(2,5-Dioxopyrrolidin-1-yl) 5-[4-[(1,4-dioxo-2,3-dihydrophthalazin-6-yl)-ethylamino]butylamino]-5-oxopentanoate | 1447010-87-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (2,5-Dioxopyrrolidin-1-yl) 5-[4-[(1,4-dioxo-2,3-dihydrophthalazin-6-yl)-ethylamino]butylamino]-5-oxopentanoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 5-[4-[(1,4-dioxo-2,3-dihydrophthalazin-6-yl)-ethylamino]butylamino]-5-oxopentanoate
• CAS: 1447010-87-8
• 化学式: C₂₃H₂₉N₅O₇
• 分子量: 487.513
• InChiKey: YJPNTJBZGAJRFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  35
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  154
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  戊二酸酐 、 N-(4-氨丁基)-N-乙基异鲁米诺 在 吡啶 、 N,N'-二异丙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.33h， 生成 (2,5-Dioxopyrrolidin-1-yl) 5-[4-[(1,4-dioxo-2,3-dihydrophthalazin-6-yl)-ethylamino]butylamino]-5-oxopentanoate
  参考文献：
  名称：

  A new isoluminol reagent for chemiluminescence labeling of proteins

  摘要：

  We report the synthesis and the characterization of N-(4-aminobutyl)-N-ethyl-isoluminol (ABEI) macrocyclic lactone, an activated ester with an unusual macrocyclic structure, and its use for efficient ABEI conjugation to proteins. Compared to the equivalent reagent normally used for chemiluminescence protein labeling, the ABEI macrocyclic lactone displays improved chemical properties, including stability and reactivity. We show the simple synthesis and the use of ABEI macrocyclic lactone for efficient chemiluminescence labeling of monoclonal antibody mixtures currently used in clinical immunodiagnostic assays for the detection of the HIV p24 antigen in patients. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.036

文献信息

• A new isoluminol reagent for chemiluminescence labeling of proteins
  作者：Alessandro Palmioli、Marco Crisma、Cristina Peggion、PierNatale Brusasca、Davide Zanin、Andrea Dal Corso、Paolo Ingallinella、Francesco Peri

  DOI：10.1016/j.tetlet.2013.06.036

  日期：2013.8

  We report the synthesis and the characterization of N-(4-aminobutyl)-N-ethyl-isoluminol (ABEI) macrocyclic lactone, an activated ester with an unusual macrocyclic structure, and its use for efficient ABEI conjugation to proteins. Compared to the equivalent reagent normally used for chemiluminescence protein labeling, the ABEI macrocyclic lactone displays improved chemical properties, including stability and reactivity. We show the simple synthesis and the use of ABEI macrocyclic lactone for efficient chemiluminescence labeling of monoclonal antibody mixtures currently used in clinical immunodiagnostic assays for the detection of the HIV p24 antigen in patients. (C) 2013 Elsevier Ltd. All rights reserved.