Hexamethylen-dibiguanid | 24447-89-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Hexamethylen-dibiguanid
• 英文别名: Hexamethylene-dibiguanide；1,1'-hexamethylenedibiguanide；2-[6-[[amino-(diaminomethylideneamino)methylidene]amino]hexyl]-1-(diaminomethylidene)guanidine
• CAS: 24447-89-0
• 化学式: C₁₀H₂₄N₁₀
• 分子量: 284.368
• InChiKey: RXGSAYBOEDPICZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  206
• 氢给体数：
  6
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,5-二氯苯胺盐酸盐 、 Hexamethylen-dibiguanid 在 乙二醇乙醚 作用下， 生成 5,5'-bis-(2,5-dichloro-phenyl)-1,1'-hexanediyl-bis-biguanide; dihydrochloride
  参考文献：
  名称：

  850.具有抗菌活性的双双胍

  摘要：

  DOI：

  10.1039/jr9560004422
• 作为产物：
  描述：

  6-氨基-1-己烷氯化铵 、 二聚氰胺 以 xylene 为溶剂， 生成 Hexamethylen-dibiguanid
  参考文献：
  名称：

  Beyer,H.; Lemke,W., Chemische Berichte, 1966, vol. 99, p. 2123 - 2126

  摘要：

  DOI：

文献信息

• Novel Compounds Containing Multiple Guanide Groups That Bind the HIV Coreceptor CXCR4
  作者：Royce A. Wilkinson、Seth H. Pincus、Joyce B. Shepard、Sarah K. Walton、Edward P. Bergin、Mohamed Labib、Martin Teintze

  DOI：10.1128/aac.00709-10

  日期：2011.1

  The G-protein-coupled receptor CXCR4 acts as a coreceptor for human immunodeficiency virus type 1 (HIV-1) infection, as well as being involved in signaling cell migration and proliferation. Compounds that block CXCR4 interactions have potential uses as HIV entry inhibitors to complement drugs such as maraviroc that block the alternate coreceptor CCR5 or in cancer therapy. The peptide T140, which contains five arginine residues, is the most potent antagonist of CXCR4 developed to date. In a search for nonpeptide CXCR4 ligands that could inhibit HIV entry, three series of compounds were synthesized from 12 linear and branched polyamines with 2, 3, 4, 6, or 8 amino groups, which were substituted to produce the corresponding guanidines, biguanides, or phenylguanides. The resulting compounds were tested for their ability to compete with T140 for binding to the human CXCR4 receptor expressed on mammalian cells. The most effective compounds bound CXCR4 with a 50% inhibitory concentration of 200 nM, and all of the compounds had very low cytotoxicity. Two series of compounds were then tested for their ability to inhibit the infection of TZM-bl cells with X4 and R5 strains of HIV-1. Spermine phenylguanide and spermidine phenylguanide inhibited infection by X4 strains, but not by R5 strains, at low micromolar concentrations. These results support further investigation and development of these compounds as HIV entry inhibitors.

  摘要 G 蛋白偶联受体 CXCR4 是人类免疫缺陷病毒 1 型（HIV-1）感染的核心受体，并参与细胞迁移和增殖的信号传递。阻断 CXCR4 相互作用的化合物有可能用作 HIV 进入抑制剂，以补充马拉维若等阻断替代核心受体 CCR5 的药物，或用于癌症治疗。多肽 T140 含有五个精氨酸残基，是迄今为止开发的最有效的 CXCR4 拮抗剂。在寻找可抑制 HIV 进入的非肽 CXCR4 配体的过程中，我们从 12 个含有 2、3、4、6 或 8 个氨基的线性和支链多胺中合成了三个系列的化合物，并将其取代以产生相应的胍类、双胍类或苯基胍类。测试了所得化合物与 T140 竞争结合哺乳动物细胞上表达的人类 CXCR4 受体的能力。最有效的化合物与 CXCR4 结合的 50% 抑制浓度为 200 nM，而且所有化合物的细胞毒性都很低。然后测试了两个系列的化合物抑制 TZM-bl 细胞感染 X4 和 R5 株 HIV-1 的能力。在低微摩尔浓度下，精胺苯胍和亚精胺苯胍能抑制 X4 株的感染，但不能抑制 R5 株的感染。这些结果支持进一步研究和开发这些化合物作为 HIV 进入抑制剂。
• Cleaning formulation for removing residues on surfaces
  申请人：Fujifilm Electronic Materials U.S.A., Inc.

  公开号：US10253282B2

  公开（公告）日：2019-04-09

  This disclosure relates to a cleaning composition that contains 1) at least one redox agent; 2) at least one first chelating agent, the first chelating agent being a polyaminopolycarboxylic acid; 3) at least one second chelating agent different from the first chelating agent, the second chelating agent containing at least two nitrogen-containing groups; 4) at least one metal corrosion inhibitor, the metal corrosion inhibitor being a substituted or unsubstituted benzotriazole; 5) at least one organic solvent selected from the group consisting of water soluble alcohols, water soluble ketones, water soluble esters, and water soluble ethers; 6) water; and 7) optionally, at least one pH adjusting agent, the pH adjusting agent being a base free of a metal ion. This disclosure also relates to a method of using the above composition for cleaning a semiconductor substrate.

  本公开涉及一种清洁组合物，其中包含：1）至少一种氧化还原剂；2）至少一种第一螯合剂，第一螯合剂为聚氨基多羧酸；3）至少一种不同于第一螯合剂的第二螯合剂，第二螯合剂含有至少两个含氮基团；4) 至少一种金属缓蚀剂，该金属缓蚀剂为取代或未取代的苯并三唑； 5) 至少一种有机溶剂，该有机溶剂选自由水溶性醇、水溶性酮、水溶性酯和水溶性醚组成的组； 6) 水；以及 7) 可选地，至少一种 pH 值调节剂，该 pH 值调节剂为不含金属离子的碱。本公开还涉及一种使用上述组合物清洗半导体基底的方法。
• Textile coating composition
  申请人：——

  公开号：US20010046824A1

  公开（公告）日：2001-11-29

  The present invention features novel methods and compositions for coating textile substrates, wherein the coating compositions are composed of a coating agent selected from one of (a) an azetidinium polymer, (b) a guanidine polymer, (c) a mixture of an azetidinium polymer and a guanidine polymer, and (d) a copolymer of an azetidinium monomer and a guanidine monomer. Textile substrates coated with the compositions provide high quality printed images when printed with an ink containing a reactive dye having ionizable and/or nucleophilic groups capable of reacting with the coating agent in the textile coating composition. Images printed on a textile substrate coated with a coating composition of the invention are bleed-resistant, water-resistant (e.g., water-fast), detergent-resistant (e.g., detergent-fast), and/or are characterized by an enhanced chroma and hue.

  本发明的特点是用于涂布纺织基材的新型方法和组合物，其中涂布组合物由选 自以下几种之一的涂布剂组成：(a)氮杂环丁烷聚合物；(b)胍聚合物；(c)氮杂环 丁烷聚合物和胍聚合物的混合物；(d)氮杂环丁烷单体和胍单体的共聚物。当使用含有活性染料的油墨进行印刷时，涂有这些组合物的纺织基材可提供高质量的印刷图像，活性染料具有可电离和/或亲核基团，能与纺织涂层组合物中的涂层剂发生反应。在涂有本发明涂层组合物的纺织品基底上印制的图像具有抗渗性、防水性（如耐水性）、耐洗涤剂性（如耐洗涤剂性），和/或具有增强的色度和色调。
• Composition for textile printing
  申请人：——

  公开号：US20030062506A1

  公开（公告）日：2003-04-03

  The present invention features novel methods and compositions for coating textile substrates, wherein the coating compositions are composed of a coating agent selected from one of (a) an azetidinium polymer, (b) a guanidine polymer, (c) a mixture of an azetidinium polymer and a guanidine polymer, and (d) a copolymer of an azetidinium monomer and a guanidine monomer. Textile substrates coated with the compositions provide high quality printed images when printed with an ink containing a reactive dye having ionizable and/or nucleophilic groups capable of reacting with the coating agent in the textile coating composition. Images printed on a textile substrate coated with a coating composition of the invention are bleed-resistant, water-resistant (e.g., water-fast), detergent-resistant (e.g., detergent-fast), and/or are characterized by an enhanced chroma and hue.

  本发明的特点是用于涂布纺织基材的新型方法和组合物，其中涂布组合物由选 自以下几种之一的涂布剂组成：(a)氮杂环丁烷聚合物；(b)胍聚合物；(c)氮杂环 丁烷聚合物和胍聚合物的混合物；(d)氮杂环丁烷单体和胍单体的共聚物。当使用含有活性染料的油墨进行印刷时，涂有这些组合物的纺织基材可提供高质量的印刷图像，活性染料具有可电离和/或亲核基团，能与纺织涂层组合物中的涂层剂发生反应。在涂有本发明涂层组合物的纺织品基底上印制的图像具有抗渗性、防水性（如耐水性）、耐洗涤剂性（如耐洗涤剂性），和/或具有增强的色度和色调。
• Treatment of substrates to enhance the quality of printed images thereon using azetidinium and/or guanidine polymers
  申请人：——

  公开号：US20030087112A1

  公开（公告）日：2003-05-08

  Compositions and methods are provided for improving the quality of images printed on a substrate. The novel image-enhancing compositions contain as an image-enhancing agent (a) an azetidinium polymer, (b) a guanidine polymer, (c) a mixture of an azetidinium polymer and a guanidine polymer, or (d) a copolymer of an azetidinium monomer and a guanidine monomer. When applied to a substrate, the compositions provide for high quality printed images when the treated substrate is printed on with an ink containing a reactive dye capable of reacting with the image-enhancing agent. Images printed on a substrate treated with the image-enhancing compositions of the invention are water-resistant (e.g., water-fast), bleed-resistant, rub-resistant, and/or are characterized by an enhanced chroma and hue.

  本发明提供了用于提高印在基底上的图像质量的组合物和方法。新型图像增强组合物含有以下图像增强剂：(a) 氮杂环丁烷聚合物，(b) 胍聚合物，(c) 氮杂环丁烷聚合物和胍聚合物的混合物，或 (d) 氮杂环丁烷单体和胍单体的共聚物。将这些组合物涂在基底上，用含有能与图像增强剂反应的活性染料的油墨在处理过的基底上印刷，可获得高质量的印刷图像。用本发明的图像增强组合物处理过的承印物上印刷的图像具有防水性（如防水）、抗渗漏性、抗擦伤性和/或色度和色调增强的特点。