di(5-hydroxy-1-naphthyl)disulfide | 859948-30-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: di(5-hydroxy-1-naphthyl)disulfide
• 英文别名: 5,5'-disulfanediyl-di-[1]naphthol；5.5'-Dioxy-(1.1'-dinaphthyldisulfid)；5,5'-Disulfandiyl-di-[1]naphthol；Bis-(5-oxy-naphthyl-(1))-disulfid
• CAS: 859948-30-4
• 化学式: C₂₀H₁₄O₂S₂
• 分子量: 350.462
• InChiKey: OSRNOTDUOASYCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  40.46
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  di(5-hydroxy-1-naphthyl)disulfide 、 三甲基乙酸酐 生成
  参考文献：
  名称：

  Effects of oxygen–sulfur substitution on glycosaminoglycan-priming naphthoxylosides

  摘要：

  Three series of sulfur-containing analogs to the selectively antiproliferative 2-(6-hydroxynaphthyl) beta-D-xylopyranoside were synthesized and their biological properties investigated. A short, general route to hydroxynaphthyl disulfides from dihydroxy-naphthalenes was developed to utilize the disulfide bond as a sulfur-selective protecting group to enable the orthogonal protection of hydroxyls and thiols. The results indicate that hydrophobic, uncharged oxygen-sulfur substituted naphthoxylosides are taken up by calls and initiate priming of GAG chains to a greater extent compared to the oxygen analogs. No correlation between priming ability and antiproliferative activity was observed. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.05.008
• 作为产物：
  描述：

  5-hydroxy-naphthalene-1-sulfinic acid 在 氢溴酸 作用下， 生成 di(5-hydroxy-1-naphthyl)disulfide
  参考文献：
  名称：

  Rennert, Chemische Berichte, 1915, vol. 48, p. 468

  摘要：

  DOI：

文献信息

• Watson; Dutt, Journal of the Chemical Society, 1922, vol. 121, p. 2415
  作者：Watson、Dutt

  DOI：——

  日期：——