4-methoxy-2,5-dimethyl-phenethyl alcohol | 858855-72-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-methoxy-2,5-dimethyl-phenethyl alcohol
• 英文别名: 5-Methoxy-1.4-dimethyl-2-(β-oxy-aethyl)-benzol；4-Methoxy-2.5-dimethyl-β-phenaethylalkohol；4-Methoxy-2,5-dimethyl-phenaethylalkohol；2-(4-Methoxy-2,5-dimethylphenyl)ethan-1-ol；2-(4-methoxy-2,5-dimethylphenyl)ethanol
• CAS: 858855-72-8
• 化学式: C₁₁H₁₆O₂
• 分子量: 180.247
• InChiKey: AOQWFAPWIFKIEU-UHFFFAOYSA-N

物化性质

• 沸点：
  291.9±35.0 °C(Predicted)
• 密度：
  1.022±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methoxy-2,5-dimethyl-phenethyl alcohol 在 氢溴酸 作用下， 生成 4-(2-bromo-ethyl)-2,5-dimethyl-anisole
  参考文献：
  名称：

  A patient with type I CD36 deficiency whose myocardium accumulated123I-BMIPP after 4 years

  摘要：

  A 73-year-old man with aortic regurgitation was examined by I-123-alpha -methyl-p-iodophenylpentadecanoic acid (BMIPP) myocardial single photon emission computed tomography (SPECT) in 1995. Myocardial accumulation was not evident on either the early or the delayed image obtained 15 minutes and 3 hours, respectively, after injecting I-123-BMIPP. Flow cytometric analysis of CD36 expression in monocytes and platelets identified a type I CD36 deficiency. The patient was hospitalized for severe heart failure in 1999. Upon admission, the cardiothoracic ratio on chest Xrays was 73%, and the left ventricular end-diastolic diameter on echocardiograms was enlarged to 77 mm. On the second day, we performed I-123-BMIPP myocardial SPECT. Myocardial accumulation was evident in the delayed, but not in the early image. We repeated I-123-BMIPP myocardial SPECT on the 10th day after admission. Myocardial accumulation was evident on both early and delayed images. Tc-99m-tetrofosmin myocardial SPECT was immediately performed after I-123-BMIPP myocardial SPECT to distinguish myocardial from pooling images in the left ventricle, but, because the images from both 99mTc-tetrofosmin and I-123-BMIPP myocardial SPECT were idential, we considered that the 123I-BMIPP myocardial SPECT images reflected the actual myocardial condition.The CD36 molecule transports long-chain fatty acid (LCFA) on the myocardial membrane, but I-123-BMIPP scintigraphy does not show any myocardial accumulation in patients with type I CD36 deficiency, indicating that myocardial LCFA uptake occurs through CD36 on the human myocardial membrane. Even though our patient had type I CD36 deficiency, BMIPP was uptaken by the myocardium during heart failure, suggesting a variant pathway on the human myocardial membrane for LCFA uptake.

  DOI：

  10.1007/bf02987845
• 作为产物：
  描述：

  2-(4-methoxy-2,5-dimethylphenyl)ethanamine 在 溶剂黄146 、 sodium nitrite 作用下， 生成 4-methoxy-2,5-dimethyl-phenethyl alcohol
  参考文献：
  名称：

  A patient with type I CD36 deficiency whose myocardium accumulated123I-BMIPP after 4 years

  摘要：

  A 73-year-old man with aortic regurgitation was examined by I-123-alpha -methyl-p-iodophenylpentadecanoic acid (BMIPP) myocardial single photon emission computed tomography (SPECT) in 1995. Myocardial accumulation was not evident on either the early or the delayed image obtained 15 minutes and 3 hours, respectively, after injecting I-123-BMIPP. Flow cytometric analysis of CD36 expression in monocytes and platelets identified a type I CD36 deficiency. The patient was hospitalized for severe heart failure in 1999. Upon admission, the cardiothoracic ratio on chest Xrays was 73%, and the left ventricular end-diastolic diameter on echocardiograms was enlarged to 77 mm. On the second day, we performed I-123-BMIPP myocardial SPECT. Myocardial accumulation was evident in the delayed, but not in the early image. We repeated I-123-BMIPP myocardial SPECT on the 10th day after admission. Myocardial accumulation was evident on both early and delayed images. Tc-99m-tetrofosmin myocardial SPECT was immediately performed after I-123-BMIPP myocardial SPECT to distinguish myocardial from pooling images in the left ventricle, but, because the images from both 99mTc-tetrofosmin and I-123-BMIPP myocardial SPECT were idential, we considered that the 123I-BMIPP myocardial SPECT images reflected the actual myocardial condition.The CD36 molecule transports long-chain fatty acid (LCFA) on the myocardial membrane, but I-123-BMIPP scintigraphy does not show any myocardial accumulation in patients with type I CD36 deficiency, indicating that myocardial LCFA uptake occurs through CD36 on the human myocardial membrane. Even though our patient had type I CD36 deficiency, BMIPP was uptaken by the myocardium during heart failure, suggesting a variant pathway on the human myocardial membrane for LCFA uptake.

  DOI：

  10.1007/bf02987845

文献信息

• SUBSTRAT COMPRENANT UNE SURFACE RECOUVERTE D'UN AGENT ÉPILAME ET PROCÉDÉ D'ÉPILAMAGE D'UN TEL SUBSTRAT
  申请人：The Swatch Group Research and Development Ltd.

  公开号：EP3290451A1

  公开（公告）日：2018-03-07

  L'invention se rapporte à un copolymère et à un substrat comprenant une surface dont au moins une partie est recouverte d'un agent épilame comprenant au moins un composé sous la forme d'un copolymère comprenant des unités V, des unités N, optionnellement au moins une unité M et optionnellement au moins une unité P, associées par liaisons covalentes par leurs chaines principales, où où W, X, Y, Z sont des bras espaceurs, T est un groupement traceur agencé pour déterminer la concentration en agent épilame dans un bain d'épilamage, L est un groupement carboné en C1-C20 halogéné, de préférence fluoré, A constitue un groupement d'ancrage au substrat, Q est H, CH3, ou une chaîne hydrocarbonée différente de T. L'invention concerne également un procédé d'épilamage d'un tel substrat, ledit procédé comprenant une étape de contrôle de la concentration en agent épilame dans le bain d'épilamage au moyen du groupement traceur et si besoin, une étape de réajustement de la concentration en agent épilame dans le bain d'épilamage.

  本发明涉及一种共聚物和一种基底，该基底的表面至少有一部分涂有脱毛剂，该脱毛剂包括至少一种共聚物形式的化合物，该共聚物由 V 单元、N 单元、可选的至少一个 M 单元和可选的至少一个 P 单元组成，它们通过主链以共价键相连，其中 其中 W、X、Y 和 Z 是间隔臂，T 是示踪基团，用于确定脱毛浴中脱毛剂的浓度，L 是卤化的，最好是氟化的 C1-C20 碳基，A 是基底锚定基团，Q 是 H、CH3 或除 T 以外的烃链。 本发明还涉及对这种基底进行脱脂的工艺，所述工艺包括通过示踪基团监测脱脂槽中脱脂剂浓度的步骤，以及必要时重新调整脱脂槽中脱脂剂浓度的步骤。
• A patient with type I CD36 deficiency whose myocardium accumulated123I-BMIPP after 4 years
  作者：Kazuki Ito、Hiroki Sugihara、Takuji Tanabe、Kan Zen、Takatou Hikosaka、Yoshihiko Adachi、Shuji Katoh、Akihiro Azuma、Masao Nakagawa

  DOI：10.1007/bf02987845

  日期：2001.6

  A 73-year-old man with aortic regurgitation was examined by I-123-alpha -methyl-p-iodophenylpentadecanoic acid (BMIPP) myocardial single photon emission computed tomography (SPECT) in 1995. Myocardial accumulation was not evident on either the early or the delayed image obtained 15 minutes and 3 hours, respectively, after injecting I-123-BMIPP. Flow cytometric analysis of CD36 expression in monocytes and platelets identified a type I CD36 deficiency. The patient was hospitalized for severe heart failure in 1999. Upon admission, the cardiothoracic ratio on chest Xrays was 73%, and the left ventricular end-diastolic diameter on echocardiograms was enlarged to 77 mm. On the second day, we performed I-123-BMIPP myocardial SPECT. Myocardial accumulation was evident in the delayed, but not in the early image. We repeated I-123-BMIPP myocardial SPECT on the 10th day after admission. Myocardial accumulation was evident on both early and delayed images. Tc-99m-tetrofosmin myocardial SPECT was immediately performed after I-123-BMIPP myocardial SPECT to distinguish myocardial from pooling images in the left ventricle, but, because the images from both 99mTc-tetrofosmin and I-123-BMIPP myocardial SPECT were idential, we considered that the 123I-BMIPP myocardial SPECT images reflected the actual myocardial condition.The CD36 molecule transports long-chain fatty acid (LCFA) on the myocardial membrane, but I-123-BMIPP scintigraphy does not show any myocardial accumulation in patients with type I CD36 deficiency, indicating that myocardial LCFA uptake occurs through CD36 on the human myocardial membrane. Even though our patient had type I CD36 deficiency, BMIPP was uptaken by the myocardium during heart failure, suggesting a variant pathway on the human myocardial membrane for LCFA uptake.