咪唑[4,5-c]喹啉酮衍生物及其盐治疗蛋白质和/或脂质激酶依赖性疾病，并用于制备治疗该类疾病的药物制剂；使用1H-咪唑[4,5-c]喹啉酮衍生物治疗蛋白质和/或脂质激酶依赖性疾病；一种治疗该类疾病的方法，包括向温血动物，特别是人类，给予1H-咪唑[4,5-c]喹啉酮衍生物；包含1H-咪唑[4,5-c]喹啉酮衍生物的药物制剂，特别用于治疗蛋白质和/或脂质激酶依赖性疾病；新型1H-咪唑[4,5-c]喹啉酮衍生物；以及制备新型1H-咪唑[4,5-c]喹啉酮衍生物的方法。
• 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES
  申请人：FURET Pascal

  公开号：US20100317657A1

  公开（公告）日：2010-12-16

  The invention relates to the use of 1H-imidazo[4,5-c]quinolinone derivatives and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1H-imidazo[4,5-c]quinolinone derivatives for use in the treatment of protein and/or lipid kinase dependent diseases; a method of treatment against said diseases, comprising administering the 1H-imidazo[4,5-c]quinolinone derivatives to a warm-blooded animal, especially a human; pharmaceutical preparations comprising an 1H-imidazo[4,5-c]quinolinone derivative, especially for the treatment of a protein and/or lipid kinase dependent disease; novel 1H-imidazo[4,5-c]quinolinone derivatives; and a process for the preparation of the novel 1H-imidazo[4,5-c]quinolinone derivatives.

  本发明涉及使用1H-咪唑[4,5-c]喹啉酮衍生物及其盐在治疗蛋白质和/或脂质激酶依赖性疾病和制造治疗该类疾病的药物制剂；1H-咪唑[4,5-c]喹啉酮衍生物用于治疗蛋白质和/或脂质激酶依赖性疾病；一种治疗上述疾病的方法，包括向温血动物，特别是人类，给予1H-咪唑[4,5-c]喹啉酮衍生物；包括1H-咪唑[4,5-c]喹啉酮衍生物的药物制剂，特别用于治疗蛋白质和/或脂质激酶依赖性疾病；新型1H-咪唑[4,5-c]喹啉酮衍生物；以及制备新型1H-咪唑[4,5-c]喹啉酮衍生物的方法。
• Photoinduced halogen-bonding enabled synthesis of oxindoles and isoindolinones from aryl iodides
  作者：Wen-Xin Tang、Kun-Quan Chen、De-Qun Sun、Xiang-Yu Chen

  DOI：10.1039/d2ob01818g

  日期：——

  halogen bonding (XB) for the generation of aryl radicals from aryl halides under blue light irradiation and applied it in radical generation/1,5-hydrogen-atom transfer/radical cyclization cascade reactions for the synthesis of oxindoles and isoindolinones. On the basis of experimental studies, we propose that DBU can serve as a suitable XB acceptor with aryl halides for the formation of a photoactive

  我们报道了卤键 (XB) 在蓝光照射下从芳基卤化物生成芳基自由基的用途，并将其应用于自由基生成/1,5-氢原子转移/自由基环化级联反应以合成羟吲哚和异吲哚啉酮. 在实验研究的基础上，我们提出 DBU 可以作为合适的 XB 受体与芳基卤化物形成光活性电子供体和受体复合物。