3-chloro-4-fluoro-N-piperidin-4-ylbenzamide | 869990-66-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chloro-4-fluoro-N-piperidin-4-ylbenzamide
• CAS: 869990-66-9
• 化学式: C₁₂H₁₄ClFN₂O
• mdl: MFCD11849677
• 分子量: 256.707
• InChiKey: DGRKOTOQUSEGKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(bromomethyl)-6-(methoxymethyl)naphthalene 、 3-chloro-4-fluoro-N-piperidin-4-ylbenzamide 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 12.0h， 生成 3-chloro-4-fluoro-N-(1-{[6-(methoxymethyl)-2-naphthyl]methyl}piperidin-4-yl)benzamide
  参考文献：
  名称：

  EP2098509

  摘要：

  公开号：
• 作为产物：
  描述：

  tert-butyl 4-[(3-chloro-4-fluorobenzoyl)amino]piperidine-1-carboxylate 在 盐酸 、 sodium hydroxide 作用下， 以 乙酸乙酯 、 水 为溶剂， 反应 4.0h， 生成 3-chloro-4-fluoro-N-piperidin-4-ylbenzamide
  参考文献：
  名称：

  [EN] 7-PIPERIDINOALKYL-3,4-DIHYDROQUINOLONE DERIVATIVE
  [FR] DÉRIVÉ DE 7-PIPÉRIDINOALKYLE-3,4-DIHYDROQUINOLONE

  摘要：

  为了提供一种新型化合物、药用可接受的盐或其水合物，用于预防或治疗抑郁症、焦虑障碍（如广泛性焦虑障碍、创伤后应激障碍、恐慌障碍、强迫症或社交焦虑障碍）、注意力缺陷障碍、狂躁症、躁郁病、精神分裂症、情绪障碍、压力、睡眠障碍、发作、记忆障碍、认知障碍、痴呆、健忘症、谵妄、肥胖、进食障碍、食欲障碍、暴饮暴食、贪食症、厌食症、糖尿病、心血管疾病、高血压、血脂异常、心肌梗死、运动障碍（如帕金森病、癫痫、抽搐或震颤）、药物滥用、药物成瘾或性功能障碍，基于黑色素浓集素受体（MCH受体）的拮抗作用。解决方案是一种化合物，药用可接受的盐或其水合物，其化学式表示为（I）。

  公开号：

  WO2010038901A1

文献信息

• 1-NAPHTHYL ALKYLPIPERIDINE DERIVATIVE
  申请人：Sekiguchi Yoshinori

  公开号：US20100081825A1

  公开（公告）日：2010-04-01

  Disclosed is a pharmaceutical composition comprising a compound represented by the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient, which has an antagonistic activity on a melanin-concentrating hormone receptor. The pharmaceutical composition is useful, due to its antagonistic activity on a MCH receptor, for the prevention or treatment of a disease such as depression, anxiety disorders (e.g., generalized anxiety disorder, post traumatic stress disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder), attention deficit disorder, mania, manic-depressive disorder, schizophrenia, mood disorders, stress, sleep disorder, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, a cardiovascular diseases, hypertension, dyslipidemia, cardiac infarction, movement disorder (e.g., Parkinson's disease, epilepsy, convulsion, tremor), drug abuse and drug addiction.

  本发明揭示了一种药物组合物，其包括一种由式(I)表示的化合物或其药学上可接受的盐作为活性成分，该化合物具有对黑色素浓集激素受体的拮抗活性。该药物组合物由于其对MCH受体的拮抗活性，可用于预防或治疗抑郁症、焦虑障碍（例如广泛性焦虑症、创伤后应激障碍、恐慌症、强迫症、社交焦虑症）、注意力缺陷障碍、躁狂、躁郁症、精神分裂症、情绪障碍、压力、睡眠障碍、发作、记忆障碍、认知障碍、痴呆、健忘症、谵妄、肥胖症、进食障碍、食欲障碍、过度进食、暴食症、食物恐惧症、糖尿病、心血管疾病、高血压、脂质代谢异常、心肌梗塞、运动障碍（例如帕金森病、癫痫、抽搐、震颤）、药物滥用和药物成瘾等疾病的预防或治疗。
• 7-PIPERIDINOALKYL-3, 4-DIHYDROQUINOLONE DERIVATIVE
  申请人：Kanuma Kosuke

  公开号：US20110178304A1

  公开（公告）日：2011-07-21

  Problem To provide a novel compound, a pharmaceutically acceptable salt or a hydrate thereof useful for preventing or treating for depression, anxiety disorders (such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder or social anxiety disorder), attention deficit disorder, mania, manic-depressive illness, schizophrenia, mood disorders, stress, sleep disorders, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, cardiovascular diseases, hypertension, dyslipidemia, myocardial infarction, movement disorder (such as Parkinson's disease, epilepsy, convulsion or tremor), drug abuse, drug addiction or sexual dysfunction, based on a melanin-concentrating hormone receptor (MCH receptor) antagonistic action. Solution A compound, a pharmaceutically acceptable salt or a hydrate thereof represented by the formula (I).

  问题：提供一种新化合物、药用可接受的盐或其水合物，用于预防或治疗抑郁症、焦虑症（如广泛性焦虑症、创伤后应激障碍、恐慌症、强迫症或社交焦虑症）、注意力缺陷障碍、躁狂、躁郁病、精神分裂症、情绪障碍、压力、睡眠障碍、发作、记忆障碍、认知障碍、痴呆、健忘症、谵妄、肥胖症、进食障碍、食欲障碍、暴食症、食物恐惧症、糖尿病、心血管疾病、高血压、血脂异常、心肌梗塞、运动障碍（如帕金森病、癫痫、惊厥或震颤）、药物滥用、药物成瘾或性功能障碍，基于黑色素浓集激素受体（MCH受体）拮抗作用。 解决方案：一种化合物、药用可接受的盐或其水合物，其化学式为（I）。
• 7-piperidinoalkyl-3, 4-Dihydroquinolone derivative
  申请人：Kanuma Kosuke

  公开号：US08461182B2

  公开（公告）日：2013-06-11

  PROBLEM To provide a novel compound, a pharmaceutically acceptable salt or a hydrate thereof useful for preventing or treating for depression, anxiety disorders (such as generalized anxiety disorder, posttraumatic stress disorder, panic disorder, obsessive-compulsive disorder or social anxiety disorder), attention deficit disorder, mania, manic-depressive illness, schizophrenia, mood disorders, stress, sleep disorders, attacks, memory impairment, cognitive impairment, dementia, amnesia, delirium, obesity, eating disorder, appetite disorder, hyperphagia, bulimia, cibophobia, diabetes, cardiovascular diseases, hypertension, dyslipidemia, myocardial infarction, movement disorder (such as Parkinson's disease, epilepsy, convulsion or tremor), drug abuse, drug addiction or sexual dysfunction, based on a melanin-concentrating hormone receptor (MCH receptor) antagonistic action. SOLUTION A compound, a pharmaceutically acceptable salt or a hydrate thereof represented by the formula (I).

  问题：提供一种新的化合物、其药物可接受的盐或水合物，用于预防或治疗抑郁症、焦虑症（如广泛性焦虑症、创伤后应激障碍、恐慌症、强迫症或社交焦虑症）、注意力缺陷障碍、躁狂症、躁郁病、精神分裂症、情绪障碍、压力、睡眠障碍、发作、记忆障碍、认知障碍、痴呆、健忘症、谵妄、肥胖症、饮食障碍、食欲障碍、暴食症、食物恐惧症、糖尿病、心血管疾病、高血压、血脂异常、心肌梗塞、运动障碍（如帕金森病、癫痫、抽搐或震颤）、药物滥用、药物成瘾或性功能障碍，基于黑色素浓缩激素受体（MCH受体）拮抗作用。 解决方案：化合物、其药物可接受的盐或水合物，由式（I）表示。
• 7-PIPERIDINOALKYL-3,4-DIHYDROQUINOLONE DERIVATIVE
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：EP2344471A1

  公开（公告）日：2011-07-20
• US8461182B2
  申请人：——

  公开号：US8461182B2

  公开（公告）日：2013-06-11