N-dodecyl-1,4-butanediamine | 53860-66-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-dodecyl-1,4-butanediamine
• 英文别名: N-laurylbutylenediamine；N~1~-Dodecylbutane-1,4-diamine；N'-dodecylbutane-1,4-diamine
• CAS: 53860-66-5
• 化学式: C₁₆H₃₆N₂
• 分子量: 256.475
• InChiKey: FNOMOLVTRWMYBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  18
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  BOC-L-异亮氨酸 、 N-dodecyl-1,4-butanediamine 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 混旋樟脑磺酸 作用下， 以 二氯甲烷 为溶剂， 以78 %的产率得到
  参考文献：
  名称：

  合成氨基酸衍生物对消化酶的抑制潜力作为有前途的降血糖和抗肥胖剂

  摘要：

  在过去的几十年里，二型糖尿病和肥胖等代谢性疾病发病率的增加促使研究人员研究新的酶抑制剂。在本研究中，使用体外测定评估了合成氨基酸衍生物（PPC80、PPC82、PPC84、PPC89 和 PPC101）对消化酶活性的抑制作用。通过抑制百分比和50%抑制浓度（IC50）确定抑制效果，并使用动力学参数和Lineweaver-Burk图研究作用机制。 PPC80、PPC82 和 PPC84 通过竞争或混合机制抑制胰腺脂肪酶（IC50 为 167–1023 µM）。胰腺 α-淀粉酶的活性被 PPC80、PPC82、PPC84、PPC89 和 PPC101 抑制（IC50 为 162–519 µM），它们充当竞争性或混合抑制剂。最后，PPC84、PPC89 和 PPC101 作为竞争性抑制剂也显示出对 α-葡萄糖苷酶的有效抑制作用（IC50 为 51–353 µM）。结果表明，这些合成氨基酸衍生物对

  DOI：

  10.3390/biom13060953
• 作为产物：
  描述：

  四亚甲基二胺 、 1-氯十二烷 以 乙醇 为溶剂， 反应 24.0h， 生成 N-dodecyl-1,4-butanediamine
  参考文献：
  名称：

  Antifungal activity of aminoalcohols and diamines against dermatophytes and yeast

  摘要：

  Dermatomycoses are infections caused by fungi and yeasts and the drug treatment is considered expensive and extensive. Researchers are synthesizing new organic compounds in order to obtain more effective molecules that provide reduced adverse effects. Our research group has synthesized and evaluated the biological activities of aminoalcohol and diamine derivatives, which were considered active against human pathogenic fungi. Therefore, the objective of this study was to evaluate the in vitro antifungal activity of aminoalcohols and diamine derivatives against fungi and yeasts that cause dermatomycoses. The minimum inhibitory concentrations (MICs) and the minimum fungicidal concentration (MFC) of aminoalcohol (1-4) and diamine (5-13) derivatives was determined againstTrichophyton mentagrophytes,T. rubrum,Epidermophyton floccosum, andCandida albicansaccording to protocols from the Clinical and Laboratory Standards Institute. All molecules exhibited fungicidal activity against the evaluated fungal strains, with the MIC and MFC ranging between 0.12 and 1000 mu g/mL for filamentous fungi and 0.6 and 1250 mu g/mL for yeasts. The best activity was attributed to diamines compared to aminoalcohols, with an emphasis on molecules6 and 7. These results demonstrate the antifungal potential of the evaluated aminoalcohols and diamines against the four primary fungal species that cause dermatomycoses.

  DOI：

  10.1007/s00044-020-02636-y

文献信息

• Dual‐protected amino acid derivatives as new antitubercular agents
  作者：Pedro P. Castro、Débora L. Campos、Fernando R. Pavan、Giovanni W. Amarante

  DOI：10.1111/cbdd.13315

  日期：2018.8

  drug-resistant rates. In an attempt to develop new antitubercular agents, 35 compounds were synthesized, most of them bearing a carbamate and enantiopure amino acid moiety. These compounds had their activity evaluated toward a Mycobacterium tuberculosis strain (ATCC 27294) and cytotoxicity against fibroblast MRC-5 cells (ATCC CCL-171). Three of the prepared derivatives presented a good antimicrobial inhibition

  结核病是一种传染病，发病率高，耐药率不断上升。为了开发新的抗结核药，合成了35种化合物，其中大多数带有氨基甲酸酯和对映体纯氨基酸部分。评估了这些化合物对结核分枝杆菌菌株的活性（ATCC 27294）和对成纤维细胞MRC-5细胞的细胞毒性（ATCC CCL-171）。所制备的三种衍生物具有良好的抗菌抑制作用，其中两种具有中等的细胞毒性。亲脂性似乎在细胞生长活性中起着至关重要的作用，对于具有较高logP的衍生物而言，其效果最佳。
• Cytotoxic Activity of Synthetic Chiral Amino Acid Derivatives
  作者：Pedro de Castro、Raoni Siqueira、Luiza Conforte、Chris Franco、Gustavo Bressan、Giovanni Amarante

  DOI：10.21577/0103-5053.20190157

  日期：——

  series of dual-protected amino acid derivatives was synthesized and evaluated as potential novel anticancer agents. The 40 derivatives were prepared in up to three reaction steps. The cytotoxic activities were screened in vitro against a panel of tumor and nontumor cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among the synthesized derivatives, three of them showed

  癌症是一种慢性退行性疾病，被认为是全球范围内最重要的死亡原因之一。在这种情况下，合成了一系列双重保护的氨基酸衍生物，并将其评估为潜在的新型抗癌药。在多达三个反应步骤中制备了40种衍生物。使用3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化物（MTT）测定体外针对一组肿瘤和非肿瘤细胞的细胞毒性活性。在合成的衍生物中，其中三个显示出对癌细胞有希望的活性，其半数抑制浓度（IC50）在1.7-6.1μM之间。具有脂质亲和性N-烷基二胺部分和受保护的氨基酸支架的最有希望的衍生物显示出对肿瘤细胞的选择性指数为3.4。N-烷基二胺部分似乎在增强抗癌活性中起关键作用。另一方面，氨基酸支架的掺入导致对癌细胞系的选择性增加。
• Thickening compositions and thickened aqueous acid solutions
  申请人：Akzo Nobel N.V.

  公开号：EP0276501A2

  公开（公告）日：1988-08-03

  The invention relates to a thickened aqueous composition incorporating an amine or diamine, carrying at least one nitrogen linked hydrocarbon group which represents a saturated or unsaturated linear or branched alkyl group having at least 10 carbon atoms and preferably 16-24 carbon atoms or an aryl, aralkyl or alkaryl group containing up to 24 carbon atoms, and wherein the optional other nitrogen linked groups are formed by optionally substituted alkyl groups, aryl groups or aralkyl groups or polyalkoxy groups, or wherein the amine is in the form of a heterocyclic ring, con­taining at least two nitrogen atoms, one of which being substituted by amino (lower) alkyl or hydroxy (lower) alkyl, while the ring is further bearing a linear or branched alkyl or alkenyl preferably reacted with fatty acids, or alkenyl group having at least 10 carbon atoms; cumene sulphonate, xylene sulphonate, toluene sulphonate or mixtures thereof, in their acid or salt form; and a weak acid having a pK value > 2,0; and water, wherein optionally one or more cleaning desinfecting and/or odourizing agents may be dissolved or dispersed. The invention also relates to premix compositions composed of above-men­tioned amines and sulphonates, from which the thickened aqueous composi­tions can be prepared by dilution with water or an aqueous solution or suspension and to a process for cleaning non-horizontal surfaces.

  本发明涉及一种含有胺或二胺的增稠水基组合物，胺或二胺含有至少一个氮连接烃基，该烃基代表饱和或不饱和的直链或支链烷基，至少含有 10 个碳原子，最好是 16-24 个碳原子，或芳基、芳烷基或烷芳基，最多含有 24 个碳原子，其中任选的其他氮连接基团由任选取代的烷基形成、其中胺为杂环形式，含有至少两个氮原子，其中一个氮原子被氨基（低级）烷基或羟基（低级）烷基取代，而环进一步含有线性或支链烷基或烯基，最好与脂肪酸反应，或含有至少 10 个碳原子的烯基； 以酸或盐形式存在的磺酸积甲苯酯、磺酸二甲苯酯、磺酸甲苯酯或它们的混合物；以及 pK 值大于 2.0 的弱酸；以及 水，其中可选择性地溶解或分散一种或多种清洁消毒剂和/或除臭剂。 本发明还涉及由上述胺类和磺酸盐组成的预混组合物，可通过用水或水溶液或悬浮液稀释来制备增稠的水性组合物，还涉及一种用于清洁非水平表面的工艺。
• MODIFIED BLOCK COPOLYMER, METHOD FOR PRODUCING MODIFIED BLOCK COPOLYMER, AND RESIN COMPOSITION
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3623398A1

  公开（公告）日：2020-03-18

  A modified block copolymer according to the present invention is a modified block copolymer comprising a polymer block comprising a vinyl aromatic compound as a main constituent (A), a polymer block comprising a conjugate diene compound as a main constituent (B), and an atomic group having NHx (x = 0 to 2) (C). In the modified block copolymer, the polymer block comprising a conjugate diene compound as a main constituent (B) is a hydrogenated product, the atomic group having NHx (x = 0 to 2) (C) is contained in a side chain, and a compound forming the atomic group having NHx (x = 0 to 2) (C) satisfies the following condition: Condition: when the compound forming the atomic group having NHx (x = 0 to 2) (C) is reacted with a maleic anhydride-modified group in a maleic anhydride-modified block copolymer, a MFR value at 230°C under a load of 2.16 kg of the modified block copolymer after the reaction is 0.1 times or more a MFR value at 230°C under a load of 2.16 kg of the maleic anhydride-modified block copolymer before the reaction.

  根据本发明，改性嵌段共聚物是一种改性嵌段共聚物，包括以乙烯基芳香族化合物为主要成分的聚合物嵌段（A）、以共轭二烯化合物为主要成分的聚合物嵌段（B）和具有 NHx（x = 0 至 2）的原子团（C）。在改性嵌段聚合物中，由共轭二烯化合物作为主要成分（B）的聚合物嵌段是氢化产物，具有 NHx（x = 0 至 2）（C）的原子团包含在侧链中，形成具有 NHx（x = 0 至 2）（C）的原子团的化合物满足以下条件： 条件：当形成具有 NHx（x = 0 至 2）(C)的原子团的化合物与马来酸酐改性嵌段共聚物中的马来酸酐改性基团反应时，反应后在 230℃、负载 2.16 千克改性嵌段共聚物时的 MFR 值是反应前在 230℃、负载 2.16 千克马来酸酐改性嵌段共聚物时的 MFR 值的 0.1 倍或以上。
• Low viscosity lubricating oil compositions for turbomachines
  申请人：ExxonMobil Research and Engineering Company

  公开号：US10689593B2

  公开（公告）日：2020-06-23

  This disclosure relates to a low viscosity lubricating turbine oil having a composition comprising a lubricating oil base stock, as a major component, and one or more lubricating oil additives, as minor components. The lubricating turbine oil has a kinematic viscosity of about 16 cSt to about 22 cSt at 40° C., a density of about 0.8 g/ml to about 0.9 g/ml, and an absolute evaporation loss at 150° C. of less than about 4%. This disclosure also relates to a method for improving energy efficiency in a turbomachine lubricated with the low viscosity lubricating turbine oil. This disclosure further relates to a method for improving energy efficiency while maintaining or improving deposit control and lubricating oil additive solvency in a turbomachine lubricated with the low viscosity lubricating turbine oil. This disclosure yet further relates to a method for improving solubility, compatibility and dispersancy of polar additives in the low viscosity lubricating turbine oil.

  本公开涉及一种低粘度润滑涡轮机油，其成分包括作为主要成分的润滑油基础油和作为次要成分的一种或多种润滑油添加剂。该润滑涡轮机油在 40° C 时的运动粘度约为 16 cSt 至约 22 cSt，密度约为 0.8 g/ml 至约 0.9 g/ml，在 150° C 时的绝对蒸发损失小于约 4%。本公开还涉及一种在使用低粘度润滑涡轮机油润滑的涡轮机械中提高能效的方法。本公开还涉及一种在使用低粘度润滑涡轮机油润滑的涡轮机械中提高能效，同时保持或改善沉积物控制和润滑油添加剂溶解度的方法。本公开还进一步涉及一种改善极性添加剂在低粘度润滑涡轮机油中的溶解性、相容性和分散性的方法。