2-氨基-1,3-二十烷二醇 | 24006-62-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-氨基-1,3-二十烷二醇
• 英文名称: DL-erythro-1,3-Dihydroxy-2-amino-eikosan; DL-erythro-Dihydrosphingosin-C20
• 英文别名: DL-erythro-1,3-Dihydroxy-2-amino-eicosan；Eicosasphinganine；(2S,3R)-2-aminoicosane-1,3-diol
• CAS: 24006-62-0
• 化学式: C₂₀H₄₃NO₂
• 分子量: 329.567
• InChiKey: UFMHYBVQZSPWSS-VQTJNVASSA-N

物化性质

• 沸点：
  471.9±25.0 °C(Predicted)
• 密度：
  0.920±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿:甲醇(5:1)：可溶；乙醇：可溶，温热下溶解

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090
• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  2-氨基-1,3-二十烷二醇 、 十八烷酰氯 在 sodium acetate 、 溶剂黄146 作用下， 生成 DL-erythro-N-Stearoyl-1,3-dihydroxy-2-amino-eikosan
  参考文献：
  名称：

  Zeonkova,E.N. et al., Journal of Organic Chemistry USSR (English Translation), 1968, vol. 4, p. 199 - 201

  摘要：

  DOI：
• 作为产物：
  描述：

  硬脂烷醛 在 镍 氢气 、 potassium carbonate 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 2-氨基-1,3-二十烷二醇
  参考文献：
  名称：

  鞘脂系列研究（十七）：赤型和苏-C 20-二氢鞘氨醇的合成与拆分

  摘要：

  通过向硝基十八醇中添加硝基乙醇，然后还原赤型和苏型硝基二醇，得到了赤型和苏型-1,3-二羟基-2-氨基二十二烷。用1-谷氨酸拆分得到碱的四种旋光形式。d-构型已分配给+-赤型异构体。

  DOI：

  10.1016/0040-4020(61)80099-9

文献信息

• A general, efficient and stereospecific route to sphingosine, sphinganines, phytosphingosines and their analogs
  作者：Ye Cai、Chang-Chun Ling、David R. Bundle

  DOI：10.1039/b516333a

  日期：——

  Sphingosine, sphinganines and phytosphingosines and their analogs were synthesized by an aldol condensation between an iminoglycinate bearing a (+)-(1R,2R,5R)-2-hydroxy-3-pinanone group as chiral auxiliary and an appropriate aldehyde. All condensations proceeded with excellent enantioselectivity to generate the (2S,3R)-D-erythro structures in good yields.

  鞘氨醇，鞘氨醇和植物鞘氨醇及其类似物是通过带有（+）-（1R，2R，5R）-2-羟基-3-吡喃酮基作为手性助剂的亚氨基甘氨酸酸酯与适当的醛之间的醛醇缩合合成的。所有缩合以优异的对映选择性进行，以高收率产生（2S，3R）-D-赤型结构。
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT AND RELATED PRODUCTS THEREOF
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3604269A1

  公开（公告）日：2020-02-05

  The present application relates to extracting, from a traditional Chinese medicine, a plurality of compounds capable of prompting nucleic acid delivery or synthetic compounds, and promoting nucleic acid such as sRNA to absorb and enter a target cell using the extracted compounds or a plurality of combinations and promoting the nucleic acid to enter required target sites in vivo of an object.

  本申请涉及从中药中提取多种能够促使核酸递送的化合物或合成化合物，并利用提取的化合物或多种组合促进核酸（如 sRNA）吸收并进入靶细胞，并促进核酸进入物体体内所需的靶位点。
• APPLICATION OF COMPOUND OR TRADITIONAL CHINESE MEDICINE EXTRACT IN PREPARATION OF NUCLEIC ACID DELIVERY AGENT, AND RELATED PRODUCTS
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3778556A1

  公开（公告）日：2021-02-17

  The present invention relates to extracting multiple types of compounds or synthetic compounds capable of promoting nucleic acid delivery from a traditional Chinese medicine, promoting the absorption of a nucleic acid such as sRNA and the entry thereof into a target cell by using the extracted compounds or multiple combinations, and promoting the entry of the nucleic acid into a target site in an object body having such a need. The traditional Chinese medicine is selected from traditional Chinese medicine decoction pieces derived from Rhodiola rosea, Herba Taraxaci, Herba andrographitis, and Flos Lonicerae. The nucleic acid is used for treating diseases, such as heart, spleen, kidney, stomach, lung and/or bowel diseases.

  本发明涉及从中药中提取能够促进核酸递送的多种化合物或合成化合物，利用提取的化合物或多种组合促进sRNA等核酸的吸收及其进入靶细胞，并促进核酸进入有此需要的物体体内的靶位点。所述中药选自红景天、蒲公英、穿心莲、忍冬藤等中药的煎煮片。核酸用于治疗疾病，如心、脾、肾、胃、肺和/或肠疾病。
• EXTRACTION OF PLANT SOURCE "MEDICINAL SOUP" AND MANUAL PREPARATION OF "HERBAL MEDICINE" AND RELATED PRODUCTS
  申请人：Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

  公开号：EP3789043A1

  公开（公告）日：2021-03-10

  Provided is a preparation method for herbal medicine, comprising the following steps: mixing one or more lipid components and/or with any one or more of the following: nucleic acid, compounds, and macromolecules; and performing heat treatment on the obtained mixture. Also provided is a method for extracting medicinal soup from plants, comprising the following steps: using a solvent to prepare extract solution of a plant; performing differential centrifugation of the extract solution; and using an aqueous solution to re-suspend the precipitate to provide the medicinal soup.

  本发明提供了一种中草药的制备方法，包括以下步骤：将一种或多种脂质成分和/或与以下任一种或多种成分混合：核酸、化合物和大分子；对得到的混合物进行热处理。还提供了一种从植物中提取药汤的方法，包括以下步骤：使用溶剂制备植物提取液；对提取液进行差速离心；以及使用水溶液重新悬浮沉淀，以提供药汤。
• Method for producing acetylated sphingoid base
  申请人：Kao Corporation

  公开号：US10066249B2

  公开（公告）日：2018-09-04

  Provided is a means for producing an acetylated sphingoid base using modified microorganism in the genus Starmerella, particularly Starmerella bombicola. A method for producing an acetylated sphingoid base comprising culturing a microorganism in the genus Starmerella to which a xenogeneic gene encoding a polypeptide having an activity to acetylate a sphingoid base is introduced.

  本发明提供了一种利用改良星菌属微生物，特别是星菌 bombicola 生产乙酰化鞘氨醇碱的方法。生产乙酰化类鞘磷脂碱的方法包括培养星菌属微生物，在该微生物中引入编码具有乙酰化类鞘磷脂碱活性的多肽的异源基因。