17α-methyl-17β-hydroxy-5ξ-androstan-3-one | 29244-16-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17α-methyl-17β-hydroxy-5ξ-androstan-3-one
• 英文别名: 17α-methyldihydrotestosterone；17β-Hydroxy-17α-methyl-androstan-3-on；mestanolone；(8R,9S,10S,13S,14S,17S)-17-hydroxy-10,13,17-trimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
• CAS: 29244-16-4
• 化学式: C₂₀H₃₂O₂
• 分子量: 304.473
• InChiKey: WYZDXEKUWRCKOB-SRVJTCQVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  17α-methyl-17β-hydroxy-5ξ-androstan-3-one 在 N,N-二乙基(2-氯-1,1,2-三氟乙基)胺 作用下， 以 四氢呋喃 为溶剂， 生成 17,17-Dimethyl-18-nor-androst-13-en-3-on
  参考文献：
  名称：

  Steroids. CCXL.^1,2 The Reaction of Steroidal Alcohols with 2-Chloro-1,1,2-trifluorotriethylamine

  摘要：

  DOI：

  10.1021/jo01031a019

文献信息

• TEMPERATURE DETECTION MATERIAL, TEMPERATURE DETECTION INK USING SAME, TEMPERATURE INDICATOR, AND ARTICLE MANAGEMENT SYSTEM
  申请人：HITACHI INDUSTRIAL EQUIPMENT SYSTEMS CO., LTD.

  公开号：EP3614113A1

  公开（公告）日：2020-02-26

  A temperature detecting material comprises a first material containing a first temperature indicating material (temperature indicating material A) and a second material containing a second temperature indicating material (for example, temperature indicating material B), wherein the first temperature indicating material and the second temperature indicating material contain a leuco dye, a color developing agent, and a decoloring agent, and have a hysteresis characteristic in their color density-temperature curves, wherein the first temperature indicating material has a color developing temperature (Ta1 (Ta1A)) in a temperature increase process lower than a decoloring temperature (Td1 (Td1A)) in the temperature increase process, and turns to a non-crystalline state and is kept in a decoloring state when cooled down below the color developing temperature (Ta1) in the temperature increase process with a predetermined cooling speed or more after melting, wherein the second temperature indicating material, a color developing temperature (Ta2 (Ta2B)) is lower than a decoloring temperature (Td2 (Td2B)) in the temperature increase process, and wherein the color developing temperature (Ta1) in the temperature increase process is lower than the decoloring temperature (Td2) in the temperature increase process and the color developing temperature (Ta2) is lower than the color developing temperature (Ta1) in the temperature increase process.

  一种温度检测材料包括含有第一种温度指示材料（温度指示材料 A）的第一种材料和含有第二种温度指示材料（例如温度指示材料 B）的第二种材料，其中第一种温度指示材料和第二种温度指示材料含有一种白兰地染料、其中第一温度指示材料和第二温度指示材料含有一种白光染料、一种显色剂和一种脱色剂，它们的色密度-温度曲线具有滞后特性，其中第一温度指示材料在升温过程中的显色温度（Ta1 (Ta1A)）低于升温过程中的脱色温度（Td1 (Td1A)）、并在熔化后以预定的冷却速度冷却到升温过程中的显色温度 (Ta1) 以下时变成非结晶状态并保持脱色状态，其中第二温度指示材料的显色温度 (Ta2 (Ta2B)) 低于升温过程中的脱色温度 (Td2 (Td2B))、其中温度升高过程中的显色温度 (Ta1) 低于温度升高过程中的脱色温度 (Td2)，显色温度 (Ta2) 低于温度升高过程中的显色温度 (Ta1)。
• TEMPERATURE DETECTION INK, TEMPERATURE DETECTION INK INITIALIZATION METHOD, TEMPERATURE INDICATOR, AND ARTICLE MANAGEMENT SYSTEM
  申请人：HITACHI INDUSTRIAL EQUIPMENT SYSTEMS CO., LTD.

  公开号：EP3745106A1

  公开（公告）日：2020-12-02

  It is possible to provide a temperature detection ink, which allows color initialization by a simple method and discolors with addition of time and temperature at a reaction temperature or higher. To solve the problem, the temperature detection ink according to the present invention includes a temperature detection material and a solvent. The temperature detection material has a structure in which a thermosensitive material containing a leuco dye, a color-developing agent, and a decolorant is contained in a microcapsule, or a structure in which a phase containing the thermosensitive material is phase-separated from a matrix material. The thermosensitive material is solidified while being decolored by cooling from a molten state to a glass transition temperature or lower at a predetermined rate or higher. The thermosensitive material has a glass transition temperature of -20 to 60°C, and a melting point that is 60 to 250°C and lower than the boiling point of the solvent.

  有可能提供一种温度检测墨水，它可以通过简单的方法初始化颜色，并在反应温度或更高的温度下随着时间和温度的增加而褪色。为了解决这个问题，本发明的温度检测墨水包括温度检测材料和溶剂。温度检测材料的结构是在微胶囊中含有一种热敏材料，其中包含一种白兰地染料、一种显色剂和一种脱色剂，或者是含有热敏材料的相与基体材料相分离的结构。在脱色过程中，热敏材料以预定或更高的速度从熔融状态冷却到玻璃化转变温度或更低的温度，从而固化。热敏材料的玻璃化温度为-20 至 60°C，熔点为 60 至 250°C，低于溶剂的沸点。
• TEMPERATURE DETECTION LABEL AND ARTICLE MANAGEMENT DEVICE USING SAME
  申请人：Hitachi, Ltd.

  公开号：EP3745105A1

  公开（公告）日：2020-12-02

  The present invention addresses the problem of providing a temperature detection label capable of preventing falsification using a simple structure. To solve this problem, the present invention provides a temperature detection label that is characterized by comprising a supporting member and a temperature detection part provided on the supporting member and in that: the temperature detection part has a temperature detection material that, in a heating process, starts color development at temperature T1 and starts losing color as a result of melting at temperature T2 and, in a cooling process, solidifies while remaining colorless by being cooled to temperature T1 or lower; the temperature detection material includes a leuco dye, decolorizer, and developer; and the temperature detection label also comprises a member having an appearance that changes between T1 and T2, inclusive, or a high-melting-point material having a melting point or glass transition temperature higher than T2.

  本发明要解决的问题是提供一种结构简单、能够防止伪造的温度检测标签。为了解决这个问题，本发明提供了一种温度检测标签，其特征在于包括一个支撑部件和一个设置在支撑部件上的温度检测部件，其中，温度检测部件具有温度检测材料：温度检测部件具有温度检测材料，该材料在加热过程中，在温度 T1 开始显色，在温度 T2 熔化而开始失色，在冷却过程中，冷却到温度 T1 或更低温度时，固化而保持无色；温度检测材料包括白兰地染料、脱色剂和显影剂；温度检测标签还包括具有在 T1 和 T2（包括 T1 和 T2）之间外观变化的部件，或熔点或玻璃化转变温度高于 T2 的高熔点材料。
• Resist composition and patterning process using the same
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US10005868B2

  公开（公告）日：2018-06-26

  The present invention provides a resist composition containing a base resin composed of a polymer compound having a repeating unit in which a hydrogen atom of a carboxyl group is substituted with one or more acid-labile groups selected from groups shown by the following general formulae (1-1) to (1-5), wherein R1 to R5 represent a linear, branched, or cyclic alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, or an alkynyl group having 2 to 4 carbon atoms; R6 represents a hydroxyl group or an alkoxy group or acyloxy group having 1 to 6 carbon atoms; and “m” represents 1 or 2. There can be provided a resist composition that can improve the dissolution contrast of a resist film and reduce the film shrinkage after PEB, and a patterning process using the same.

  本发明提供了一种抗蚀剂组合物，该抗蚀剂组合物含有由聚合物化合物组成的基体树脂，该聚合物化合物具有一个重复单元，在该重复单元中，羧基的氢原子被一个或多个酸性基团取代，这些基团选自以下通式（1-1）至（1-5）所示的基团、 其中 R1 至 R5 代表具有 1 至 4 个碳原子的直链、支链或环状烷基、具有 2 至 4 个碳原子的烯基或具有 2 至 4 个碳原子的炔基；R6 代表羟基或具有 1 至 6 个碳原子的烷氧基或酰氧基；"m "代表 1 或 2。本发明可提供一种抗蚀剂组合物，该抗蚀剂组合物可改善抗蚀剂薄膜的溶解对比度并减少 PEB 后的薄膜收缩，还可提供一种使用该抗蚀剂组合物的图案化工艺。
• Systems and methods for rapid evaluation and design of molecules for predicted biological activity
  申请人：——

  公开号：US20040002052A1

  公开（公告）日：2004-01-01

  The computer-based systems and methods are for rapidly evaluating molecules for suspected biological activity and relative potency, and for designing molecules for desired biological activity. The systems and methods enable rapid screening of large molecular databases using one or more search engines designed to identify molecules predicted to possess specific biological activities.

  基于计算机的系统和方法用于快速评估分子的可疑生物活性和相对效力，以及设计具有所需生物活性的分子。这些系统和方法可利用一个或多个搜索引擎快速筛选大型分子数据库，以识别预测具有特定生物活性的分子。